Protein Alignment CG11155 and Grin3a

DIOPT Version :10

• Sequence 1: NP_651941.2
• Gene: CG11155 / 43822
• FlyBaseID: FBgn0039927
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: NP_001263284.1
• Gene: Grin3a / 242443
• MGIID: 1933206
• Length: 1135
• Species: Mus musculus
• Alignment Length: 947
• Identity: 213/947 - (22%)
• Similarity: 377/947 - (39%)
• Gaps: 198/947 - (20%)

  Fly    73 KTLLPNTQLVYDIEYVPRDDS---FRTTKKVCSQLEAGV--------QAIFGPTDALLASHVQSI 126
            :||.|...|::.:|.:.|.:.   :..:.:|...:|||:        .:...|..:...|.:||:
Mouse   120 ETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSV 184

  Fly   127 CEAYDI---------PHIEGR-IDLEYNSKEFSINLY-------------PSHTLLTL-----AY 163
            |....:         |..:|. ::|:..|....|.:.             |.|..|:|     :.
Mouse   185 CHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSD 249

  Fly   164 RDIMVYL----NWTKVAIIY-EEDYGL--FNLMHSSTETKAEMYIR---------QASPD--SYR 210
            .|:.|.:    ||...:::. :||:.:  |.|:   ||..::.::.         .::.|  |:.
Mouse   250 ADVTVSILTMNNWYNFSLLLCQEDWNITDFLLL---TENNSKFHLESIINITANLSSTKDLLSFL 311

  Fly   211 QV-LRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVNI 274
            || |..||......::...:...|:..|....|..::....|::..    ::.::|:.|...:.:
Mouse   312 QVQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLHWVLG----DSQNVEELRTEGLPL 372

  Fly   275 TAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHFLNLDNHQN 339
            ............:...:....:|....:.|   :..||.|.||:
Mouse   373 GLIAHGKTTQSVFEYYVQDAMELVARAVAT---ATMIQPELALL--------------------- 413

  Fly   340 FYIKNLSCTSDQTWN--DGISLYNQINAAITDGLTGTVQ-----FVEGRRNIFKLDILKLKQEKI 397
              ...::|...:|.|  .|..|...:......||:|:::     .|....|.|   |..|:.:.:
Mouse   414 --PSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFF---IWNLQYDPM 473

  Fly   398 QK-----VGYWH-----PDDGV----NISDPTAFYDSNIANITLVVMTREERPYVMVKE------ 442
            .|     :|.|.     .|.|:    .....|.|:..|  .:.|.|:|..|.|:|..:|
Mouse   474 GKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPN--KLHLRVVTLIEHPFVFTREVDDEGL 536

  Fly   443 --------------------------DKNLTGNLRFE----GFCIDLLKAIATQVGFQYKIELVP 477
                                      ..|.|..::|:    |:|||||:.:|..:.|.:.:.:|.
Mouse   537 CPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVG 601

  Fly   478 DNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVIDFTKPFMNLGIGILFKV-PTSQ 541
            |..||.:  :...|.|:|.:|:...|::||.|.:||.||..|||||.||.:..:|||.:. .|:.
Mouse   602 DGKYGAW--KNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAA 664

  Fly   542 PTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPHPCYKETDIVENQFSISNSFW 606
            |  :.:||.||...:||.:..|..:.:..|.:      ||||:|.....:.......||.|::..
Mouse   665 P--IGAFMWPLHWTMWLGIFVALHITAIFLTL------YEWKSPFGMTPKGRNRNKVFSFSSALN 721

  Fly   607 FITGTFLRQGSGLN-PKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASD--LA 668
            ........:.:.:. ||..:.|.:...|..||:..:|:|||||||.:..|::...:....|  |.
Mouse   722 VCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLH 786

  Fly   669 EQTE-ISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGI---KRVMEGSYAFL 729
            ..:: ..:||:...|...:.|.|...:::.|.||.        |....||:   |...|...||:
Mouse   787 HPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYN--------VPATPDGVQYLKNDPEKLDAFI 843

  Fly   730 MESTMLDY--AVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWW 792
            |:..:|||  ::..||.|..:|.....:||||..|..||....||..|.:.:..|.:.:|:|||:
Mouse   844 MDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWY 908

  Fly   793 KNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSRKNLNTENQSLCS 857
            |..  .|.:...: .::...:|:::..|:||:|..|..|:::..|.|         :...:.|..
Mouse   909 KVV--PCGKRSFA-VTETLQMGIKHFSGLFVLLCIGFGLSILTTIGE---------HIVYRLLLP 961

  Fly   858 EMAEELRFAMHCHGSKSRHRPRKRSCLNCSSVPTYVP 894
            .:..:.:.....|.|:..||     .||.|.|....|
Mouse   962 RIKNKSKLQYWLHTSQRFHR-----ALNTSFVEEKQP 993

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..413	CDD:380605	72/418 (17%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	117/414 (28%)
		Lig_chan	554..828	CDD:459656	74/282 (26%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600	72/411 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..118
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	116/413 (28%)
		Lig_chan	674..941	CDD:459656	74/283 (26%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987		8/49 (16%)
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1082..1115