DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and glr-6

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_741822.2	Gene:	glr-6 / 180955	WormBaseID:	WBGene00001617	Length:	844	Species:	Caenorhabditis elegans

Alignment Length:	894	Identity:	257/894 - (28%)
Similarity:	419/894 - (46%)	Gaps:	117/894 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 YIILSIL--VISNALPPVIRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYVP 89
            :::||.|  .:|:     ||:|.| |....|.|:.:|....:.|||::.........:....::.
Worm     7 FLLLSFLGTGVSS-----IRIGLI-TSHHLEHSVRTAVNIIVPRINEQIVKTRGACFITHTSFIA 65

  Fly    90 RDDSFR-TTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYNSK-EFSINL 152
            ..:|.. ...|:|....:.|..|.|..|....|.::..|...:|..|.......|..| :.|:||
Worm    66 LKNSHEDLNTKICDLANSEVSVIIGVVDRESGSIIEEQCAELNILFIHYYWTPGYQKKQQTSLNL 130

  Fly   153 YPSHTLLTLAYRDIMVYL----NWTKVAIIYEEDYGLFNLMHSSTETKAEMYIRQASP------- 206
            |||     :.|..:|..|    .|.....||..    ::......||.:.:   :.||
Worm   131 YPS-----MEYSQLMERLINLWRWDNFVYIYSN----YDAPKQLIETLSRL---EKSPALLRAHT 183

  Fly   207 --DSYRQVLRAIRQ--------KEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLET 261
              ||......|:|.        .:..:::::.:|:...:||.:.|:|.|......::.|..|...
Worm   184 LDDSMMATALALRDTCDRNRCWPKKNRVLIELSPNETLTFFDASLKLGMISVHNWFLITALDDLN 248

  Fly   262 YDLEDFRYNSVNITAFRLVDVDSKRYLEVINQ------MQKLQHNGLDTINGSPYIQ-TESALMF 319
            ..|..:.:|.:.::   |:.|..:::    ||      :..:....|..|..:|... .:.|.:|
Worm   249 DHLSQYTHNGMRVS---LLTVSKEKW----NQNDLAIKLPDMYQEYLAKIPSNPRTPFKDFAFIF 306

  Fly   320 DSVYAFANGLHFLNLDNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQF------V 378
            ||:....           |....:.:||..    |:.:..:.........||||.:.|      .
Worm   307 DSILLAC-----------QAGDRRIISCGD----NEAVKKFKLPIVKPFKGLTGKISFNGTSDRS 356

  Fly   379 EGRRNIFKLDILKLKQEKIQKVGYWHPD-DG--------VNISDPTAFYDSNI-ANITLVVMTRE 433
            :...:|:::.|......    .|.|... :|        .||......|.::: .:.||.|.:..
Worm   357 DSELHIWEMGITGAGLH----TGIWKSTWEGSKELTMLAKNIPGTHEHYQASVRESRTLKVTSIH 417

  Fly   434 ERPYVMVKEDKNLTGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQEL 498
            |:|||:.|...:  |.::.||||:|||..:|..:.|.|.:::|.||.||.....|:.|:|::.|:
Worm   418 EKPYVIEKIMPD--GRIKHEGFCVDLLDKLAEMLHFNYTLKIVKDNKYGERKNGTDEWDGMIGEI 480

  Fly   499 MERRADLAVASMTINYARESVIDFTKPFMNLGIGILFKVPT-SQPTRLFSFMNPLAIEIWLYVLA 562
            :...||:|||.:|:...|..|||||.||:.|||.:|.:.|. ...:.|..|:.||:..:|.:...
Worm   481 LRGDADMAVAPITVTATRLEVIDFTDPFLQLGISMLMRQPNPKSSSSLTRFLWPLSASVWTFSAI 545

  Fly   563 AYILVSFALFVMARFSPYEWKNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTR 627
            |.::.:..:.|.|..||          ||:..   :|.|.||.|::....||.|||.|.:|.:||
Worm   546 ATVITALLVTVAAVLSP----------KESTA---EFKIQNSVWYLVCILLRAGSGYNCQAGATR 597

  Fly   628 IVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKI 692
            ::...|:.|.|::|:.||||.||.|||:|...|..|..:|..|||.::|::.|||||.||:.|:|
Worm   598 LISAVWWSFTLVLIAQYTANFAALLTVDRKSMPFNSFEELGNQTEYNFGSILGGSTMQFFKYSRI 662

  Fly   693 GIYQKMWRYMENRKTAVFVKTYEDGIKRVMEGSYAFLMESTMLDYAVQRDCNLTQIGG-LLDSKG 756
            ..::::|..|::.:.:.||.|..:|:.||:...|.|||||..|||.|.::||||::|. :|.|.|
Worm   663 ETFRRLWERMQSAEPSAFVGTNHEGVNRVLNEKYVFLMESATLDYQVTQNCNLTRVGNVVLGSNG 727

  Fly   757 YGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGV 821
            |.||.||||.||:|::..||:|.|||||.:|.:.|||.:...|...:  .|....|||.||:.|:
Worm   728 YSIALPKGSKWREKLTRQILDLNEKGIILMLKNNWWKKSQQECQSSE--PEDLQTALGAENVYGL 790

  Fly   822 FVVLLCGLALAVVVAIFE------FCWNSRKNLNTENQSLCSEMAEELR 864
            |::|..|..:.|:.|:.|      |..|.|.....:.|.:...:..|:|
Worm   791 FLLLALGSGIGVLCAVLEHTHFIFFEKNKRNGQTPKLQQMIETIHAEIR 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	78/410 (19%)
		ANF_receptor	61..393	CDD:279440	69/367 (19%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	149/370 (40%)
		Lig_chan	555..829	CDD:278489	110/274 (40%)
glr-6	NP_741822.2	PBP1_iGluR_non_NMDA-like	21..394	CDD:380591	78/411 (19%)
glr-6	NP_741822.2	PBP2_iGluR_Kainate	409..764	CDD:270432	149/369 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920