DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and glr-8

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_001368711.1	Gene:	glr-8 / 180924	WormBaseID:	WBGene00001619	Length:	547	Species:	Caenorhabditis elegans

Alignment Length:	518	Identity:	124/518 - (23%)
Similarity:	212/518 - (40%)	Gaps:	87/518 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 DILKLKQEKIQKVGYWHP---------DDGVNISDPTAFYDSNIANITL-VVMTREERPYV--MV 440
            :||:...||:.     ||         .|...:|:...|..|.:...|| :|:...|.|||  :.
Worm    21 NILESINEKVA-----HPPQTSLTSDYGDAYTLSNEKHFSLSEMKGRTLKMVVPAIEPPYVNYVN 80

  Fly   441 KEDKNLTGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADL 505
            ..|..:|......|..:::||.|..::...|:|.....:.:|.|:  ..||.|...:|:....||
Worm    81 FSDAAVTDKGYGPGVVMEILKEIGKRLNLTYEILPALGSTWGEYL--NGSWTGAFGQLVRGEVDL 143

  Fly   506 AVASMTINYARESVIDFTKPFMNLGIGILFKVPTS-QPTRLFSFMNPLAIEIWLYVLAAYILVSF 569
            ......:.|.|..:.|.|.||.....||:.:.|.. :...|.....|.:.|:|: :.||.||:|.
Worm   144 LAGGAIMEYDRSVIADLTYPFQFEPTGIMIRSPEKYEDDTLLIVTEPFSWEVWV-ITAAVILISG 207

  Fly   570 ALFVMARFSPYEWKNPHPCYKETDIVE---NQFSIS--NSFWFITGTFLRQGSGLNPKATSTRIV 629
            .:|::.                |:|:.   .:.:::  .|.|.....|::||....|::.|.|::
Worm   208 VIFLVM----------------TNIIRKVYEEMTVTPFESIWVFFSIFVQQGLPEQPRSWSCRVL 256

  Fly   630 GGCWFFFCLIIISSYTANLAAFLTVERMISPIESASD---LAEQTEISYGTLEGGSTMT-FFRDS 690
            ...|:...:.:.:::|.:|.|...|::...|.::...   |.:|.:......|...|.| ....|
Worm   257 VALWWLASITLSATFTGSLVALFAVDKTNVPFQNIDQLVRLVKQGKFEIVMDENSFTRTEMIARS 321

  Fly   691 KIGIYQKMWRYM-ENRKTAVFVKTYEDGIKRVM-----EGSYAFLMESTMLDYAVQRDCNLTQIG 749
            |:.:|:.:|..| .|.|    || |.:||.|.:     ...||.|.....|::....||.:
Worm   322 KLPVYRDLWHEMIVNHK----VK-YVNGIARGVAFVRANPGYALLGPMATLNFYAYSDCKV---- 377

  Fly   750 GLLDSKG-----YGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESK 809
             :|.:.|     ..|...|.|.:....|..|.|:.|:|..|    ||   ..|..:.....|.::
Worm   378 -ILFNDGILPVYLSIPLVKNSIYSPYFSTKIREMVERGFTQ----KW---IADYRSYVAMQKINE 434

  Fly   810 ANA--------LGVENIGGVFVVLL--CGLALAVVVA--IFEFCWNSRKNLNTENQSLCSEMA 860
            .|:        |.::...|.|.|.|  .||.||:.|.  ||:| :..:...:|:..::..|:|
Worm   435 CNSTTIGPKSYLDLKRAQGAFWVFLGGAGLGLALFVGEFIFKF-FREKMTKHTKTTTVPPEVA 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	7/30 (23%)
		ANF_receptor	61..393	CDD:279440	2/4 (50%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	95/392 (24%)
		Lig_chan	555..829	CDD:278489	69/303 (23%)
glr-8	NP_001368711.1	PBP2_iGluR_ligand_binding	62..424	CDD:270219	96/397 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6092
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.760