DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and glr-7

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_001337310.1	Gene:	glr-7 / 180547	WormBaseID:	WBGene00001618	Length:	885	Species:	Caenorhabditis elegans

Alignment Length:	945	Identity:	267/945 - (28%)
Similarity:	417/945 - (44%)	Gaps:	187/945 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KYAIYRINKEKTLLPNTQLVYDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSIC 127
            ||.:..|:.|:         ||.     :|| .....:|.|:             :..|.|.|:|
Worm     6 KYRVDVISLER---------YDF-----NDS-SDINSLCDQM-------------VNVSFVISVC 42

  Fly   128 EAYD-------------IPHIEGRIDLEYNSKEFSIN-------LYPSHT---LLTLAYR----D 165
            .:.|             :|.|:  :||.|.|...:.|       ..||:|   |.||.::    |
Worm    43 RSNDSISLVAELARISQVPTIQ--VDLNYWSLPLNFNGTSVPTISSPSYTTMVLSTLVFQNVITD 105

  Fly   166 IMVYLNWT-KVAIIYEEDY--------GLFNLMHSSTETKAEMYIRQASPDSYRQVLRAIRQKEI 221
            |...||.| ...::|:..|        ..|:::........|..:.:     .|..:..:|...|
Worm   106 IFADLNITPNSTVLYDNMYPPDFTAWRDAFSVLPGIRFVPMETTVLR-----MRAQITQLRMASI 165

  Fly   222 YKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVNITAF--------- 277
            ..:|:.....:::.|     .|:..|.....:|.|:.| |.|:..|:.:|.. :||
Worm   166 NSLILVAKTENVERF-----TLEAADFIEQRVFNTYVL-TKDITAFKCDSCE-SAFMFWLRPFPV 223

  Fly   278 ----RLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHFLN--LDN 336
                .:.|:|...:...|........||.|::|.:.|:....       |||.. :..:|  .|.
Worm   224 GKLMEIRDLDDYLFRNEIGLELDYSINGWDSLNVAFYMNVMG-------YAFET-IRTMNATFDV 280

  Fly   337 HQNFYIK------NLSCT-SDQTWNDGISLYNQINAAITDGLTGTVQFVEGRRNIFKLDILKLKQ 394
            ...|..:      |::.| .|...||....|.....|   ||....|.||.|  |:|:|..:..:
Worm   281 LPTFTCQTGPSEPNITTTVRDIILNDPAHEYGNYTEA---GLNMFFQDVEVR--IYKIDRDRDHE 340

  Fly   395 EKI--QKVGYWHPDDGVNISDPTAFYDSNIANITLVVMTREERPYVMVKEDKNLTGNLRFEGFCI 457
            :.:  ::||.|.|...:::...|...|....||..|| |..:.|:|....|.:..    :||:||
Worm   341 DALFNKEVGVWSPISKLSVMYGTLQVDVRNLNIFRVV-TLIQPPFVQRTGDPDTP----YEGYCI 400

  Fly   458 DLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVIDF 522
            ||:..|..:|.|.|.|..|.|..:|. :.:..:|||::..|:...||:|:|.:::...||:.:||
Worm   401 DLINMIQVEVNFTYTIYEVEDGSFGT-MDDNGNWNGLIGALVSGSADIALAPLSVMAERENDVDF 464

  Fly   523 TKPFMNL-GIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPH 586
            |.|:.:| |..||.|....:.: ||.||..|...:||.::|||:..|..|::..|||||.:.|..
Worm   465 TVPYYDLVGTTILMKKADVEYS-LFKFMKVLEWPVWLCIVAAYLFTSILLWIFDRFSPYSFTNNK 528

  Fly   587 PCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAF 651
            ..| :.||.:.|||:....||...:...||.|..||..|.|:|...|:.|..|||:|||||||||
Worm   529 ERY-QNDIEKRQFSLKECLWFCMTSLTPQGGGEAPKNISGRLVAATWWLFGFIIIASYTANLAAF 592

  Fly   652 LTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFR--------------------------DS 690
            |||.|:..||.|..|||:|.:|.|..::|.::.|:||                          .:
Worm   593 LTVSRLEQPISSLDDLAKQYKIEYAPIKGSASETYFRRMAEIEETFYNMWKEMSLNESMSPRDRA 657

  Fly   691 KIGI--------YQKMWRYMENRKTAVFVKTYEDGIKRVMEGSYAFLMESTMLDYAVQRDCNLTQ 747
            |:.:        :..|||||:..|..|.:.|..|.:...::| :||:.::|.:.||...:|||.|
Worm   658 KLAVWDYPVSDKFTNMWRYMQESKLPVNMDTAVDRVLNSVDG-FAFIGDATEIKYAALTNCNLQQ 721

  Fly   748 IGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANA 812
            :|.....|.|.||...|...:||||.|||.|..:..::.|.:|||.:..:..:..|.|.||  :.
Worm   722 VGTEFSRKPYAIAVQSGHILKDKISSAILMLLNERRLETLKEKWWTDNPNKVSCPDSSDES--DG 784

  Fly   813 LGVENIGGVFVVLLCGLALAVVVAIFEFCW---NSRKNLNTENQSLCSEMAEELRF---AMHCHG 871
            :.::||||||:|:|.|:||::|...||:.:   .:||....|.:.|  ||.:..:.   ..|.:|
Worm   785 ISIQNIGGVFIVILAGIALSIVTLAFEYYYYKRKARKAAEKEQEEL--EMKQSQQVVPNGFHTNG 847

  Fly   872 SK--------------SRHRPRKRSCLNCSSVPTY 892
            .|              :..|..|||    :||..|
Worm   848 VKQDAPKLTNGTKTNGNTFRRTKRS----NSVSAY 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	87/406 (21%)
		ANF_receptor	61..393	CDD:279440	83/387 (21%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	143/403 (35%)
		Lig_chan	555..829	CDD:278489	110/307 (36%)
glr-7	NP_001337310.1	Periplasmic_Binding_Protein_Type_1	<102..>220	CDD:324556	25/129 (19%)
glr-7	NP_001337310.1	PBP2_iGluR_putative	373..767	CDD:270435	142/402 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6092
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.760