DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and glr-5

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_505244.1	Gene:	glr-5 / 179251	WormBaseID:	WBGene00001616	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	934	Identity:	318/934 - (34%)
Similarity:	497/934 - (53%)	Gaps:	78/934 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SYI--ILSILVISNALPPVIRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYV 88
            :||  |.:||.:.:......::||||.|.| ::.||:|.:|::..:: ::.:..:..||  |||:
Worm     6 NYIFSIFTILHVFSTSCIAYKIGAIFRERE-DAHIEAAVRYSVEWLS-QRGIYGDIDLV--IEYI 66

  Fly    89 PRDDSFRTTKKVCSQLEAG-VQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYNSKEFSINL 152
            ...|.:...||.|..||.. :.|:.|.:.|.|.:.::.|.:..|||.:....||..:..:..|:.
Worm    67 DVLDHYDAIKKACKMLEKDHIVALLGGSHAALNAQLERITDDLDIPFLTAIDDLRTDMGKSKIDF 131

  Fly   153 YPSHTLLTLAYRDIMVYLNWTKVAIIYEED---YGLFNLMHSSTETKAEMYIRQASPDSYRQVLR 214
            :|...|.. |..|:..:..|.::.::||.|   ..|..|:.|........|:.:.....|.:..|
Worm   132 WPRPQLFE-AVVDMFTHWRWNRIVLVYEGDERIRRLEQLLESEEYASIRFYLIKVHDGDYMKAAR 195

  Fly   215 AIRQ------------KEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDF 267
            .:::            .|..:::||.||.|..:|..:.||:.:.:.::.::.|..:|.|.|:|.|
Worm   196 QVKELEECRLLHKKDCSEFSRLLVDMNPEHTYTFLLASLQMGLIELKHWFLLTNMELSTMDMELF 260

  Fly   268 RYNSVN-ITAFRLVDVDSKRYLE---VINQMQKLQHN----GLDTINGSPYIQTESALMFDSVYA 324
            |||... |:.:   .|||....|   ..|.....:|.    .:.|.|.......|:...||:|||
Worm   261 RYNHARFISPY---PVDSTFLTENRDAFNFSHFKEHITEKWAMKTDNSRNLKMMEAVFTFDAVYA 322

  Fly   325 FANGLHFLNLDNHQNFYIKNL---SCTSDQTWNDGISLYNQINAAITDGLTGTVQFVEGR--RNI 384
            |||..:.|:.....|...:.|   |..:.:.:..|.||.:.|......||:|.::.:.|.  ::.
Worm   323 FANVFNELSSHMQMNDVPQTLCRKSSRNSRKYQHGRSLIDNIVHNDLHGLSGDLRRLNGHPLKSN 387

  Fly   385 FKLDILKLKQE-KIQKVGYWHPDDGVNIS---DPTAFYDSNIA---------NITLVVMTREERP 436
            |.:.|..|... ::..:|:|.|...|:::   |..|....|:.         .:|.::    |||
Worm   388 FSMRIQLLGYSGRLDDIGFWEPATNVHVNMSGDSKAQLQRNVQVSDELKPHFRVTTIM----ERP 448

  Fly   437 YVMVKEDK-NLTGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELME 500
            |||:|::. .|..|.:|||||||||..::..:||.|.|..|.|..||.......||:|::.|::.
Worm   449 YVMLKKNHYELDANSKFEGFCIDLLAELSKDLGFTYTIHAVKDGKYGNDKYGNGSWDGMMGEILR 513

  Fly   501 RRADLAVASMTINYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYI 565
            ..|::|||.:|:||.|...:||||||::|||.||:|||..|...||||:|||:.:||..:..:.|
Worm   514 GEAEMAVAPLTVNYRRSEAVDFTKPFLSLGISILYKVPDDQQPDLFSFLNPLSWQIWTAIATSII 578

  Fly   566 LVSFALFVMARFSPYEWK---------NPHPC-----YKETDIV-ENQFSISNSFWFITGTFLRQ 615
            .|:..::.:|..:||||.         .|||.     .:|..|| .|.:|..|:.|::..|.|:.
Worm   579 TVTLGMYFVANVTPYEWNLNFSCCTAHEPHPAAAFATNQEAPIVMSNNYSFWNTVWYVLSTMLKG 643

  Fly   616 GSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEG 680
            |....|:|.|||::||.|:.|.|:|||:|||||||.|||.|...||::..|||.||.|||||:.|
Worm   644 GCDFGPRAVSTRLLGGTWWVFYLVIISAYTANLAAVLTVSRPYIPIKNLDDLANQTTISYGTIRG 708

  Fly   681 GSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKRVMEGSYAFLMESTMLDYAVQRDCNL 745
            ||||.||::|:|..:.|||:||:::.  |||.:...|::|.:..:||:|||||.|:|..|::|||
Worm   709 GSTMQFFQESRIAAHVKMWQYMKDKD--VFVTSNGKGVERALSMNYAYLMESTSLEYETQQNCNL 771

  Fly   746 TQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKA 810
            |||||:|.|||||||..|.|.|.|:||..||...::|||::...|||::.|..|.....:.:...
Worm   772 TQIGGVLGSKGYGIALAKKSEWTDRISRQILLYAKRGIIEMKKTKWWRSKGAACASTASAVKHDR 836

  Fly   811 NALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSRKNLNTENQSLCSEMAEELRFAMHCHGSKSR 875
            .||.:.|:.|:|:.|..|:.||.:|.|||...........|.:....|:..|||||::.: |.|.
Worm   837 FALSMYNVAGLFITLGVGIVLAAIVVIFELIHRCHHIAKKEGKPFLEELLYELRFALNMN-SLSD 900

  Fly   876 HRPRKR--SC-LNCSSVPTYVPSN 896
            ||.|::  :| .|.:..|.::..|
Worm   901 HRSRQKMSTCNSNGNGKPNHLNEN 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	100/395 (25%)
		ANF_receptor	61..393	CDD:279440	88/360 (24%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	177/384 (46%)
		Lig_chan	555..829	CDD:278489	125/288 (43%)
glr-5	NP_505244.1	PBP1_iGluR_delta_like	26..418	CDD:107376	101/399 (25%)
		ANF_receptor	38..377	CDD:279440	87/345 (25%)
		PBP2_iGluR_Kainate	438..819	CDD:270432	177/386 (46%)
		Lig_chan	568..855	CDD:278489	125/288 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I4290
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68992
Inparanoid	1	1.050	495	1.000	Inparanoid score	I765
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm14234
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770