Protein Alignment CG11155 and glr-2

DIOPT Version :10

• Sequence 1: NP_651941.2
• Gene: CG11155 / 43822
• FlyBaseID: FBgn0039927
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: NP_001021114.1
• Gene: glr-2 / 175999
• WormBaseID: WBGene00001613
• Length: 977
• Species: Caenorhabditis elegans
• Alignment Length: 903
• Identity: 274/903 - (30%)
• Similarity: 439/903 - (48%)
• Gaps: 144/903 - (15%)

  Fly   100 VCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIE---------GRIDLEYNSKEFSINLYPS 155
            :|.:::.|...:...|:.......:.|.....:|.|:         |: ..|.|...||:  .||
 Worm    86 ICDEMKLGYMLMLAGTNFKNYGIYEDIANHMKMPLIDWEPSKSENIGK-TTENNPMIFSV--APS 147

  Fly   156 HTLLTLAYRDIMVYLNWTKVAIIYEEDYG------LFNLMHSST---ETKAEMYIRQASPDSYRQ 211
            ...|.:   |.:.|..|..|..|::....      :|:.:|..:   :...:.|:..:..:.:::
 Worm   148 AEQLLI---DYIQYKGWRDVVYIHDGKNADRTLRTMFSYLHEKSPKYQLFVDNYVAPSDEEMFKE 209

  Fly   212 VLRAIRQK--------------EI-----YKIIVDTNPSH-IKSFFRSILQLQMNDHRYHYMFTT 256
            .|....::              ||     ..:|||...|: .::|.|::.:..:....|||:|:.
 Worm   210 FLNEFHRRISTQHTLKSNDSSEEIDEPIPVNVIVDLEGSYRTRAFLRALEESVLVKKEYHYVFSN 274

  Fly   257 FDLETYDLEDFRYNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDS 321
            ||::..||..|.::.:|||.||:.|.::|::|:...:...:...|....:..|   |.:|...|:
 Worm   275 FDVDETDLSGFHFSLINITIFRIFDKNNKKFLKTRAEFHDVYRGGFSNTDSIP---TAAAFAHDA 336

  Fly   322 VYA-----------FANGLHFLNLDNHQNFY--IKNLSCT--SDQ-------TWNDGISLYNQIN 364
            :..           ...|:...:...||.|.  .|.|.|.  .||       |:..|..:...|.
 Worm   337 ILVAGKALQIAMNEHGKGIFDKSFVRHQLFNRGRKGLYCRPHEDQTESRQFETFEHGKKIAEAIK 401

  Fly   365 AAI---TDG-LTGTVQF--VEGRRNIFKLDILKLKQ---------EKIQKVGYWHPDDGVNISD- 413
            ..:   .|| |||.:||  |.|:|..|..:|:::|.         |:.|    |...:|..:..
 Worm   402 KVVLTDKDGTLTGRIQFDKVTGKRTNFSAEIVEIKPGVNSLNSIWERFQ----WAEGEGFLLGGE 462

  Fly   414 ------------------PTAFYDSNIANITLVVMTREERPYVMVKE----DKNLTGNLRFEGFC 456
                              |:..:......:|::|     :|:||:|.    :..|.||.||||:|
 Worm   463 RYVQEKKKDSSQTRKGILPSKPWQLRFNVVTVLV-----KPFVMLKRRNPGEPELKGNDRFEGYC 522

  Fly   457 IDLLKAIATQV-GFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVI 520
            ||||..:|..: ||:|.:.:...|.||....: .||:|::..|:...||:|||.:||...||..:
 Worm   523 IDLLNLLAKNITGFEYDVFISDGNKYGSRQAD-GSWDGMIGYLLNETADVAVAPLTITQERERAV 586

  Fly   521 DFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNP 585
            ||:||||..||.|:.|.|..|...:||||.||.:.||::.|::|..||..:|:::.|||||.:..
 Worm   587 DFSKPFMTTGISIMIKKPEKQEFNIFSFMEPLGMTIWIFTLSSYFGVSLTIFLVSWFSPYEKRIE 651

  Fly   586 HPCYKETDI-VENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLA 649
               :|..:. |.|:|::.||.||....|::||:.:.|:|.|.||...||:||.|||:||||||||
 Worm   652 ---FKRGEFTVTNEFTLYNSLWFTLAAFMQQGTDILPRAVSGRIASSCWWFFTLIIVSSYTANLA 713

  Fly   650 AFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYM------------ 702
            ||||:|||..||||..|||.|.:|.||..|||||..||.||.:.:|:|||.:|
 Worm   714 AFLTLERMTPPIESVEDLANQNKILYGVNEGGSTAAFFEDSIVPLYKKMWNFMVSTTQKQIELEK 778

  Fly   703 ----ENRKTAVFVKTYEDGIKRV--MEGSYAFLMESTMLDY-AVQRDCNLTQIGGLLDSKGYGIA 760
                .:....:||.:|.|||::|  .:|.||||:|.|..:| :.:|.|:..::|..|::.|||||
 Worm   779 QSITNSTSNRIFVSSYADGIEKVRTSKGKYAFLLEETTNNYESGRRPCDTMKVGQNLNTLGYGIA 843

  Fly   761 TPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVL 825
            |..|:|.|..::||||.|.|||.::.|.:|||.:.|. |: ...|....:::|.:..:.|:|.:|
 Worm   844 TKIGNPLRVSLNLAILYLSEKGELKKLENKWWYDRGQ-CD-TGTSDGGTSSSLNLSKVAGIFYIL 906

  Fly   826 LCGLALAVVVAIFEFCWNSRK-NLNTENQSLCSEMAEELRFAMHCHGSKSRHRPRKRS 882
            |.|:.|::..|:.||.:...| |...|...:.|....:......|..:|.:....:|:
 Worm   907 LAGMVLSMCTALVEFLFRKNKENREKERNRMRSSRPLKPGILASCERAKQKQLQNRRT 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..413	CDD:380605	82/387 (21%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	170/393 (43%)
		Lig_chan	554..828	CDD:459656	123/293 (42%)
glr-2	NP_001021114.1	PBP1_iGluR_AMPA	24..460	CDD:380603	82/386 (21%)
		Periplasmic_Binding_Protein_Type_2	491..875	CDD:473866	169/392 (43%)