DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and glr-2

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_001021114.1	Gene:	glr-2 / 175999	WormBaseID:	WBGene00001613	Length:	977	Species:	Caenorhabditis elegans

Alignment Length:	903	Identity:	274/903 - (30%)
Similarity:	439/903 - (48%)	Gaps:	144/903 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 VCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIE---------GRIDLEYNSKEFSINLYPS 155
            :|.:::.|...:...|:.......:.|.....:|.|:         |: ..|.|...||:  .||
Worm    86 ICDEMKLGYMLMLAGTNFKNYGIYEDIANHMKMPLIDWEPSKSENIGK-TTENNPMIFSV--APS 147

  Fly   156 HTLLTLAYRDIMVYLNWTKVAIIYEEDYG------LFNLMHSST---ETKAEMYIRQASPDSYRQ 211
            ...|.:   |.:.|..|..|..|::....      :|:.:|..:   :...:.|:..:..:.:::
Worm   148 AEQLLI---DYIQYKGWRDVVYIHDGKNADRTLRTMFSYLHEKSPKYQLFVDNYVAPSDEEMFKE 209

  Fly   212 VLRAIRQK--------------EI-----YKIIVDTNPSH-IKSFFRSILQLQMNDHRYHYMFTT 256
            .|....::              ||     ..:|||...|: .::|.|::.:..:....|||:|:.
Worm   210 FLNEFHRRISTQHTLKSNDSSEEIDEPIPVNVIVDLEGSYRTRAFLRALEESVLVKKEYHYVFSN 274

  Fly   257 FDLETYDLEDFRYNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDS 321
            ||::..||..|.::.:|||.||:.|.::|::|:...:...:...|....:..|   |.:|...|:
Worm   275 FDVDETDLSGFHFSLINITIFRIFDKNNKKFLKTRAEFHDVYRGGFSNTDSIP---TAAAFAHDA 336

  Fly   322 VYA-----------FANGLHFLNLDNHQNFY--IKNLSCT--SDQ-------TWNDGISLYNQIN 364
            :..           ...|:...:...||.|.  .|.|.|.  .||       |:..|..:...|.
Worm   337 ILVAGKALQIAMNEHGKGIFDKSFVRHQLFNRGRKGLYCRPHEDQTESRQFETFEHGKKIAEAIK 401

  Fly   365 AAI---TDG-LTGTVQF--VEGRRNIFKLDILKLKQ---------EKIQKVGYWHPDDGVNISD- 413
            ..:   .|| |||.:||  |.|:|..|..:|:::|.         |:.|    |...:|..:..
Worm   402 KVVLTDKDGTLTGRIQFDKVTGKRTNFSAEIVEIKPGVNSLNSIWERFQ----WAEGEGFLLGGE 462

  Fly   414 ------------------PTAFYDSNIANITLVVMTREERPYVMVKE----DKNLTGNLRFEGFC 456
                              |:..:......:|::|     :|:||:|.    :..|.||.||||:|
Worm   463 RYVQEKKKDSSQTRKGILPSKPWQLRFNVVTVLV-----KPFVMLKRRNPGEPELKGNDRFEGYC 522

  Fly   457 IDLLKAIATQV-GFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVI 520
            ||||..:|..: ||:|.:.:...|.||....: .||:|::..|:...||:|||.:||...||..:
Worm   523 IDLLNLLAKNITGFEYDVFISDGNKYGSRQAD-GSWDGMIGYLLNETADVAVAPLTITQERERAV 586

  Fly   521 DFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNP 585
            ||:||||..||.|:.|.|..|...:||||.||.:.||::.|::|..||..:|:::.|||||.:..
Worm   587 DFSKPFMTTGISIMIKKPEKQEFNIFSFMEPLGMTIWIFTLSSYFGVSLTIFLVSWFSPYEKRIE 651

  Fly   586 HPCYKETDI-VENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLA 649
               :|..:. |.|:|::.||.||....|::||:.:.|:|.|.||...||:||.|||:||||||||
Worm   652 ---FKRGEFTVTNEFTLYNSLWFTLAAFMQQGTDILPRAVSGRIASSCWWFFTLIIVSSYTANLA 713

  Fly   650 AFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYM------------ 702
            ||||:|||..||||..|||.|.:|.||..|||||..||.||.:.:|:|||.:|
Worm   714 AFLTLERMTPPIESVEDLANQNKILYGVNEGGSTAAFFEDSIVPLYKKMWNFMVSTTQKQIELEK 778

  Fly   703 ----ENRKTAVFVKTYEDGIKRV--MEGSYAFLMESTMLDY-AVQRDCNLTQIGGLLDSKGYGIA 760
                .:....:||.:|.|||::|  .:|.||||:|.|..:| :.:|.|:..::|..|::.|||||
Worm   779 QSITNSTSNRIFVSSYADGIEKVRTSKGKYAFLLEETTNNYESGRRPCDTMKVGQNLNTLGYGIA 843

  Fly   761 TPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVL 825
            |..|:|.|..::||||.|.|||.::.|.:|||.:.|. |: ...|....:::|.:..:.|:|.:|
Worm   844 TKIGNPLRVSLNLAILYLSEKGELKKLENKWWYDRGQ-CD-TGTSDGGTSSSLNLSKVAGIFYIL 906

  Fly   826 LCGLALAVVVAIFEFCWNSRK-NLNTENQSLCSEMAEELRFAMHCHGSKSRHRPRKRS 882
            |.|:.|::..|:.||.:...| |...|...:.|....:......|..:|.:....:|:
Worm   907 LAGMVLSMCTALVEFLFRKNKENREKERNRMRSSRPLKPGILASCERAKQKQLQNRRT 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	82/384 (21%)
		ANF_receptor	61..393	CDD:279440	77/358 (22%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	170/393 (43%)
		Lig_chan	555..829	CDD:278489	123/293 (42%)
glr-2	NP_001021114.1	Periplasmic_Binding_Protein_Type_1	7..453	CDD:299141	81/379 (21%)
		Periplasmic_Binding_Protein_Type_2	491..875	CDD:304360	169/392 (43%)
		Lig_chan	621..910	CDD:278489	123/293 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820