DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and glr-4

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_001254126.1	Gene:	glr-4 / 174258	WormBaseID:	WBGene00001615	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	883	Identity:	302/883 - (34%)
Similarity:	451/883 - (51%)	Gaps:	134/883 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IILSILVISN-ALPPVIRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYVPRD 91
            |:|.|..|:| |......:|.|   ..|.|......:|||.|.|.|..  .:||:.:.|....|.
Worm    13 ILLVIFYIANSAADDRFHIGTI---ANRGSFAYEHLRYAIDRWNTEHG--AHTQIKFSIVSPIRY 72

  Fly    92 DSFRTTKKVCSQLEAGVQAIF-----GPTDALLASHVQSICEAYDIPHIE-GRIDLEYNSKEFSI 150
            |: ...:::|..::.|:.|:.     ...|:.|   ::|:|..::||.:. ....|..:..:|..
Worm    73 DN-NYEERMCEIMQQGIVAVVLSNEESEQDSQL---IKSMCHYFNIPCLSLQSTSLRDSVSDFVT 133

  Fly   151 NLYPSHTLLTLAYRDIMVYLNWTKVAIIYE-----EDYGLFNLMHSSTET---KAEMYIRQA--S 205
            .|.||......|..:.:..:.||...:.|:     ||...........:|   :..:.||:.  :
Worm   134 LLGPSRGAGARATSEFLDSMRWTGFLLAYQHGSDLEDLSPLMQYKQIVDTGGRRIHIKIRRLPNN 198

  Fly   206 PDSYRQVLRAI--RQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFR 268
            .|.|...|:.:  |.|:...||...|.:.:.:..:....|.|.:..:.|:||..||..  ||||.
Worm   199 TDDYEPFLKYVKTRLKQTNIIIHSNNITVLYNLLQQARGLNMAEPPFSYVFTNTDLSL--LEDFL 261

  Fly   269 YN------SVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFAN 327
            .|      ..|||                         ||..:...|.::|:.||..::||....
Worm   262 NNMYGASFHCNIT-------------------------GLQLVKNDPMMKTQLALTSEAVYVVGM 301

  Fly   328 GLHFLNLDNH---QNFYIKNLSCTSDQTWNDG---------ISLYNQINAAITDGLTGTVQFVEG 380
            .::.:....|   |:    ::.|.|...|:||         :.|.||        |||.|||...
Worm   302 SIYRMRELGHAPRQS----SIMCDSHDIWSDGRIMNEGIRKLKLRNQ--------LTGDVQFKSN 354

  Fly   381 --RRNIFKLDILKLKQEKIQKVGYWHPDDGVNISDPTAFYDSNIAN---------------ITLV 428
              |.:|....:.::..:.: |:|.|....|.|       :||..||               :.|.
Worm   355 GERDDIMYHGVGRINSQFV-KLGNWSEKRGWN-------FDSRYANRWEFDIDPDSEDLEGLHLR 411

  Fly   429 VMTREERPYVMVKEDKNLTGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNG 493
            |:...|.|:|:      .||..::||||||||..:...:.|.|.|..|.|..||:. .|:..|||
Worm   412 VVVYLEEPFVI------KTGENQYEGFCIDLLNEMTQVLKFNYTIIEVQDGTYGIE-DESGRWNG 469

  Fly   494 IVQELMERRADLAVASMTINYARESVIDFTKPFMNLGIGILFKVPTSQPT---RLFSFMNPLAIE 555
            |:..|....|||:::::||.|:|..|:|||.|||:|||.||. ..||:.|   .|::|:.||::.
Worm   470 IIGALQRHEADLSLSAVTITYSRAEVVDFTLPFMHLGISILL-ARTSEETDKGSLWTFLEPLSLT 533

  Fly   556 IWLYVLAAYILVSFALFVMARFSPYEWKN----PHPCYKETDIVENQFSISNSFWFITGTFLRQG 616
            :|:.:|.:|.:||:::.::|:||||||.|    ....::.....:|||::.|||||..|:.::||
Worm   534 VWISLLISYCIVSYSMHILAKFSPYEWYNLERIDERDFENIKNQKNQFTVLNSFWFTMGSLMQQG 598

  Fly   617 SGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGG 681
            |.:.|:|.:||::...|:.|..||||||||.||||||||||.:||||..|||.|.:|.||.|:.|
Worm   599 SDVIPRAAATRLIAVVWWMFTQIIISSYTAQLAAFLTVERMSTPIESTQDLANQQKIRYGVLKSG 663

  Fly   682 STMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKRVMEGSYAFLMESTMLDYAVQRDCNLT 746
            |||.|||:|||.:|::||..||:....|||.:..:||.||..|.||::|||:||:|.::|||.|.
Worm   664 STMDFFRESKIPMYERMWSVMESSSPGVFVNSSREGIARVKSGGYAYMMESSMLEYYLERDCELQ 728

  Fly   747 QIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKN--TGDVCN--RDDKSKE 807
            .|||||||||||||.|||||.||.:|..:|:|||:.|::.|.:|||::  .|..|.  ..:|:..
Worm   729 SIGGLLDSKGYGIALPKGSPLRDILSRTVLQLQERTILEALKNKWWRDRREGPSCGPPPSEKATN 793

  Fly   808 SKANALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSR 845
            ||.     :||.|:|.|||.||.:|.::|..|:|..||
Worm   794 SKP-----QNIFGIFYVLLTGLIVAFLLACGEYCIESR 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	91/403 (23%)
		ANF_receptor	61..393	CDD:279440	83/369 (22%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	180/390 (46%)
		Lig_chan	555..829	CDD:278489	138/281 (49%)
glr-4	NP_001254126.1	PBP1_iGluR_Kainate	30..385	CDD:107377	91/403 (23%)
		ANF_receptor	45..365	CDD:279440	83/364 (23%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:304360	179/372 (48%)
		Lig_chan	533..810	CDD:278489	138/281 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I858
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm14234
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.830