DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and gria3a

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	XP_005165152.1	Gene:	gria3a / 170452	ZFINID:	ZDB-GENE-020125-5	Length:	903	Species:	Danio rerio

Alignment Length:	864	Identity:	321/864 - (37%)
Similarity:	466/864 - (53%)	Gaps:	79/864 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SYIILSILVISN--ALPPVIRVGAIFTEDERESSIE--SAFKYAI--YRINKEKTLLPNTQLVYD 84
            |.::|..||:..  ..|..|.:|.:|    ..|:::  |||::|:  |..|:..|..| ..|.|:
Zfish     8 SVLLLPWLVLQTQAGFPNQINIGGLF----MRSTVQEHSAFRFAVQLYNTNQNITEKP-FHLNYN 67

  Fly    85 IEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYNSKEFS 149
            ::.:...:||..|...|||...||.||||..|....:.:.|.|.|.....|......: ...:|.
Zfish    68 VDNLESSNSFSVTHAFCSQFSRGVYAIFGFYDRRSMNTLTSFCGALHTSFITPSFPTD-TDVQFV 131

  Fly   150 INLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYG---LFNLMHSSTETKAEMYIRQ----ASPD 207
            :.:.||   |..|...::.:..|.|...:|:.|.|   |..:|.|:.....::..|.    ..|.
Zfish   132 LQMRPS---LRGALLSLLAHYKWEKFVYLYDTDRGFSILQAIMESAVMNNWQVTARSVGNIVDPL 193

  Fly   208 SYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSV 272
            .||:::..:.:::..:.::|.....|.|....::....|...|||:..........|:.......
Zfish   194 EYRRIIEEMDRRQEKRFLIDCEVERINSILEQVVIAGKNSRGYHYILANLGFTNMSLDKVFSGGA 258

  Fly   273 NITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHFLNLDNH 337
            |||.|::::.||....:.:.:.::|..........|| ::..|||..|::...|....:|   ..
Zfish   259 NITGFQIINPDSPIVQQFLQRWERLDEREFPESRSSP-LKYTSALTHDAILVIAEAFRYL---RR 319

  Fly   338 QNFYIKNLSCTSD------QTWNDGISLYNQINAAITDGLTGTVQFVE-GRRNIFKLDILKLKQE 395
            |...|.......|      ..|:.||.:...:......|:||.:||.. |||:.:.:|:.::|..
Zfish   320 QRVDISRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDSFGRRSNYTVDVYEMKPG 384

  Fly   396 KIQKVGYWHP-DDGVNISDPTAFYD-SNIANITLVVMTREERPYVMVKED-KNLTGNLRFEGFCI 457
            ..:|:|||:. :..|.|.:.....: |::.|.|:||.|..|.||||.|.: ..|.||.|:||:|:
Zfish   385 GARKIGYWNEFEKFVYIVEQQVTNESSSVENRTIVVTTIMEAPYVMYKRNYMQLEGNDRYEGYCV 449

  Fly   458 DLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVIDF 522
            ||...||..||.:||:.:|.|..||...|||.:|||:|.||:..|||:|||.:||...||.||||
Zfish   450 DLASEIAKHVGIKYKLSIVADGKYGARDPETKTWNGMVGELVYGRADIAVAPLTITLVREEVIDF 514

  Fly   523 TKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEW----- 582
            :||||:|||.|:.|.|......:|||::|||.|||:.::.|||.||..||:::|||||||
Zfish   515 SKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLDDN 579

  Fly   583 ---KNPH----PCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLII 640
               |:|.    |        .|.|.|.||.||..|.|::||..::|::.|.|||||.|:||.|||
Zfish   580 EETKDPQTPPDP--------PNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLII 636

  Fly   641 ISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENR 705
            |||||||||||||||||:||||||.|||:||||:||||:.|||..|||.|||.:|:|||.||::.
Zfish   637 ISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSA 701

  Fly   706 KTAVFVKTYEDGIKRV--MEGSYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGIATPKGSPW 767
            :.:|||||..||:.||  .:|.:|||:||||.:|..|| .|:..::||.|||||||:||||||..
Zfish   702 EPSVFVKTTPDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSAL 766

  Fly   768 RDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGV--ENIG----------- 819
            |..::||:|:|.|:||:..|.:|||.:.|:...:|..||.|....|.|  .||.
Zfish   767 RTPVNLAVLKLSEQGILDKLKNKWWYDKGECGTKDSGSKVSLLTHLTVLPTNISIYHKHHNEFPV 831

  Fly   820 -------GVFVVLLCGLAL 831
                   .:|::..|..|:
Zfish   832 AGFTFFWPLFILFTCAQAI 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	90/384 (23%)
		ANF_receptor	61..393	CDD:279440	81/347 (23%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	209/384 (54%)
		Lig_chan	555..829	CDD:278489	152/308 (49%)
gria3a	XP_005165152.1	PBP1_iGluR_AMPA_GluR3	28..399	CDD:107382	90/383 (23%)
		ANF_receptor	39..382	CDD:279440	82/351 (23%)
		PBP2_iGluR_AMPA	415..797	CDD:270433	211/389 (54%)
		Lig_chan	547..810	CDD:278489	146/270 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591876
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650