DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and gria2b

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	XP_005157361.1	Gene:	gria2b / 170451	ZFINID:	ZDB-GENE-020125-4	Length:	897	Species:	Danio rerio

Alignment Length:	878	Identity:	323/878 - (36%)
Similarity:	497/878 - (56%)	Gaps:	61/878 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ICCSYIILSILVISNALPPVIRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEY 87
            ||   :|..:|.::....|.:::|.:|.....:       :|:.:||...:......:|...|:.
Zfish     9 IC---LIALLLGMTTGGSPSVQIGGLFPRGADQ-------EYSAFRIGMVQFGTAEFRLTPHIDN 63

  Fly    88 VPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYNSKEFSINL 152
            :...:||..|...|||...||.||||..|....:.:.|.|....:..|.....|:.| ::|.|.:
Zfish    64 LEVANSFAVTNCFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPLDGN-QQFIIQM 127

  Fly   153 YP--SHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNL---MHSSTETKAEMYI-------RQAS 205
            .|  ...||:|     :.|..|.|.|.:|:.|.||..|   :.::.|.|.::..       .:..
Zfish   128 RPDIKGPLLSL-----IEYYKWDKFAYLYDSDRGLTTLQVVLDTAAEKKWQVTAINVGNMKDERK 187

  Fly   206 PDSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYN 270
            .::||.:.:.:..|:..::|:|.....:|.....::.:..:...|||:.........||...:|.
Zfish   188 DEAYRSLFQDLENKKERRVILDCEQDKVKDIMEQVITIGRHVKGYHYIIANLGFVDGDLSKIQYG 252

  Fly   271 SVNITAFRLVDVDS---KRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHFL 332
            ..|::.|::||.|.   .::.:....:::.::.|.|:     .|:..|||.:|:|........:|
Zfish   253 GANVSGFQIVDFDDPLVSKFDQRWEALEEKEYPGADS-----KIRYTSALTYDAVQVMTEAFRYL 312

  Fly   333 -----NLDNHQNFYIKNLSCTSDQT--WNDGISLYNQINAAITDGLTGTVQFVE-GRRNIFKLDI 389
                 ::....|    |..|.::..  |..|:.:...:.....|||||.:||.: |:|..:.:::
Zfish   313 HKQRIDISRRAN----NGDCLANPAVPWAQGVEIERALKQVRVDGLTGNIQFDQYGKRVNYTVNV 373

  Fly   390 LKLKQEKIQKVGYWHPDDGVNISDPTAFYDS--NIANITLVVMTREERPYVMVKEDKNL-TGNLR 451
            ::||.....|:|||:..|.:.::....|.:.  .:.|.|::|.|..|.||||:|::.:| ..|.|
Zfish   374 MELKSNGAVKIGYWNEVDKMVVTKSDLFPNDTMGLENKTVIVTTILEAPYVMLKKNADLFMDNER 438

  Fly   452 FEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYAR 516
            :||:|:||...||...||:|::::|.|..||....||..|||:|.||:..:||:|||.:||...|
Zfish   439 YEGYCVDLAAEIAKHCGFKYQLKIVGDGKYGARDAETKIWNGMVGELVYGKADIAVAPLTITLVR 503

  Fly   517 ESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYE 581
            |.||||:||||:|||.|:.|.|......:|||::|||.|||:.::.|||.||..||:::||||||
Zfish   504 EEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYE 568

  Fly   582 WKNPHPCYK----ETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIIS 642
            |....  |:    :|:...|:|.|.||.||..|.|:|||..::|::.|.|||||.|:||.|||||
Zfish   569 WHTEE--YEDGQIQTNESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIIS 631

  Fly   643 SYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKT 707
            |||||||||||||||:||||||.|||:||||:||||:.|||..|||.|||.::.|||.||:..:.
Zfish   632 SYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIALFDKMWTYMKGAEP 696

  Fly   708 AVFVKTYEDGIKRV--MEGSYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGIATPKGSPWRD 769
            :|||||..:|:.||  .:|.||:|:||||.:|..|| .|:..::||.||||||||||||||..|:
Zfish   697 SVFVKTTAEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRN 761

  Fly   770 KISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVV 834
            .::||:|:|.|:|::..|.:|||.:.|:..:....||| |.:||.:.|:.|||.:|:.||.||::
Zfish   762 AVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKE-KTSALSLSNVAGVFYILVGGLGLAML 825

  Fly   835 VAIFEFCWNSRKNLNTENQSLCSEMAEELRFAM 867
            ||:.|||:.||........:....|..:.|.::
Zfish   826 VALVEFCYKSRAEAKRMKVTFSDAMRSKARLSV 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	89/388 (23%)
		ANF_receptor	61..393	CDD:279440	80/354 (23%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	202/376 (54%)
		Lig_chan	555..829	CDD:278489	151/280 (54%)
gria2b	XP_005157361.1	PBP1_iGluR_AMPA_GluR2	27..395	CDD:107384	89/389 (23%)
		ANF_receptor	55..377	CDD:279440	77/336 (23%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	204/381 (54%)
		Lig_chan	542..820	CDD:278489	151/280 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591866
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650