DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11155 and gria2a

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	XP_005170953.1	Gene:	gria2a / 170450	ZFINID:	ZDB-GENE-020125-3	Length:	893	Species:	Danio rerio

Alignment Length:	865	Identity:	319/865 - (36%)
Similarity:	486/865 - (56%)	Gaps:	68/865 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PVIRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYVPRDDSFRTTKKVCSQLE 105
            |.:::|.:|.....:       :|:.:||...:......:|...|:.:...:||..|...|||..
Zfish    20 PSVQIGGLFPRGADQ-------EYSAFRIGMVQFGTAEFRLTPHIDNLEVANSFAITNCFCSQFS 77

  Fly   106 AGVQAIFGPTDALLASHVQSICEAYDIPHIEGRIDLEYNSKEFSINLYP--SHTLLTLAYRDIMV 168
            .||.||||..|....:.:.|.||...:..|......: ...:|.:.:.|  ...|::|     :.
Zfish    78 RGVYAIFGFYDKKSVNTITSFCETLHVSFITPSFPAD-GLNQFVLQMRPDIKGPLISL-----VE 136

  Fly   169 YLNWTKVAIIYEEDYGLFNL---MHSSTETKAEMYI-------RQASPDSYRQVLRAIRQKEIYK 223
            |..|.|.|.:|:.|.||..|   :.::.|.|.::..       .:...::||.:.:.:..|...:
Zfish   137 YYKWEKFAYLYDSDRGLSTLQAVLDTAAERKWQVTAINVGNLKDEWKDEAYRSLFQDLENKNERR 201

  Fly   224 IIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVNITAFRLVDVDS---K 285
            :|:|.....:|.....::.:..:...|||:...|.....||...:|...|::.|::||.|.   .
Zfish   202 VILDCEQDKVKDIMEQVITIGRHVKGYHYIIANFGFVDGDLSKIQYGGANVSGFQIVDFDDPLVA 266

  Fly   286 RYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHFLNLDNHQNFYI----KNLS 346
            ::.:....:::.::.|.|:     .|:..|||.:|:|........||   :.|...|    .|..
Zfish   267 KFDQRWEALEEKEYPGADS-----RIRYTSALTYDAVQVMTEAFRFL---HKQRIDISRRGNNGD 323

  Fly   347 CTSDQT--WNDGISLYNQINAAITDGLTGTVQFVE-GRRNIFKLDILKLKQEKIQKVGYWHPDDG 408
            |.::..  |..|:.:...:.....|||||.:||.: |||..:.:::::||.....|:|||:..|.
Zfish   324 CLANPAVPWAQGVEIERALKQVRVDGLTGNIQFDQYGRRVNYTVNVMELKNSGPVKIGYWNEMDK 388

  Fly   409 VNISDPTAFYDSNIA--NITLVVMTREERPYVMVKEDKNL-TGNLRFEGFCIDLLKAIATQVGFQ 470
            :.::....|.:..:.  |.|::|.|..|.||||:|::..| |.|.|:||:|:||...||...||:
Zfish   389 MAVTKSDLFPNDTMGMENKTVIVTTILEAPYVMLKKNAELFTDNERYEGYCVDLAAEIAKHCGFK 453

  Fly   471 YKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVIDFTKPFMNLGIGILF 535
            |::.:|.|..||....||..|||:|.||:..:||:|||.:||...||.||||:||||:|||.|:.
Zfish   454 YQLRIVADGKYGARDAETKIWNGMVGELVYGKADIAVAPLTITLVREEVIDFSKPFMSLGISIMI 518

  Fly   536 KVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPHPCYKETDIVE---- 596
            |.|......:|||::|||.|||:.::.|||.||..||:::|||||||        .|:..|
Zfish   519 KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEW--------HTEEFEDGQL 575

  Fly   597 ------NQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVE 655
                  |:|.|.||.||..|.|::||..::|::.|.|||||.|:||.||||||||||||||||||
Zfish   576 GPSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVE 640

  Fly   656 RMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKR 720
            ||:||||||.|||:||||:||||:.|||..|||.|||.::.|||:||::.:.:||||...:|:.|
Zfish   641 RMVSPIESAEDLAKQTEIAYGTLDAGSTKEFFRRSKIALFDKMWQYMKSAEPSVFVKNTVEGVLR 705

  Fly   721 V--MEGSYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKG 782
            |  .:|.||:|:||||.:|..|| .|:..::||.||||||||||||||..|:.::||:|:|.|:|
Zfish   706 VRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNAVNLAVLKLNEQG 770

  Fly   783 IIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSRKN 847
            ::..|.:|||.:.|:..:...:||| |.:||.:.|:.|||.:|:.||.||::||:.|||:.||..
Zfish   771 LLDKLKNKWWYDKGECGSGGGESKE-KTSALSLSNVAGVFYILVGGLGLAMLVALVEFCYKSRAE 834

  Fly   848 LNTENQSLCSEMAEELRFAM 867
            ......:....|..:.|.::
Zfish   835 AKRMKMTFTDAMRSKARLSI 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	90/387 (23%)
		ANF_receptor	61..393	CDD:279440	81/353 (23%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	201/382 (53%)
		Lig_chan	555..829	CDD:278489	149/286 (52%)
gria2a	XP_005170953.1	Periplasmic_Binding_Protein_Type_1	23..391	CDD:299141	90/388 (23%)
		ANF_receptor	51..373	CDD:279440	78/335 (23%)
		PBP2_iGluR_AMPA	406..783	CDD:270433	202/384 (53%)
		Lig_chan	538..816	CDD:278489	149/286 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591865
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650