Protein Alignment CG11155 and Grin2a

DIOPT Version :10

• Sequence 1: NP_651941.2
• Gene: CG11155 / 43822
• FlyBaseID: FBgn0039927
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 684
• Identity: 188/684 - (27%)
• Similarity: 312/684 - (45%)
• Gaps: 146/684 - (21%)

  Fly   292 NQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHFLNLDNHQNFYIKNLSCTSDQTWNDG 356
            :.::|..:  :.....|.|.|||..         ...||.|    ||  ::.|:      || ||
Mouse   305 SMLEKFSY--IPEAKASCYGQTEKP---------ETPLHTL----HQ--FMVNV------TW-DG 345

  Fly   357 ISLYNQINAAITDGLTGTVQFVEGRRNIFKLDILKL-KQEKIQKVGYWHPDDGVNISDPT----- 415
            ..|      :.|:         ||.:...:|.::.| |..:.:|||.|. :..:::....
Mouse   346 KDL------SFTE---------EGYQVHPRLVVIVLNKDREWEKVGKWE-NQTLSLRHAVWPRYK 394

  Fly   416 AFYDSNIANITLVVMTREERPYVMVKEDKNLTG-----------------------NLR--FEGF 455
            :|.|....:..|.::|.||.|:|:|::...||.                       |::  .:||
Mouse   395 SFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGF 459

  Fly   456 CIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVI 520
            |||:||.::..|.|.|.:.||.:..:|..:  .|.|||::.|::.:||.:||.|:|||..|..|:
Mouse   460 CIDILKKLSRTVKFTYDLYLVTNGKHGKKV--NNVWNGMIGEVVYQRAVMAVGSLTINEERSEVV 522

  Fly   521 DFTKPFMNLGIGILFKVP--TSQPTRLFSFMNPLAIEIWLYVLAAYILVS-FALFVMARFSPYEW 582
            ||:.||:..||.::....  |..|:   :|:.|.:..:|:.:....::|| .|:||...|||..:
Mouse   523 DFSVPFVETGISVMVSRSNGTVSPS---AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGY 584

  Fly   583 -------KNPH-PCYKETDIVENQFSISNSFWFITGTFLRQGSGL-NPKATSTRIVGGCWFFFCL 638
                   |.|| |          .|:|..:.|.:.|........: |||.|:::|:...|.||.:
Mouse   585 NRNLAKGKAPHGP----------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAV 639

  Fly   639 IIISSYTANLAAFLTVERMISPIESASDLAEQTEISY------GTLEGGSTMTFFRDSKIGIYQK 697
            |.::|||||||||:..|..:..:...||...|....|      ||:..|||....|::    |..
Mouse   640 IFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNN----YPY 700

  Fly   698 MWRYMENRKTAVFVKTYEDGIKRVMEGSY-AFLMESTMLDYAVQRD--CNLTQIGG--LLDSKGY 757
            |.:||    |....:..||.:..:..|.. ||:.::.:|:|...||  |.|..||.  :..:.||
Mouse   701 MHQYM----TKFNQRGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGY 761

  Fly   758 GIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVF 822
            |||..|||||:.:|.||:|:....|.::.|...|.  || :|:  ::..|..::.|.::|:.|||
Mouse   762 GIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL--TG-ICH--NEKNEVMSSQLDIDNMAGVF 821

  Fly   823 VVLLCGLALAVVVAIFE--FCWNSR---KNLNTENQSLCSEMAEELRFAMH-CH----------- 870
            .:|...:||:::..|:|  |.|..|   ..:.::...|...::..:...:| .|
Mouse   822 YMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFN 886

  Fly   871 --GSKSRHRPRKRSCLNCSSVPTYVPSNVSTSNV 902
              ||:|......||..|.|::     ||:::|.:
Mouse   887 LTGSQSNMLKLLRSAKNISNM-----SNMNSSRM 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..413	CDD:380605	27/121 (22%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	129/416 (31%)
		Lig_chan	554..828	CDD:459656	91/294 (31%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601	27/121 (22%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	132/426 (31%)
		NMDAR2_C	839..1464	CDD:463148	16/82 (20%)