Protein Alignment CG11155 and Grin1

DIOPT Version :10

• Sequence 1: NP_651941.2
• Gene: CG11155 / 43822
• FlyBaseID: FBgn0039927
• Length: 910
• Species: Drosophila melanogaster
• Sequence 2: NP_001359487.1
• Gene: Grin1 / 14810
• MGIID: 95819
• Length: 959
• Species: Mus musculus
• Alignment Length: 923
• Identity: 234/923 - (25%)
• Similarity: 391/923 - (42%)
• Gaps: 182/923 - (19%)

  Fly    40 PPVIRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYVPRDDSFRTTKKVCSQL 104
            |.::.:||:.:..:.|.....|...|..|....|..|..|.:.:      :.::.:....||..|
Mouse    24 PKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTH------KPNAIQMALSVCEDL 82

  Fly   105 -EAGVQAIF-----GPTDALLASHVQSICEAYDIP--HIEGRIDLEYNSKEFSINL---YPSHTL 158
             .:.|.||.     .|.|....:.|......|.||  .:..|:.: |:.|...::.   .|.::.
Mouse    83 ISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSI-YSDKSIHLSFLRTVPPYSH 146

  Fly   159 LTLAYRDIMVYLNWTKVAIIYEEDY-------GLFNLMHS-STETKAEMY--IRQASPDSYR--- 210
            .:..:.::|...||..:.::..:|:       .|..|:.. .:::|...|  :.|.|.|:.|
Mouse   147 QSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEERESKSKKRNYENLDQLSYDNKRGPK 211

  Fly   211 ---------------QVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLE 260
                           .:|...|..|...||:..:.....:.:|:...|.|....|
Mouse   212 AEKVLQFDPGTKNVTALLMEARDLEARVIILSASEDDAATVYRAAAMLNMTGSGY---------- 266

  Fly   261 TYDLEDFRYNSVNITAFRLVDVDSKRYLE--VINQMQKLQHNGLDTINGSPYIQTESALMFDSVY 323
                       |.:...|.:..::.||..  :|         ||..|||    :.|||.:.|:|.
Mouse   267 -----------VWLVGEREISGNALRYAPDGII---------GLQLING----KNESAHISDAVG 307

  Fly   324 AFANGLHFLNLDNHQNFYIKNLSCTSD-QTWNDGISLYNQI--NAAITDGLTGTVQFVE-GRRNI 384
            ..|..:|  .|...:|.......|..: ..|..| .|:.::  ::...||:||.|:|.| |.|..
Mouse   308 VVAQAVH--ELLEKENITDPPRGCVGNTNIWKTG-PLFKRVLMSSKYADGVTGRVEFNEDGDRKF 369

  Fly   385 FKLDILKLKQEKIQKVGYWH-----PDD------GVNISDPTAFYDSNIANITLVVMTREERPYV 438
            ....|:.|:..|:.:||.::     |:|      |.....|..:..|.    .|.::|..:.|:|
Mouse   370 ANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMST----RLKIVTIHQEPFV 430

  Fly   439 MVKEDKNLTGNLRFE---------------------------------GFCIDLLKAIATQVGFQ 470
            .||...: .|..:.|                                 |||:|||..:|..:.|.
Mouse   431 YVKPTMS-DGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCVDLLIKLARTMNFT 494

  Fly   471 YKIELVPDNMYGVYIPETNS----WNGIVQELMERRADLAVASMTINYARESVIDFTKPFMNLGI 531
            |::.||.|..:|......||    |||::.||:..:||:.||.:|||..|...|:|:|||...|:
Mouse   495 YEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGL 559

  Fly   532 GILFK--VPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPY-EWKNPHPCYKETD 593
            .||.|  :|.|   .|.|||.|....:||.|..:..:|:..|:::.||||: .:|     ....:
Mouse   560 TILVKKEIPRS---TLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFK-----VNSEE 616

  Fly   594 IVENQFSISNSFWFITGTFLRQGSGLN-PKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERM 657
            ..|:..::|::.||..|..|..|.|.. |::.|.||:|..|..|.:||::||||||||||.::|.
Mouse   617 EEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP 681

  Fly   658 ISPIESASD--LAEQTE-ISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYE---D 716
            ...|...:|  |...:: ..|.|::..|...:|| .::.: ..|:|:||..       .||   :
Mouse   682 EERITGINDPRLRNPSDKFIYATVKQSSVDIYFR-RQVEL-STMYRHMEKH-------NYESAAE 737

  Fly   717 GIKRVMEGS-YAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQE 780
            .|:.|.:.. :||:.:|.:|::...:.|:|...|.|....|:||...|.|||:..:||:||:..|
Mouse   738 AIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHE 802

  Fly   781 KGIIQILYDKWWKNTGDVCNRDDKSKESKANA---LGVENIGGVFVVLLCGLALAVVVAIFEFCW 842
            .|.::.| ||.|....: |       :|::||   |..||:.|||:::..|:...:.:...|..:
Mouse   803 NGFMEDL-DKTWVRYQE-C-------DSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAY 858

  Fly   843 NSRKNLNTENQSL 855
            ...|:...:...|
Mouse   859 KRHKDARRKQMQL 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..413	CDD:380605	86/424 (20%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	130/416 (31%)
		Lig_chan	554..828	CDD:459656	89/285 (31%)
Grin1	NP_001359487.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	85/422 (20%)
		PBP2_iGluR_NMDA_Nr1	416..820	CDD:270437	133/434 (31%)
		CaM_bdg_C0	856..884	CDD:402271	2/16 (13%)