DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and Grik3

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_001074566.1	Gene:	Grik3 / 14807	MGIID:	95816	Length:	919	Species:	Mus musculus

Alignment Length:	910	Identity:	393/910 - (43%)
Similarity:	572/910 - (62%)	Gaps:	62/910 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ICCSYIILSILVISNALPPVIRVGAIFT-EDERESSI----ESAFKYAIYRINKEKTLLPNTQLV 82
            :.|::.|..    |..:|.|||:|.||. .|...:.:    |.||:::...||:.:||||||.|.
Mouse    20 LVCAFWIPD----SRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLT 80

  Fly    83 YDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGR-----IDLE 142
            |||:.:...|||..|||.|.||..||.|||||:.....:.|||||.|.::|||:.|     :|
Mouse    81 YDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLD-- 143

  Fly   143 YNSKEFSINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNLMH---SSTETKAEMYIRQA 204
             |...|.:||||.:..|:.|..|::..|.|....::|::..||..|..   :.:.....:.|||.
Mouse   144 -NKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQL 207

  Fly   205 SPDS--YRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDF 267
            ..||  .|.:|:.:::...::||.|.:.:......:..:.:.|....||::|||.||...|||.:
Mouse   208 PIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPY 272

  Fly   268 RYNSVNITAFRLVDVDSKRYLEVINQ--MQKLQ-----HNGLDTINGSPYIQTESALMFDSVYAF 325
            ||:.||:|.||:::||:.....::.:  |::||     .:||  ::|  .:.|::||::|:|
Mouse   273 RYSGVNLTGFRILNVDNPHVSAIVEKWAMERLQAAPRAESGL--LDG--VMMTDAALLYDAV--- 330

  Fly   326 ANGLHFLNL--DNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQF--VEGRRNIFK 386
                |.:::  .......:.:|.|...:.|..|....|.|..|..:||||.:.|  ..|.|..|.
Mouse   331 ----HIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFD 391

  Fly   387 LDILKLKQEKIQKVGYWHPDDGVNISDPTAFYDSNI----ANITLVVMTREERPYVMV-KEDKNL 446
            |||:.||::.::|||.|.|.||:||::.......|:    .|.:|:|.|..|.|:||. |.|:.|
Mouse   392 LDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTL 456

  Fly   447 TGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMT 511
            .||.||||:||||||.:|..:||.|:|.||.|..||.. .:...|||:|:||::.:||||||.:|
Mouse   457 YGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQ-DDKGQWNGMVKELIDHKADLAVAPLT 520

  Fly   512 INYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMAR 576
            |.:.||..|||:||||.||:.||::.|......:|||:|||:.:||:|||.||:.||..|||:||
Mouse   521 ITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIAR 585

  Fly   577 FSPYEWKNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIII 641
            ||||||.:.|||...:::|||.|::.|||||..|:.::|||.|.|||.||||:||.|:||.||||
Mouse   586 FSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIII 650

  Fly   642 SSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRK 706
            ||||||||||||||||.|||:||.|||:||:|.||.::.|:|||||:.|||..::|||.:|.::.
Mouse   651 SSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKP 715

  Fly   707 TAVFVKTYEDGIKRVMEGSYAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKI 771
            :|: ||..|:||:|.:...||.|||||.::|..||:|||||||||:|||||||.||.|||:||||
Mouse   716 SAL-VKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKI 779

  Fly   772 SLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVA 836
            ::|||:|||:..:.|:.:|||:.:|  | .::::||  |:|||::.|||:|:||..||.|:|:||
Mouse   780 TIAILQLQEEDKLHIMKEKWWRGSG--C-PEEENKE--ASALGIQKIGGIFIVLAAGLVLSVLVA 839

  Fly   837 IFEFCWNSRKNLNTENQSLCSEMAEELRFAMHCHGSKSRHRPRKRSCLNCSSVPTYVPSNVSTSN 901
            :.||.:..||....|.:|.||.:|:|:||::.|. .:.:|:|:....:...:|     .|:.|.|
Mouse   840 VGEFIYKLRKTAEREQRSFCSTVADEIRFSLTCQ-RRLKHKPQPPMMVKTDAV-----INMHTFN 898

Fly 902 901
Mouse 899 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	131/391 (34%)
		ANF_receptor	61..393	CDD:279440	116/352 (33%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	213/369 (58%)
		Lig_chan	555..829	CDD:278489	161/273 (59%)
Grik3	NP_001074566.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388	134/396 (34%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	213/369 (58%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846664
Domainoid	1	1.000	362	1.000	Domainoid score	I943
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	LDO	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.750