DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and Grik2

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	XP_011241422.1	Gene:	Grik2 / 14806	MGIID:	95815	Length:	943	Species:	Mus musculus

Alignment Length:	913	Identity:	394/913 - (43%)
Similarity:	570/913 - (62%)	Gaps:	77/913 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IILSILVI--SNALPPVIRVGAIF--TEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYV 88
            ::|.:|.|  |.....|:|.|.||  .|.....:.|.||::|:..||:.:||||||.|.||.:.:
Mouse    19 VLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKI 83

  Fly    89 PRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGR--IDLEYNSKEFSIN 151
            ...|||..:||.|.||..||.|||||:.:..|:.|||||.|..:|||:.|  ..:..|...|.::
Mouse    84 NLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVS 148

  Fly   152 LYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLF---NLMHSSTETKAEMYIRQASPDS--YRQ 211
            |||..:.|:.|..|::.:..|..|.::|::..||.   .|:.:.:.....:.|||...|:  .:.
Mouse   149 LYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKP 213

  Fly   212 VLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVNITA 276
            :|:.:::.:.:.:|.|.:........:..|.:.|....|||:|||.||...|:|.:||:.||:|.
Mouse   214 LLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTG 278

  Fly   277 FRLVDVDSKRYLEVINQ--MQKLQ-----HNGLDTINGSPYIQTESALMFDSVYAFANGLHFLNL 334
            ||:::.::.:...:|.:  |::||     .:||  ::|  ::.|::|||:|:|:..:     :.:
Mouse   279 FRILNTENTQVSSIIEKWSMERLQAPPKPDSGL--LDG--FMTTDAALMYDAVHVVS-----VAV 334

  Fly   335 DNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQF--VEGRRNIFKLDILKLKQEKI 397
            .......:.:|.|...:.|..|....:.|..|..:||||.:.|  ..|.|..|.||::.||:|.:
Mouse   335 QQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGL 399

  Fly   398 QKVGYWHPDDGVNISD-----PTAFYDSNIANITLVVMTREERPYVMVKE-DKNLTGNLRFEGFC 456
            :|:|.|.|..|:|:::     |....|| ::|.:|:|.|..|.|||:.|: ||.|.||.||||:|
Mouse   400 EKIGTWDPSSGLNMTESQKGKPANITDS-LSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYC 463

  Fly   457 IDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVID 521
            ||||:.::|.:||.|:|.||.|..||........|||:|:||::.:||||||.:.|.|.||.|||
Mouse   464 IDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVID 528

  Fly   522 FTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMAR---------- 576
            |:||||.|||.||::.|......:|||:|||:.:||:|:|.||:.||..|||:||
Mouse   529 FSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARQSKFSWFKYP 593

  Fly   577 -------------------------FSPYEWKNPHPCYKETDIVENQFSISNSFWFITGTFLRQG 616
                                     ||||||.|||||..::|:|||.|::.|||||..|..::||
Mouse   594 NCSHYHHSQRCLCTQHLESYMELCLFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG 658

  Fly   617 SGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGG 681
            |.|.|||.|||||||.|:||.||||||||||||||||||||.|||:||.|||:||:|.||.:|.|
Mouse   659 SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDG 723

  Fly   682 STMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKRVMEGSYAFLMESTMLDYAVQRDCNLT 746
            :|||||:.|||..|.|||.:|.:|:.:|.||:.|:||:||:...||||||||.:::..||:||||
Mouse   724 ATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLT 788

  Fly   747 QIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKAN 811
            |||||:||||||:.||.|||:||||::|||:|||:|.:.::.:|||:..|  | .:::|||  |:
Mouse   789 QIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG--C-PEEESKE--AS 848

  Fly   812 ALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSRKNLNTENQSLCSEMAEELRFAMHCHGSKSRH 876
            ||||:||||:|:||..||.|:|.||:.||.:.|:||...|.:|.||.|.||||.::.|. .:.:|
Mouse   849 ALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQ-RRLKH 912

  Fly   877 RPR 879
            :|:
Mouse   913 KPQ 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	123/383 (32%)
		ANF_receptor	61..393	CDD:279440	109/347 (31%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	221/404 (55%)
		Lig_chan	555..829	CDD:278489	170/308 (55%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	124/385 (32%)
Grik2	XP_011241422.1	Periplasmic_Binding_Protein_Type_2	430..835	CDD:389745	221/404 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846684
Domainoid	1	1.000	362	1.000	Domainoid score	I943
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860