DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and Grik1

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	908	Identity:	411/908 - (45%)
Similarity:	576/908 - (63%)	Gaps:	64/908 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SYIILSIL--VISNALPPVIRVGAIF--TEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIE 86
            |:.:|..|  ::....|.|:|:|.||  .|:|..:..|.|||:|:..||:.:||:|||.|.|||:
Mouse    18 SWTLLYFLCYILPQTSPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQ 82

  Fly    87 YVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGR-----IDLEYNSK 146
            .:...|||..:::.|.||..||.|:|||:.:...|.|||||.|.::|||:.|     :|   |..
Mouse    83 RINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVD---NRD 144

  Fly   147 EFSINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLF---NLMHSSTETKAEMYIRQ---AS 205
            .|.|||||.:..::.|..|:::|.||..|.::||:..||.   .|:.:.:....::.|||   .:
Mouse   145 LFYINLYPDYAAISRAVLDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGN 209

  Fly   206 PDSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYN 270
            .|: :.:|:.:::.:.:.:|.|.:........:.||.:.|....|||.|||.||...|||.:||:
Mouse   210 KDA-KPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYS 273

  Fly   271 SVNITAFRLVDVDSKRYLEVINQ--MQKLQ-----HNGLDTINGSPYIQTESALMFDSVYAFANG 328
            .||:|.|||:::|:.....:|.:  |::||     ..||  ::|  .:.||:|||:|:||..|..
Mouse   274 GVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGL--LDG--VMTTEAALMYDAVYMVAIA 334

  Fly   329 LHFLNLDNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQF--VEGRRNIFKLDILK 391
            .|     ......:.:|.|...:.|..|....|.|..|..|||||.:.|  .:|.|..|.|||:.
Mouse   335 SH-----RASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGRITFNKTDGLRKDFDLDIIS 394

  Fly   392 LKQE--------------KI-QKVGYWHPDDGVNISDPTAFYDSNI----ANITLVVMTREERPY 437
            ||:|              |: :|:|.|:.:.|:|::|......:||    ||.||:|.|..|.||
Mouse   395 LKEEGTEKASGEVSKHLYKVWKKIGIWNSNSGLNMTDGNRDRSNNITDSLANRTLIVTTILEEPY 459

  Fly   438 VMV-KEDKNLTGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMER 501
            ||. |.||.|.||.||||:|:||||.::..:||.|.::||||..||.. .:...|||:|:||::.
Mouse   460 VMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQ-NDKGEWNGMVKELIDH 523

  Fly   502 RADLAVASMTINYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYIL 566
            |||||||.:||.|.||.||||:||||.|||.||::.|......:|||:|||:.:||:|||.|.:.
Mouse   524 RADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLG 588

  Fly   567 VSFALFVMARFSPYEWKNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGG 631
            ||..|||:|||:||||.|||||..::|:|||.|::.|||||..|..::|||.|.|||.|||||||
Mouse   589 VSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGG 653

  Fly   632 CWFFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQ 696
            .|:||.||||||||||||||||||||.|||:||.|||:||:|.||.:..|||||||:.|||..|:
Mouse   654 IWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYE 718

  Fly   697 KMWRYMENRKTAVFVKTYEDGIKRVMEGSYAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIAT 761
            |||.:|.:|:.:..||..::||:||:...||.|||||.::|..||:|||||||||:||||||:.|
Mouse   719 KMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGT 783

  Fly   762 PKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLL 826
            |.|||:||||::|||:|||:|.:.::.:|||:..|  |..:| |||  |:|||||||||:|:||.
Mouse   784 PIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG--CPEED-SKE--ASALGVENIGGIFIVLA 843

  Fly   827 CGLALAVVVAIFEFCWNSRKNLNTENQSLCSEMAEELRFAMHCHGSKSRHRPRKRSCLNCSSV 889
            .||.|:|.|||.||.:.||||.:.|.:...|.:....|..:..||||:.....:: ||:.:::
Mouse   844 AGLVLSVFVAIGEFIYKSRKNNDIEQKGKSSRLRFYFRNKVRFHGSKTESLGVEK-CLSFNAI 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	138/402 (34%)
		ANF_receptor	61..393	CDD:279440	123/351 (35%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	221/369 (60%)
		Lig_chan	555..829	CDD:278489	169/273 (62%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	139/405 (34%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	221/369 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846569
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68992
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.760