DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and Grid2

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	964	Identity:	258/964 - (26%)
Similarity:	452/964 - (46%)	Gaps:	156/964 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VIRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYVPRDDSFRTTKKVCSQLEA 106
            :|.:||||  ||.....:..|:.|:..:|:.:.:|...::.:.:.:|..::.|:..::.|..:..
Mouse    26 IIHIGAIF--DESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQ 88

  Fly   107 GVQAIFGPTDALLASHVQSICEAYDIPHI------------------EGRIDLEYNSKEFSINLY 153
            |:.|:........|..:||:.:|..|||:                  ..|.|      ::::::.
Mouse    89 GILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRND------DYTLSVR 147

  Fly   154 PSHTLLTLAYRDIMVYLNWTKVAIIYEEDY---GLFNLMHSSTETKAEMYIRQASP--------- 206
            |...|..:..|.:..|. |.|..|.|:.:|   |:...:...::...::.:::...
Mouse   148 PPVYLNEVILRVVTEYA-WQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTL 211

  Fly   207 ---------DSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETY 262
                     :.||..||        :.|:..||:..|||...:::..:.....|::....::...
Mouse   212 FDTMRIEELNRYRDTLR--------RAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDV 268

  Fly   263 DLEDFRYNSVNITAFRLVDVDSKRYLEVINQMQKLQHN-------GLDTINGS------PYIQT- 313
            |:::....|:.             .|.:|.|...:..|       |...|:.|      |:.|.
Mouse   269 DVQELVRRSIG-------------RLTIIRQTFPVPQNISQRCFRGNHRISSSLCDPKDPFAQNM 320

  Fly   314 --ESALMFDSVYAFANGLHFLNLDNHQNFYIKNLSC--TSDQTWNDGISLYNQINAAITDGLTGT 374
              .:..::|:|...||..| ..|::.:...:.:|||  .:.:.|..|.|:...|.....:||||.
Mouse   321 EISNLYIYDTVLLLANAFH-KKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTGD 384

  Fly   375 VQFVE--GRRNIFKLDILKLKQEK-----IQKVGYWHPDDGVNISDPTAFYDSNIANITLVVMTR 432
            ::|.|  |..|: ..:||.....:     ::|:|.|:|..|:|.|......::|:..:.|.|:|.
Mouse   385 LEFGENGGNPNV-HFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTV 448

  Fly   433 EERPYVMVKEDKNLTGN-LRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIP-ETNSWNGIV 495
            .|.|:|||.|  |:.|. .:::||.||:|.|::..:||.|:|.:.||:.||  .| |..:|||:|
Mouse   449 LEEPFVMVSE--NVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYG--SPQEDGTWNGLV 509

  Fly   496 QELMERRADLAVASMTINYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYV 560
            .||:.:|||:.::::||...||:|:|||..:|:..:|:|.: ...:...:|:.:.|..:.:|..:
Mouse   510 GELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR-RAEKTVDMFACLAPFDLSLWACI 573

  Fly   561 LAAYILVSFALFVMARFSPYEWKNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATS 625
            ....:||...::::      .|.|| |..:...:...  ::.||.||:.|:|::||..:.....:
Mouse   574 AGTVLLVGLLVYLL------NWLNP-PRLQMGSMTST--TLYNSMWFVYGSFVQQGGEVPYTTLA 629

  Fly   626 TRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTM------ 684
            ||::.|.|:.|.||:|||||||||||||:.|:.|.|:|..||::||:|.|||:...:..
Mouse   630 TRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMK 694

  Fly   685 ---TFFRDSKIGIYQKMWRYMENRKTAVFVKTYED--GIKRVMEGSYAFLMESTMLDYAV--QRD 742
               .|.|||   :|.:||| |.||.........|.  ||::|..|:|||:.::.:|:|..  ..|
Mouse   695 GLNPFERDS---MYSQMWR-MINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPD 755

  Fly   743 CNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKE 807
            |:...:|..:..:|||||...|||:||..|..|||||:.|.:.||..|||...|..........:
Mouse   756 CSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQCDLYSSVDAK 820

  Fly   808 SKANALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSRKNLNTENQSLCSEM-AEEL--RFAMHC 869
            .|..||.::::.|||.:|..|:.|:.::|:.|..|:.||.....::....|: .|.|  |....|
Mouse   821 QKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSRRKGSRVPSKEDDKEIDLEHLHRRVNSLC 885

  Fly   870 HGSKSRHRPRKRSC-----LNCSSVP-------------------TYVPSNVST 899
            ....|.|:....|.     |:..::|                   |::|..:.|
Mouse   886 TDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQT 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	84/429 (20%)
		ANF_receptor	61..393	CDD:279440	73/390 (19%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	141/383 (37%)
		Lig_chan	555..829	CDD:278489	101/286 (35%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		63/349 (18%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	85/432 (20%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	141/383 (37%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991		3/19 (16%)
		PDZ-binding	1005..1007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910