DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and Gria4

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus

Alignment Length:	920	Identity:	351/920 - (38%)
Similarity:	505/920 - (54%)	Gaps:	82/920 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KICCSYIILSIL----VISNALPPVIRVGAIF---TEDERESSIESAFKYAIYRINKEKTLLPNT 79
            :|.|..|:|...    :...|.|..:::|.:|   |:.|     .:||:.||:..|..    ||.
Mouse     2 RIICRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQE-----YTAFRLAIFLHNTS----PNA 57

  Fly    80 -----QLVYDIEYVPRDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGRI 139
                 .||..::.:...:||..|...|||...||.||||..|......:.|.|.|..|..|....
Mouse    58 SEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSF 122

  Fly   140 DLEYNSKEFSINLYPSHTLLTLAYRDIMVYLNWTKVAIIYEEDYGLFNLMHSSTETKAE------ 198
            ..|..| :|.:.|.||   |..|...::.:..|.....:|:.|.| ::::.:..|...:
Mouse   123 PTEGES-QFVLQLRPS---LRGALLSLLDHYEWNCFVFLYDTDRG-YSILQAIMEKAGQNGWHVS 182

  Fly   199 -MYIRQASPDSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETY 262
             :.:...:..||||:|..:.:::..|.::|.....:::....|:.:..:...|||:......:..
Mouse   183 AICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDI 247

  Fly   263 DLEDFRYNSVNITAFRLVDVDSKRYLEVINQMQKL---QHNGLDTINGSPYIQTESALMFDSVYA 324
            .||.|.:...|:|.|:|||.::....:::::.:||   ::.|.:|    |...| |||.:|.|..
Mouse   248 SLERFIHGGANVTGFQLVDFNTPMVTKLMDRWKKLDQREYPGSET----PPKYT-SALTYDGVLV 307

  Fly   325 FANGLHFLNLDNHQNFYIKNLSCTSD------QTWNDGISLYNQINAAITDGLTGTVQFVE-GRR 382
            .|.....|   ..|...|.......|      ..|..||.:...:......||||.|||.. |||
Mouse   308 MAETFRSL---RRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRR 369

  Fly   383 NIFKLDILKLKQEKIQKVGYWHP-DDGVNISD-PTAFYD-SNIANITLVVMTREERPYVMVKEDK 444
            ..:.:|:.:||....:|||||:. |..|.|.| ||...| :.|.|.|:||.|..|.||||.|::.
Mouse   370 VNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDAPTLGNDTAAIENRTVVVTTIMESPYVMYKKNH 434

  Fly   445 NL-TGNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVA 508
            .: .||.::||:|:||...||..:|.:|||.:|||..||....:|..|||:|.||:..:|::|:|
Mouse   435 EMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIA 499

  Fly   509 SMTINYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFV 573
            .:||...||.||||:||||:|||.|:.|.|......:|||::|||.|||:.::.|||.||..||:
Mouse   500 PLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL 564

  Fly   574 MARFSPYEWKNPHP-CYKE--TDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFF 635
            ::|||||||....| ..||  :|...|:|.|.||.||..|.|::||..::|::.|.|||||.|:|
Mouse   565 VSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWF 629

  Fly   636 FCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWR 700
            |.||||||||||||||||||||:||||||.|||:||||:||||:.|||..|||.|||.:|:|||.
Mouse   630 FTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWT 694

  Fly   701 YMENRKTAVFVKTYEDGIKRV--MEGSYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGIATP 762
            ||.:.:.:||.:|..:|:.||  .:|.:|||:||||.:|..|| .|:..::||.|||||||:|||
Mouse   695 YMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATP 759

  Fly   763 KGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLC 827
            |||..|..::||:|:|.|.|::..|.:|||.:.|: |...|...:.|.:||.:.|:.|||.:|:.
Mouse   760 KGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYDKGE-CGPKDSGSKDKTSALSLSNVAGVFYILVG 823

  Fly   828 GLALAVVVAIFEFCWNSR---------KNLNTENQSLCSEMAEELR-------FAMHCHGSKSRH 876
            ||.||::||:.|||:.||         |:..|.|.: .|:....|.       |..|...|:..|
Mouse   824 GLGLAMLVALIEFCYKSRAEAKRMKVAKSAQTFNPT-SSQNTHNLATYREADFFRSHKKQSQVIH 887

  Fly   877 R---PRKRSC 883
            .   .|||.|
Mouse   888 HWECGRKRPC 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	102/391 (26%)
		ANF_receptor	61..393	CDD:279440	90/353 (25%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	200/375 (53%)
		Lig_chan	555..829	CDD:278489	149/279 (53%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	103/393 (26%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	202/381 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846652
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.650