DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and GRIN3A

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	1017	Identity:	224/1017 - (22%)
Similarity:	393/1017 - (38%)	Gaps:	270/1017 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYVPRDDSFRTTKKVCSQLEAGV 108
            |..|::..|        |..:|:..:|:.:.|||                :..:.:|...:|||:
Human   118 RAEALWPRD--------ALLFAVDNLNRVEGLLP----------------YNLSLEVVMAIEAGL 158

  Fly   109 --------QAIFGPTDALLASHVQSICEAYDI---------PHIEGR-IDLEYNSKEFSINLY-- 153
                    .:...|..:...|.:||:|....:         |..:|. ::|:..|....|.:.
Human   159 GDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISI 223

  Fly   154 -----------PSHTLLTL-----AYRDIMVYL----NWTKVAIIY-EEDYGLFNLMHSSTETKA 197
                       |.|..|:|     :..|:.|.:    ||...:::. :||:.:.:.
Human   224 VRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDF--------- 279

  Fly   198 EMYIRQASPDSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETY 262
                                      :::..|.|  |....||:.:..|      :.:|.||.::
Human   280 --------------------------LLLTQNNS--KFHLGSIINITAN------LPSTQDLLSF 310

  Fly   263 ---DLEDFRYNSVNITAFRLVDVDS-KRYLEVINQ-----------------MQKLQHNGLD--- 303
               .||..:.::..:..|. .|::| :|..|:..|                 :::|:..||.
Human   311 LQIQLESIKNSTPTVVMFG-CDMESIRRIFEITTQFGVMPPELRWVLGDSQNVEELRTEGLPLGL 374

  Fly   304 TINGSP-------YIQTESALMFDSVYAFANGLHFLNLDNHQNFYI-KNLSCTSDQTWN--DGIS 358
            ..:|..       |:|       |::...|..:....:...:...| ..::|...:|.|  .|..
Human   375 IAHGKTTQSVFEHYVQ-------DAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQY 432

  Fly   359 LYNQINAAITDGLTGTVQ-----FVEGRRNIFKLDILKLKQEKIQK-----VGYWHPDDGVNISD 413
            |...:......||:|:::     .|....|.|   |..|:.:.:.|     :|.|  ..|..:.|
Human   433 LSRFLANTTFRGLSGSIRVKGSTIVSSENNFF---IWNLQHDPMGKPMWTRLGSW--QGGKIVMD 492

  Fly   414 -----------PTAFYDSNIANITLVVMTREERPYVMVKE------------------------- 442
                       .|.|  .:.:.:.|.|:|..|.|:|..:|
Human   493 YGIWPEQAQRHKTHF--QHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLD 555

  Fly   443 -------DKNLTGNLRFE----GFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQ 496
                   ..|.|..::|:    |:|||||:.||..:.|.:.:.:|.|..||.:  :...|.|:|.
Human   556 SLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAW--KNGHWTGLVG 618

  Fly   497 ELMERRADLAVASMTINYARESVIDFTKPFMNLGIGILFKV-PTSQPTRLFSFMNPLAIEIWLYV 560
            :|:...|.:||.|.:||.||..|||||.||.:..:|||.:. .|:.|  :.:||.||...:||.:
Human   619 DLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAP--IGAFMWPLHWTMWLGI 681

  Fly   561 LAAYILVSFALFVMARF-SPYEWKNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLN-PKA 623
            ..       ||.:.|.| :.||||:|.....:.......||.|::..........:...:. ||.
Human   682 FV-------ALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKC 739

  Fly   624 TSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESASD--LAEQTE-ISYGTLEGGSTMT 685
            .:.|.:...|..||:..:|:|||||||.:..|::...:....|  |...:: ..:||:...|...
Human   740 WTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAED 804

  Fly   686 FFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGI---KRVMEGSYAFLMESTMLDY--AVQRDCNL 745
            :.|.|...:::.|.||.        |....||:   |...|...||:|:..:|||  ::..||.|
Human   805 YVRQSFPEMHEYMRRYN--------VPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKL 861

  Fly   746 TQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKA 810
            ..:|.....:||||..|..||....||..|.:.:..|.:.:|:|||::..  .|.:...: .::.
Human   862 LTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVV--PCGKRSFA-VTET 923

  Fly   811 NALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSRKNLNTENQSLCSEMAEELRFAMH----CHG 871
            ..:|:::..|:||:|..|..|:::..|.|...........:|:|       :|::.:|    .|.
Human   924 LQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKS-------KLQYWLHTSQRLHR 981

  Fly   872 S--------KSRH----RPRKRSCLNCSSVPTYVPSNVSTSN 901
            :        |.:|    |..|||.:....:..:..||:|..|
Human   982 AINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDN 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	76/450 (17%)
		ANF_receptor	61..393	CDD:279440	68/411 (17%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	120/415 (29%)
		Lig_chan	555..829	CDD:278489	75/283 (27%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	77/458 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118		224/1017 (22%)
		ANF_receptor	127..469	CDD:279440	68/411 (17%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	119/414 (29%)
		Lig_chan	676..942	CDD:278489	75/283 (27%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		6/42 (14%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156098
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740