DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and grik3

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	XP_031752773.1	Gene:	grik3 / 100498426	XenbaseID:	XB-GENE-6050069	Length:	919	Species:	Xenopus tropicalis

Alignment Length:	899	Identity:	398/899 - (44%)
Similarity:	556/899 - (61%)	Gaps:	68/899 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LPPVIRVGAIFTEDERE-----SSIESAFKYAIYRINKEKTLLPNTQLVYDIEYVPRDDSFRTTK 98
            :|.|||:|.||...|..     |:.|.||:::...||:.:||||||.|.|||:.:...|||...:
Frog    32 MPHVIRIGGIFEHLEGPTGQLVSAEEQAFRFSASIINRNRTLLPNTTLTYDIQRINLYDSFEANR 96

  Fly    99 KVCSQLEAGVQAIFGPTDALLASHVQSICEAYDIPHIEGR-----IDLEYNSKEFSINLYPSHTL 158
            |.|.||..||.|||||:.:..::.|||||.|.::|||:.|     :|   |...|.:||||.:..
Frog    97 KACDQLALGVVAIFGPSHSSSSNAVQSICNALEVPHIQVRWKHHPLD---NRDSFYVNLYPDYAS 158

  Fly   159 LTLAYRDIMVYLNWTKVAIIYEEDYGLFNLMH---SSTETKAEMYIRQASPDS--YRQVLRAIRQ 218
            |:.|..|::.:|.|....::|::..||..|..   :.......:.|||..|:|  .|.:|:.:::
Frog   159 LSHAILDLVQFLKWRSATVVYDDSTGLIRLQELIMAPARYNIRLKIRQLPPESEDARPLLKEMKR 223

  Fly   219 KEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFRYNSVNITAFRLVDVD 283
            ...::||.|.:.:......|..:.:.|....|||:|||.||...|||.:||:.||:|.||:::||
Frog   224 GREFRIIFDCSHTMAAQILRQAMAMGMMTEYYHYIFTTLDLYALDLEPYRYSGVNLTGFRILNVD 288

  Fly   284 SKRYLEVINQMQKLQHNG--------LDTINGSPYIQTESALMFDSVYAFANGLHFLNL--DNHQ 338
            :.....::::....:|..        ||.|     :.|::||.:|:|       |.:::  ....
Frog   289 NPYVSSIVDKWSMERHQATPKPESGLLDGI-----MTTDAALTYDAV-------HIVSVCYQRAP 341

  Fly   339 NFYIKNLSCTSDQTWNDGISLYNQINAAITDGLTGTVQF--VEGRRNIFKLDILKLKQEKIQKVG 401
            ...:.:|.|...:.|..|....|.|..|..:||||.:.|  ..|.|..|.|||:.||::.::|||
Frog   342 QMTVNSLQCHRHKAWRFGSRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVG 406

  Fly   402 YWHPDDGVNISDPTAFYDSNIA----NITLVVMTREERPYVMVK-EDKNLTGNLRFEGFCIDLLK 461
            .|:|.||:||::.......||:    |.||:|.|..|.||||.| .|..|.|..|||||||||||
Frog   407 TWNPSDGLNITETARGRGPNISESLTNRTLIVTTVLEEPYVMFKRSDTPLFGKDRFEGFCIDLLK 471

  Fly   462 AIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVIDFTKPF 526
            .||..:||.|.|.||.|..||.. .|...|||:|:||::.:||||||.:||.:.||.||||:|||
Frog   472 KIAEILGFDYDIRLVEDAKYGSQ-DEKGQWNGLVKELIDHKADLAVAPLTITHVREKVIDFSKPF 535

  Fly   527 MNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARFSPYEWKNPHPCYKE 591
            |.|||.||::........:|||:|||:.:||:|:|.||:.||..|||:||||||||.:.|||...
Frog   536 MTLGISILYRKANGTAPSVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYDAHPCNPG 600

  Fly   592 TDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVER 656
            ||:|||.|::.|||||..|..::|||.|.|||.||||:||.|:||.|||||||||||||||||||
Frog   601 TDVVENNFTLLNSFWFAVGALMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVER 665

  Fly   657 MISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGIKRV 721
            |.|.|:||.|||:||:|.||.:..|:||.||:.|.|..::|||.:|.:|.:|: ||:.|:||:||
Frog   666 MESAIDSADDLAKQTKIEYGAVVDGATMNFFKKSHISTFEKMWAFMSSRPSAL-VKSNEEGIQRV 729

  Fly   722 MEGSYAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQI 786
            :...||.|||||.::|..||:|||||||||:|||||||.||.|||:||:||:|||:|||...|..
Frog   730 LSADYALLMESTAIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDRISIAILQLQEADEIHK 794

  Fly   787 LYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSRKNLNTE 851
            :.::||::.|  | .::|:||  |:|||::|:||:|:||..||.|:||||:.||.:..||....|
Frog   795 MKERWWRSGG--C-PEEKNKE--ASALGIQNMGGIFIVLAGGLILSVVVAMAEFVYKLRKTAERE 854

  Fly   852 NQSLCSEMAEELRFAMHCHGSKSRHRPRKRSCLNCSSVPTYVPS----NVSTSN 901
            .:|.||.||:|:|.::.|. .:.:|:|:.         |..|.|    |:.|.|
Frog   855 QRSFCSTMADEIRLSLTCQ-RRVKHKPQP---------PVMVKSDAVINMHTFN 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	130/392 (33%)
		ANF_receptor	61..393	CDD:279440	114/353 (32%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	217/369 (59%)
		Lig_chan	555..829	CDD:278489	161/273 (59%)
grik3	XP_031752773.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	361	1.000	Domainoid score	I951
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.030