DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and grin3b

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	XP_017952374.2	Gene:	grin3b / 100497172	XenbaseID:	XB-GENE-990106	Length:	1005	Species:	Xenopus tropicalis

Alignment Length:	942	Identity:	214/942 - (22%)
Similarity:	365/942 - (38%)	Gaps:	186/942 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYVPRDDS-FRTTKKVCSQLEA 106
            :|:||:...   ....::..:..:.||::...|..|..|.. :...|||.| ...|:.:|..|.|
Frog    37 VRLGALLPS---YGHTQARIQNVLSRISRTSWLPYNLSLEV-VSGAPRDRSPASLTRWLCQVLVA 97

  Fly   107 -GVQAIFGPTDA--------LLASHVQ----SICEAYDIPHIEGRIDLEYNSKEFSINLYPSHTL 158
             |:.|:.....|        .|:|.::    ||.|...|..:..:     |.....::...|...
Frog    98 QGIAAVLAFPQAQEELLQLEFLSSFLEIPFISILEQEQIVPLATK-----NPFHLQMDTQSSVEN 157

  Fly   159 LTLAYRDIMVYLNWTKVAII--YEEDYGLFNLMHSSTETKAEMYIRQASP-------DSYRQVLR 214
            |...:..::...:|.:|.||  :..|........:|..|.....|....|       ...:|...
Frog   158 LMDIFFSVLQNSSWEEVDIITCHPWDSASIQRYLTSNTTLVSRTILNIHPVDESALVPFLQQHFE 222

  Fly   215 AIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYM---------FTT----------FDLE 260
            :::..:...::...:.......||......:..|.:|:|         .||          .::.
Frog   223 SMKNPQFPMLLYGCDARRSSLVFRVARDCGLEAHEFHWMIGHPLNGEEMTTEGMPPGLLAYGEVS 287

  Fly   261 TYDLEDFRYNSVNITAFRLVD--VDSKRYLEVI------NQMQKLQHNGLDTINGSPYIQTESAL 317
            ...:|.|..::|.:.. |.:.  |..:..|.:|      |..|..|:....:........|..:.
Frog   288 RPTMEKFIRDAVGLVT-RAISAAVHVRPDLALIQSMVNCNDKQTKQNESSGSYLSRFLANTSFSG 351

  Fly   318 MFDSVYAFANGLHFLNLDNHQNFYIKNLSCTSDQTWNDGISLYNQINAAITDG--LTGTVQFVEG 380
            ....:|...|.:|   .::|...:........|.||             :|.|  ..|.::..||
Frog   352 QTGQIYVSNNLIH---TEHHYRIWSLVRDSLGDPTW-------------VTVGGWRQGKMEVEEG 400

  Fly   381 RRNIFKLDILKLKQEKIQKVGYWHPDDGVNISDPTAFYDSNIANITLVVMTREERPYVMVKE--- 442
                       |.|.:||:   |.|..|            ..|...|.|:|..|.|:|..:|
Frog   401 -----------LWQSRIQQ---WEPAPG------------GFARTKLRVVTLVEHPFVFTREVDA 439

  Fly   443 ---------------DKNLTGNLRFE------------------GFCIDLLKAIATQVGFQYKIE 474
                           :.:...::.||                  |:|||||:.::..:.|.:::.
Frog   440 DGSCPAGQMCLDPRTNNSAVLDVLFEELNSPNGSVPLEYKTCCYGYCIDLLEKLSEDLRFDFELY 504

  Fly   475 LVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTINYARESVIDFTKPFMNLGIGILFKV-P 538
            :|.|..||.  .:.:.|.|:|.:|:...|.:||.|.:||.||.:|||||.||.:..:|||.:: .
Frog   505 IVGDGKYGA--RKGDRWTGLVGDLLSGAAHMAVTSFSINSARSTVIDFTSPFYSTSLGILVRMRD 567

  Fly   539 TSQPTRLFSFMNPLAIEIWLYV-LAAYILVSFALFVMARFSPYEWKNPH---PCYKETDIVENQF 599
            |:.|  :.:||.||...:|:.: :|.:|...|..|       ||||:|.   |..:....:.:..
Frog   568 TASP--IGAFMWPLHWSMWVGIFVALHITALFLTF-------YEWKSPFGMTPHGRNRTKIFSYS 623

  Fly   600 SISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIISSYTANLAAFLTVERMISPIESA 664
            |..|..:.|  .|.|..|...||..:.|::...|..|||:::|||||||||.:..::....:...
Frog   624 SALNLCYAI--LFGRTVSSKTPKCCTGRVLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEALSGI 686

  Fly   665 SD--LAEQTE-ISYGTLEGGSTMTFFRDSKIGIYQKMWRYMENRKTAVFVKTYEDGI---KRVME 723
            .|  |...:: ..:||:...|...:.:.|    :.:|..||  ||.:  |....||:   |....
Frog   687 HDPKLHHPSQGFRFGTVWESSAEQYIKKS----FPEMHNYM--RKFS--VPATSDGVHLLKTDPP 743

  Fly   724 GSYAFLMESTMLDY--AVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGIIQI 786
            ...||:|:..:|||  ::..||.|..||.....:||||..|:.||....||..|...:..|.:..
Frog   744 TLNAFIMDKALLDYEVSIDSDCKLLTIGKPFAIEGYGIGLPQNSPLTSNISEFISRYKSSGFMDT 808

  Fly   787 LYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCGLALAVVVAIFEFCWNSRKNLNTE 851
            |:|||:|..  .|.:...: .::...:|:.:..|:||:|..|...:::.::.|         ...
Frog   809 LHDKWYKMV--PCGKRVYA-VTETLQMGIYHFSGLFVLLCIGFCGSLLTSLME---------RVV 861

  Fly   852 NQSLCSEMAEELRFAMHCHGSKSRHRPRKRSC 883
            ...:...:....||....|.|:..||....:|
Frog   862 YHLILPRIRRRRRFKYWLHTSQKIHRALNMTC 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	75/417 (18%)
		ANF_receptor	61..393	CDD:279440	65/383 (17%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	122/417 (29%)
		Lig_chan	555..829	CDD:278489	81/285 (28%)
grin3b	XP_017952374.2	PBP1_iGluR_NMDA_NR3	29..402	CDD:380600	68/401 (17%)
		PBP2_iGluR_NMDA_Nr3	418..814	CDD:270438	121/416 (29%)
		Lig_chan	582..848	CDD:395014	81/285 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910