DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and gria3

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_001106494.1	Gene:	gria3 / 100127683	XenbaseID:	XB-GENE-1010483	Length:	887	Species:	Xenopus tropicalis

Alignment Length:	930	Identity:	333/930 - (35%)
Similarity:	496/930 - (53%)	Gaps:	110/930 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IILSILVIS-NALPPVIRVGAIFTEDERESSIESAFKYAI--YRINKEKTLLPNTQLVYDIEYVP 89
            ::||::..| ...|..|.:|.:|..:..:.  .|||.:|:  :..|:..|..| .||.:.::::.
Frog    12 LLLSLVGESCGGFPNTINIGGLFMRNTIQE--HSAFLFAVQLHNTNQNNTERP-FQLFHHVDHLD 73

  Fly    90 RDDSFRTTKKVCSQLEAGVQAIFGPTDALLASHVQSICEA----YDIPHIEGRIDLEYNSKEFSI 150
            ..:||..|...|||...||.||||..|.:..:.:.|.|.|    :..|......|:     :|.|
Frog    74 SSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFITPSFPTDADV-----QFVI 133

  Fly   151 NLYP--SHTLLTLAYRDIMVYLN---WTKVAIIYEEDYG---LFNLMHSSTETKAEMYIRQA--- 204
            .:.|  ...:|||        ||   |.|...:|:.:.|   |..:|.::.:...::..|..
Frog   134 QMRPPLKGAILTL--------LNEYDWQKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNI 190

  Fly   205 -SPDSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDLEDFR 268
             ....:::::..:.:::..:.::|.....|.:....::.|..:...||||........:.||...
Frog   191 KDVQEFKRIIEEMDRRQEKRFVIDCEVERINTILEQVVILGKHTRGYHYMLANLGFTGFTLERVM 255

  Fly   269 YNSVNITAFRLVDVDSKRYLEVINQMQKLQHNGLDTINGSPYIQTESALMFDSVYAFANGLHFLN 333
            :...|:|.|::|:.::....:.:.:..:|..........:| ::..|||..|:|...|....:|
Frog   256 HGGANVTGFQIVNNENPIVQQFLQRWVRLDEREFPEARNTP-LKYTSALTHDAVLVIAEAFRYL- 318

  Fly   334 LDNHQNFYIKNLSCTSD------QTWNDGISLYNQINAAITDGLTGTVQF-VEGRRNIFKLDILK 391
              ..|...:.......|      ..|:.||.:...:......|:||.:|| ..|||..:.:|:.:
Frog   319 --RRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYE 381

  Fly   392 LKQEKIQKVGYWH--------PDDGVNISDPTAFYDSNIANITLVVMTREERPYVMVKEDKN-LT 447
            :...|.:|||:|:        ||     ..||. ..|::.|.|::|.|..|.||||.|::.. |.
Frog   382 MTATKPRKVGHWNEYERFVPAPD-----QQPTN-ESSSVENKTIIVTTILENPYVMKKKNHELLD 440

  Fly   448 GNLRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTI 512
            ||.::||:|:||...||..||.:||:.:|.|..||...|||..|||:|.||:..|||:|||.:||
Frog   441 GNDKYEGYCVDLASEIAKHVGIKYKLSIVEDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 505

  Fly   513 NYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARF 577
            ...||.||||:||||:|||.|:.|.|......:|||::|||.|||:.::.|||.||..||:::||
Frog   506 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRF 570

  Fly   578 SPYEWKNPHPCYKETDIVE---------NQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCW 633
            |||||.     .::||...         |:|.|.||.||..|.|::||..::|::.|.|||||.|
Frog   571 SPYEWH-----LEDTDEARDPQNPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVW 630

  Fly   634 FFFCLIIISSYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKM 698
            :||.||||||||||||||||||||:||||||.|||:||||:||||:.|||..|||.|||.:|:||
Frog   631 WFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKM 695

  Fly   699 WRYMENRKTAVFVKTYEDGIKRV--MEGSYAFLMESTMLDYAVQR-DCNLTQIGGLLDSKGYGIA 760
            |.||::.:.:||.||.:||:.||  .:|.:|||:||||.:|..|| .|:..::||.|||||||:|
Frog   696 WSYMKSAEPSVFTKTTDDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVA 760

  Fly   761 TPKGSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVL 825
            |||||.....::||:|:|.|:||:..|.:|||.:.|: |...|...:.|.:||.:.|:.|||.:|
Frog   761 TPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGE-CGAKDSGSKDKTSALSLSNVAGVFYIL 824

  Fly   826 LCGLALAVVVAIFEFCWNSRKNLNTENQSLCSEMAEELRFAMHCHGSKSRHRPRKRSCLNCSSVP 890
            :.||.||::||:.|||:.||              ||..|  |....:....:|
Frog   825 VGGLGLAMMVALIEFCYKSR--------------AESKR--MKLTKNAQNFKP------------ 861

  Fly   891 TYVPSNVSTSNVGVYYNYFN 910
               |...||.|...|...:|
Frog   862 ---PPAASTQNYATYREGYN 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	87/398 (22%)
		ANF_receptor	61..393	CDD:279440	77/356 (22%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	204/381 (54%)
		Lig_chan	555..829	CDD:278489	149/285 (52%)
gria3	NP_001106494.1	Periplasmic_Binding_Protein_Type_1	29..400	CDD:324556	85/390 (22%)
gria3	NP_001106494.1	PBP2_iGluR_AMPA	416..798	CDD:270433	206/387 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000