DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11155 and grid1

DIOPT Version :9

Sequence 1:	NP_651941.2	Gene:	CG11155 / 43822	FlyBaseID:	FBgn0039927	Length:	910	Species:	Drosophila melanogaster
Sequence 2:	NP_001096470.1	Gene:	grid1 / 100125089	XenbaseID:	XB-GENE-990290	Length:	1009	Species:	Xenopus tropicalis

Alignment Length:	941	Identity:	253/941 - (26%)
Similarity:	450/941 - (47%)	Gaps:	107/941 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VIRVGAIFTEDERESSIESAFKYAIYRINKEKTLLPNTQLVYDIEYVPRDDSFRTTKKVCSQLEA 106
            :|.:||||.|:..:.  :..|:.|:..::....:|.:.::.|.|:::..::.|:..::.|..:..
Frog    23 IIHIGAIFEENAVKD--DEVFQLAVSDLSLNDDILQSEKITYSIKFIEANNPFQAVQEACDLMTQ 85

  Fly   107 GVQAIFGPTDALLASHVQSICEAYDIPHI--------EGRIDLEYN----SKEFSINLYPSHTLL 159
            |:.|:...|....|:.:||:.:|..||||        ..|...::|    .:|:::...|...|
Frog    86 GILALVTSTGCASANALQSLTDAMHIPHIFVQRNSGGSPRTVCQFNPSPEGEEYTLAARPPVRL- 149

  Fly   160 TLAYRDIMV----YLNWTKVAIIYEEDY---GLFNLMHSSTETKAEMYIRQASP----------- 206
                .|:|:    .|.|.|..:.|:.||   ||...:..::....::.:::...
Frog   150 ----NDVMLKLVTELRWQKFIVFYDSDYDIRGLQGFLDQASRLGLDVSLQKVDRNISRVFATLFT 210

  Fly   207 -------DSYRQVLRAIRQKEIYKIIVDTNPSHIKSFFRSILQLQMNDHRYHYMFTTFDLETYDL 264
                   :.||..||        :.|:..:|...:||....::..:.....|:::...::...::
Frog   211 SMKTEELNRYRDTLR--------RAILLLSPRGAQSFISEAVETNLASKDSHWVYVNEEINDAEI 267

  Fly   265 EDFRYNSV-NITAFRLVDVDSK-RYLEVINQMQKLQHNGLDTING-SPYIQTESALMFDSVYAFA 326
            .:..:::: .||..|.:....| ..:..:....::.....|...| ...:|..:..::|||...|
Frog   268 VELVHSALGRITVIRQIFPSLKDNNIRCVRNNHRIASLPCDPQEGYLQMLQVSNLYLYDSVLMLA 332

  Fly   327 NGLHFLNLDNHQNFYIKNLSC--TSDQTWNDGISLYNQINAAITDGLTGTVQFVE-GRRNIFKLD 388
            |..| ..|::.:...:.:|:|  .|.:.||.|.|:.:.|......||||.::|.| |.....:.:
Frog   333 NAFH-RKLEDRKWHSMASLNCMRKSTKPWNGGRSMLDTIKKGRITGLTGIMEFKEAGANPHVQFE 396

  Fly   389 ILKLKQEK-----IQKVGYWHPDDGVNISDPTAFYDSNIANITLVVMTREERPYVMVKEDKNLTG 448
            ||.....:     ::::..|....|.|.|......::::..:||.|:|..|.|:|||.|  |:.|
Frog   397 ILGTSYSETFGKDVRRLATWDSMKGFNGSLQEKPLNNDLQGLTLKVVTVLEEPFVMVAE--NILG 459

  Fly   449 N-LRFEGFCIDLLKAIATQVGFQYKIELVPDNMYGVYIPETNSWNGIVQELMERRADLAVASMTI 512
            . .|::||.|::|..::.::||:|:|...||..||..: ...||||::.||:.:|||:|::::||
Frog   460 QPKRYKGFSIEILDELSNRLGFKYEIYQAPDGKYGHQL-SNGSWNGMIGELINKRADIAISAITI 523

  Fly   513 NYARESVIDFTKPFMNLGIGILFKVPTSQPTRLFSFMNPLAIEIWLYVLAAYILVSFALFVMARF 577
            ...||:|:||||.:::..:|||.|.| .:...:||...|....:|..:.|...:|...:||:.|.
Frog   524 TPERENVVDFTKRYLDYSVGILIKKP-EERINIFSLFAPFDFAVWACIAAVIPVVGVLIFVLNRI 587

  Fly   578 SPYEWKNPHPCYKETDIVENQFSISNSFWFITGTFLRQGSGLNPKATSTRIVGGCWFFFCLIIIS 642
            .....:|.....:.|     ..::.::.|.:.|.|::||......:.:.|||.|.|:.|.||:.|
Frog   588 QAVRAQNSSQTSQST-----SSTLHSAIWIVYGAFVQQGGESAANSVAMRIVMGSWWLFTLIVCS 647

  Fly   643 SYTANLAAFLTVERMISPIESASDLAEQTEISYGTLEGGSTMTFFRDSKIG------IYQKMWRY 701
            ||||||||||||.||.:||.:..|||:|.::.|||::..|...:|:.....      .:.::||.
Frog   648 SYTANLAAFLTVSRMDNPIRTFQDLAKQVDLPYGTVKDSSVYEYFKSKGTNTLVQDRTFAELWRT 712

  Fly   702 M-ENRKTAVFVKTYEDGIKRVMEGSYAFLMESTMLDYAVQRD--CNLTQIGGLLDSKGYGIATPK 763
            : :|..:...|.:..:||::...|:||||.:.|:::||...|  |::...|..:.|||||||...
Frog   713 IGKNNGSDNCVSSPSEGIRKAKRGNYAFLWDVTVVEYAALTDDECSVAVTGNTISSKGYGIALQH 777

  Fly   764 GSPWRDKISLAILELQEKGIIQILYDKWWKNTGDVCNRDDKSKESKANALGVENIGGVFVVLLCG 828
            |||:||..|..|||.|:.|.:.:|.:|||..||........:.::...||.:.:..|||.:|..|
Frog   778 GSPYRDIFSQRILEFQDSGRLDVLKEKWWPRTGRCDLNSHNNAQNDGKALKLHSFAGVFCILAIG 842

  Fly   829 LALAVVVAIFEFCWNSRK------------NLNTENQSLCSEMAEELRF-----------AMHCH 870
            |.||.:||..|..|||.:            ||...::.|.|.:.|::..           |:...
Frog   843 LLLACLVAALELWWNSNRCRQDSPKEDKEVNLEQVHRRLNSLIDEDMAHKQISTASIEISALEIG 907

  Fly   871 GSKSRH-RPRKRSCLNCSSVPTYVPSNVSTS 900
            |..|:. .|.:.......||.|::|.....|
Frog   908 GMPSQTLEPLREYQSTQLSVTTFLPEQTGHS 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11155	NP_651941.2	PBP1_iGluR_Kainate	44..410	CDD:107377	80/413 (19%)
		ANF_receptor	61..393	CDD:279440	73/374 (20%)
		PBP2_iGluR_Kainate	424..793	CDD:270432	137/378 (36%)
		Lig_chan	555..829	CDD:278489	94/282 (33%)
grid1	NP_001096470.1	PBP1_iGluR_delta_1	25..424	CDD:107387	80/414 (19%)
		ANF_receptor	39..400	CDD:279440	73/374 (20%)
		PBP2_iGluR_delta_1	437..807	CDD:270448	137/378 (36%)
		Lig_chan	565..842	CDD:278489	94/281 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100