Protein Alignment Kif3C and KIF14

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_055690.1
• Gene: KIF14 / 9928
• HGNCID: 19181
• Length: 1648
• Species: Homo sapiens
• Alignment Length: 770
• Identity: 204/770 - (26%)
• Similarity: 326/770 - (42%)
• Gaps: 196/770 - (25%)

  Fly     2 SENIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFI-------FDSVYNMKT 59
            :..:.|.||.||..:.||......:|.::...::|.:|..:  |...||       ||..:....
Human   356 NSQVTVAVRVRPFTKREKIEKASQVVFMSGKEITVEHPDTK--QVYNFIYDVSFWSFDECHPHYA 418

  Fly    60 DTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERIS- 123
            ....:|:::...|:|...||:|..:|||||||.||::||.|   ||...||||:..:.:|.:::
Human   419 SQTTVYEKLAAPLLERAFEGFNTCLFAYGQTGSGKSYTMMG---FSEEPGIIPRFCEDLFSQVAR 480

  Fly   124 -MTTNVRYLALVTYLEIYNERIRDLL-NKNENTNVINHF-LKELPGIGVSVPTLTTQPVVNANQC 185
             .|..|.|...:::.|:|||:|.||| .|:||....... ::|.|..|..|..|:...|.:....
Human   481 KQTQEVSYHIEMSFFEVYNEKIHDLLVCKDENGQRKQPLRVREHPVYGPYVEALSMNIVSSYADI 545

  Fly   186 YDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSER 250
            ..||..|||.|.||||.||..|||||::||:.:.|:. ...:..:........:::|:|||||||
Human   546 QSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTK-TEFVEGEEHDHRITSRINLIDLAGSER 609

  Fly   251 QRKTGAQGDRLKEASQINLSLSALGNVISSL---VDGKAKHVPFRDSKLTRLLQDSLGGNTKTLM 312
            .......||||||...||.||..||.|||:|   .:.::..:|:|:|.||.||::|||||:||.|
Human   610 CSTAHTNGDRLKEGVSINKSLLTLGKVISALSEQANQRSVFIPYRESVLTWLLKESLGGNSKTAM 674

  Fly   313 ISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYL------------- 364
            |:.|||...:.:||:||||||::|:.|.|..|:|||.....:|:.:.||..|
Human   675 IATISPAASNIEETLSTLRYANQARLIVNIAKVNEDMNAKLIRELKAEIAKLKAAQRNSRNIDPE 739

  Fly   365 --------------------------------------KRMLQESQQ----------------II 375
                                                  ||.|||:::                ::
Human   740 RYRLCRQEITSLRMKLHQQERDMAEMQRVWKEKFEQAEKRKLQETKELQKAGIMFQMDNHLPNLV 804

  Fly   376 NKNNDPN------KIIKSPLKIIQHTNMNSTKNVQ---------------------IIDLGR--- 410
            |.|.||.      .:||.....:.....||:.::|                     ||.:|.
Human   805 NLNEDPQLSEMLLYMIKEGTTTVGKYKPNSSHDIQLSGVLIADDHCTIKNFGGTVSIIPVGEAKT 869

  Fly   411 --NCK-------------------ASFKTNNSILTKP-------NFPLIQSKEEVQLQARSRIDL 447
              |.|                   ..|:.|:.:..:.       :.|:.:..::.:. |::.:.:
Human   870 YVNGKHILEITVLRHGDRVILGGDHYFRFNHPVEVQKGKRPSGRDTPISEGPKDFEF-AKNELLM 933

  Fly   448 IKRSLIGGERIHDFELKEK-------HMARKYAAQRHLSAIAIALSRVKCEDRDLLQGHYATITQ 505
            .:||.:..| |.:.:||.|       .:|::.|.|...|..|...|::|..:.:|.:.......|
Human   934 AQRSQLEAE-IKEAQLKAKEEMMQGIQIAKEMAQQELSSQKAAYESKIKALEAELREESQRKKMQ 997

  Fly   506 EIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDR--------------EDYL-----------DE 545
            ||:     .:|...||:.||.....|..|..:::              ||:.           .|
Human   998 EIN-----NQKANHKIEELEKAKQHLEQEIYVNKKRLEMETLATKQALEDHSIRHARILEALETE 1057

  Fly   546 IRNLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSLWNDDLKMWRIPESDLI 600
            .:.:.::|:..||       |....|:.:|..|     .|:.......|.|::.|
Human  1058 KQKIAKEVQILQQ-------NRNNRDKTFTVQT-----TWSSMKLSMMIQEANAI 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	132/349 (38%)
KIF14	NP_055690.1	Required for PRC1-binding	1..356		204/770 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		Required for microtubule-binding with high affinity. /evidence=ECO:0000250|UniProtKB:L0N7N1	356..737		142/386 (37%)
		KISc_KIF1A_KIF1B	357..708	CDD:276816	135/356 (38%)
		Kinesin_assoc	705..823	CDD:465047	19/117 (16%)
		FHA_KIF14	794..901	CDD:438759	16/106 (15%)
		Required for CIT-binding	901..1648		41/219 (19%)
		Smc	<927..>1077	CDD:440809	33/162 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1600..1648