Protein Alignment Kif3C and CIN8

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_010853.2
• Gene: CIN8 / 856648
• SGDID: S000000787
• Length: 1000
• Species: Saccharomyces cerevisiae
• Alignment Length: 785
• Identity: 216/785 - (27%)
• Similarity: 326/785 - (41%)
• Gaps: 248/785 - (31%)

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEIN--------EFAVSVTNPSARISQQ--KKFIFDSVYNMK 58
            ||.|.||||..|  |:|.:.::.|.:|        |.:::.|..:...:|.  |::..|.|:...
Yeast    36 NITVAVRCRGRN--EREISMKSSVVVNVPDITGSKEISINTTGDTGITAQMNAKRYTVDKVFGPG 98

  Fly    59 TDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDE-----NFSNSTGIIPKCFDHI 118
            ...::|:||:...|.:..|:|||.|:..||.|..|||:||.|||     ..|::.||||:....:
Yeast    99 ASQDLIFDEVAGPLFQDFIKGYNCTVLVYGMTSTGKTYTMTGDEKLYNGELSDAAGIIPRVLLKL 163

  Fly   119 FERISMTTNVRYLALVTYLEIYNERIRDLLNKN----ENTNVINHFLKE---------------- 163
            |:.:.:..| .|:...:::|:|||.::|||:.|    .||.....|:|:
Yeast   164 FDTLELQQN-DYVVKCSFIELYNEELKDLLDSNSNGSSNTGFDGQFMKKLRIFDSSTANNTTSNS 227

  Fly   164 ----------------------------------LPGI--------------------------- 167
                                              ||..
Yeast   228 ASSSRSNSRNSSPRSLNDLTPKAALLRKRLRTKSLPNTIKQQYQQQQAVNSRNNSSSNSGSTTNN 292

  Fly   168 ----------------------GVSVPTLTTQPVVNANQCYDWLHFGNKNRVTAATLMNKNSSRS 210
                                  |:.:..|....:.||.:..:.|..|.|:|..|:|.||..||||
Yeast   293 ASSNTNTNNGQRSSMAPNDQTNGIYIQNLQEFHITNAMEGLNLLQKGLKHRQVASTKMNDFSSRS 357

  Fly   211 HTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALG 275
            ||||||||.:.      ..|....|  .|::||||||||...::||...|.|||..||.||..||
Yeast   358 HTIFTITLYKK------HQDELFRI--SKMNLVDLAGSENINRSGALNQRAKEAGSINQSLLTLG 414

  Fly   276 NVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNIS 340
            .||::||| |:.|:|||:|||||||||||||||||.:|:.|||..:..:||.|||.|||:||||.
Yeast   415 RVINALVD-KSGHIPFRESKLTRLLQDSLGGNTKTALIATISPAKVTSEETCSTLEYASKAKNIK 478

  Fly   341 NKPKINE-DPKDARLRQYQNEILYLKRML--QESQQIINKNNDPNKIIKSPLKIIQHTNMNSTKN 402
            |||::.. ..||..::....|:..:|..|  .:|::.|..:.|..|.:.|.|:        |.||
Yeast   479 NKPQLGSFIMKDILVKNITMELAKIKSDLLSTKSKEGIYMSQDHYKNLNSDLE--------SYKN 535

  Fly   403 -VQIIDLGRNCK---ASFKTNNSILTKPNFPLIQSKEEVQLQARSRIDLIKRSLIGGERIHDFEL 463
             ||      .||   .|..:.|::|.|..   ::|||.:|.| ..:|:.:|.::
Yeast   536 EVQ------ECKREIESLTSKNALLVKDK---LKSKETIQSQ-NCQIESLKTTI----------- 579

  Fly   464 KEKHMARKYAAQRHLSAIAIALSRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEV 528
                                                            |::|...:|....|:|:
Yeast   580 ------------------------------------------------DHLRAQLDKQHKTEIEI 596

  Fly   529 SDLNSE-------FQLDREDYLDEIRNLGRQVKFH---------QQLFLKFSSNPGKFDRNWTPD 577
            ||.|::       .|:...||.....:|.::.:.|         ..|||:.::        ...:
Yeast   597 SDFNNKLQKLTEVMQMALHDYKKRELDLNQKFEMHITKEIKKLKSTLFLQLNT--------MQQE 653

  Fly   578 TILQNSLWNDDLKMWRIPESDLIKLPPATQKSGL---HCIHPLVIHSENQHNNQNEIVVGEKVSI 639
            :|||.:....:|.|  |....|..:....:|:.|   .|:..::..|....|     ||.||:.|
Yeast   654 SILQETNIQPNLDM--IKNEVLTLMRTMQEKAELMYKDCVKKILNESPKFFN-----VVIEKIDI 711

  Fly   640 SNIAF 644
            ..:.|
Yeast   712 IRVDF 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	148/452 (33%)
CIN8	NP_010853.2	KISc_BimC_Eg5	34..486	CDD:276815	153/461 (33%)
		235kDa-fam	<520..978	CDD:130673	56/289 (19%)