Protein Alignment Kif3C and Kif3c

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_445938.1
• Gene: Kif3c / 85248
• RGDID: 621538
• Length: 796
• Species: Rattus norvegicus
• Alignment Length: 731
• Identity: 249/731 - (34%)
• Similarity: 373/731 - (51%)
• Gaps: 133/731 - (18%)

  Fly     2 SENIKVVVRCRPMNQTEKERNCQNI--VEINEFAVSVTNPSARISQ-QKKFIFDSVYNMKTDTEV 63
            ||.:|||.||||:::.|:....:.|  :::....|::.||.|...: .|.|.||:||:..:....
  Rat     8 SEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQAD 72

  Fly    64 IYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTTNV 128
            :|||....|::|.::|:|||:|||||||.|||:||||........|:||..|:|||..||.:.|.
  Rat    73 LYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQ 137

  Fly   129 RYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGN 193
            :||...:|||||.|.|||||:|.....:   .|||.|..||.:..|::....|..:....::.||
  Rat   138 QYLVRASYLEIYQEEIRDLLSKEPGKRL---ELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGN 199

  Fly   194 KNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRK----- 253
            :.|...:|.||:.|||||.||.||:|.|    ..|||....|..|||:||||||||||.|
  Rat   200 QARAVGSTHMNEVSSRSHAIFVITVECS----ERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNT 260

  Fly   254 ---------------------TGAQGDRLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLT 297
                                 :|:.|:|.||||:||||||||||||::|...::.|:|:||||||
  Rat   261 PGGPATQSTAGGGGGGGGTSGSGSSGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLT 325

  Fly   298 RLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEIL 362
            ||||||||||.||:|::.:.|....|||::||||:|:|||||.|||::||||||..||::|.||.
  Rat   326 RLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIA 390

  Fly   363 YLKRMLQESQQIINK-----------------------------------NNDPNKIIKSPLKII 392
            .||..| |.:.::.|                                   ||:.::..:..|:..
  Rat   391 RLKAQL-EKKGMLGKRPRRKSSRRKKAVSAPAGYPEGAVIEAWVAEEEDDNNNNHRPPQPTLEAA 454

  Fly   393 QHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSKEEV-----------QLQARSRID 446
            ...||.:....|...|... ||:.:.:.|::::....|::.||::           :|.|.....
  Rat   455 LEKNMENYLQEQKERLEEE-KAAIQDDRSLVSEEKQKLLEEKEKMLEDLKREQQATELLAAKYKA 518

  Fly   447 LIKRSLIGGERIHD--------FELKEKHMARKYAAQRHLSAIAIALSRVKCEDRDLLQGHYATI 503
            :..:.||||..|.|        .|||.:.:|.:...:|.:....:    ::.|:...|:|.|:::
  Rat   519 MESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEML----LRDEETMELRGTYSSL 579

  Fly   504 TQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDREDYLDEIRNLGRQVKFHQQLFLKFSSNPG 568
            .||:::|...::|...|::.::.|:.|.:.|:...|:| |:|.:|  .|.:   :|.||:
  Rat   580 QQEVEVKTKKLKKLYAKLQAVKAEIQDQHEEYIRVRQD-LEEAQN--EQTR---ELKLKY----- 633

  Fly   569 KFDRNWTP---DTILQNSLWND-DLKMWRIPESDLIKLPPATQKSGLHCIHPLVIHSEN--QHNN 627
            ....|:.|   ...:.|.|:.| :.:.|:                    ..|||....|  |...
  Rat   634 LIIENFIPPEEKNKIMNRLFLDCEEEQWK--------------------FQPLVPAGVNNSQMKK 678

  Fly   628 QNEIVVGEKVSISNIA 643
            :....||.|..||..|
  Rat   679 RPTSAVGYKRPISQYA 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	163/364 (45%)
Kif3c	NP_445938.1	KISc_KIF3	9..367	CDD:276822	163/364 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	251..292		8/40 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..421		2/23 (9%)
		Smc	<452..>637	CDD:440809	44/200 (22%)
		Globular. /evidence=ECO:0000255	633..793		17/87 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..796