DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and Kif3c

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_445938.1	Gene:	Kif3c / 85248	RGDID:	621538	Length:	796	Species:	Rattus norvegicus

Alignment Length:	731	Identity:	249/731 - (34%)
Similarity:	373/731 - (51%)	Gaps:	133/731 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SENIKVVVRCRPMNQTEKERNCQNI--VEINEFAVSVTNPSARISQ-QKKFIFDSVYNMKTDTEV 63
            ||.:|||.||||:::.|:....:.|  :::....|::.||.|...: .|.|.||:||:..:....
  Rat     8 SEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQAD 72

  Fly    64 IYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTTNV 128
            :|||....|::|.::|:|||:|||||||.|||:||||........|:||..|:|||..||.:.|.
  Rat    73 LYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAFEHIFTHISRSQNQ 137

  Fly   129 RYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGN 193
            :||...:|||||.|.|||||:|.....:   .|||.|..||.:..|::....|..:....::.||
  Rat   138 QYLVRASYLEIYQEEIRDLLSKEPGKRL---ELKENPETGVYIKDLSSFVTKNVKEIEHVMNLGN 199

  Fly   194 KNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRK----- 253
            :.|...:|.||:.|||||.||.||:|.|    ..|||....|..|||:||||||||||.|
  Rat   200 QARAVGSTHMNEVSSRSHAIFVITVECS----ERGSDGQDHIRVGKLNLVDLAGSERQNKAGPNT 260

  Fly   254 ---------------------TGAQGDRLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLT 297
                                 :|:.|:|.||||:||||||||||||::|...::.|:|:||||||
  Rat   261 PGGPATQSTAGGGGGGGGTSGSGSSGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDSKLT 325

  Fly   298 RLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEIL 362
            ||||||||||.||:|::.:.|....|||::||||:|:|||||.|||::||||||..||::|.||.
  Rat   326 RLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNEDPKDTLLREFQEEIA 390

  Fly   363 YLKRMLQESQQIINK-----------------------------------NNDPNKIIKSPLKII 392
            .||..| |.:.::.|                                   ||:.::..:..|:..
  Rat   391 RLKAQL-EKKGMLGKRPRRKSSRRKKAVSAPAGYPEGAVIEAWVAEEEDDNNNNHRPPQPTLEAA 454

  Fly   393 QHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSKEEV-----------QLQARSRID 446
            ...||.:....|...|... ||:.:.:.|::::....|::.||::           :|.|.....
  Rat   455 LEKNMENYLQEQKERLEEE-KAAIQDDRSLVSEEKQKLLEEKEKMLEDLKREQQATELLAAKYKA 518

  Fly   447 LIKRSLIGGERIHD--------FELKEKHMARKYAAQRHLSAIAIALSRVKCEDRDLLQGHYATI 503
            :..:.||||..|.|        .|||.:.:|.:...:|.:....:    ::.|:...|:|.|:::
  Rat   519 MESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQKRREREMQQEML----LRDEETMELRGTYSSL 579

  Fly   504 TQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDREDYLDEIRNLGRQVKFHQQLFLKFSSNPG 568
            .||:::|...::|...|::.::.|:.|.:.|:...|:| |:|.:|  .|.:   :|.||:
  Rat   580 QQEVEVKTKKLKKLYAKLQAVKAEIQDQHEEYIRVRQD-LEEAQN--EQTR---ELKLKY----- 633

  Fly   569 KFDRNWTP---DTILQNSLWND-DLKMWRIPESDLIKLPPATQKSGLHCIHPLVIHSEN--QHNN 627
            ....|:.|   ...:.|.|:.| :.:.|:                    ..|||....|  |...
  Rat   634 LIIENFIPPEEKNKIMNRLFLDCEEEQWK--------------------FQPLVPAGVNNSQMKK 678

  Fly   628 QNEIVVGEKVSISNIA 643
            :....||.|..||..|
  Rat   679 RPTSAVGYKRPISQYA 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	163/364 (45%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	159/357 (45%)
Kif3c	NP_445938.1	KISc_KIF3	9..367	CDD:276822	163/364 (45%)
		Kinesin	16..367	CDD:278646	159/357 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..292		8/40 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..421		2/23 (9%)
		GBP_C	<463..571	CDD:303769	22/112 (20%)
		coiled coil	540..551	CDD:293879	4/10 (40%)
		coiled coil	560..571	CDD:293879	1/14 (7%)
		Globular. /evidence=ECO:0000255	633..793		17/87 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..796
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820