DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and KIP1

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_009490.1	Gene:	KIP1 / 852216	SGDID:	S000000159	Length:	1111	Species:	Saccharomyces cerevisiae

Alignment Length:	725	Identity:	212/725 - (29%)
Similarity:	343/725 - (47%)	Gaps:	140/725 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEI-----NEFAVSVTNPSARISQQKKFIFDSVYNMKTDTEV 63
            ||.|.||||..|:.|.|.....::..     .|..:|..:..:..|.:|.:.||.|:..::|.|.
Yeast    52 NIHVYVRCRSRNKREIEEKSSVVISTLGPQGKEIILSNGSHQSYSSSKKTYQFDQVFGAESDQET 116

  Fly    64 IYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDEN------------FSNSTGIIPKCFD 116
            :::....:.::..:.|||.|||||||||.|||:||.||.|            .....||||:...
Yeast   117 VFNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSGDINILGDVQSTDNLLLGEHAGIIPRVLV 181

  Fly   117 HIFERISMTTNVRYLALVTYLEIYNERIRDLL---------------------NKNENTNVINHF 160
            .:|:.:| :.|..|...:::||:|||.::|||                     |.|.|::::...
Yeast   182 DLFKELS-SLNKEYSVKISFLELYNENLKDLLSDSEDDDPAVNDPKRQIRIFDNNNNNSSIMVKG 245

  Fly   161 LKELPGIGVSVPTLTTQPVVN-ANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFL 224
            ::|:              .:| |::..:.|..|:..|..|||..|..||||||:||||      .
Yeast   246 MQEI--------------FINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFTIT------T 290

  Fly   225 NSIGSDA--------FGGICRGKLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSL 281
            |.:..|:        |..|  |||:||||||||...::||:..|.:||..||.||..||.||::|
Yeast   291 NIVEQDSKDHGQNKNFVKI--GKLNLVDLAGSENINRSGAENKRAQEAGLINKSLLTLGRVINAL 353

  Fly   282 VDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKIN 346
            || .:.|:|:|:|||||||||||||.|||.:|:.|||..|..:||.|||.||:|||:|.|.|::|
Yeast   354 VD-HSNHIPYRESKLTRLLQDSLGGMTKTCIIATISPAKISMEETASTLEYATRAKSIKNTPQVN 417

  Fly   347 ED-PKDARLRQYQNEILYLKRMLQESQQIINKNNDPNKIIKSPLKIIQHTN-MNSTKNVQIIDLG 409
            :. .||..|:.|..||..|:..|:.|     :|.....|.:..|.:.:..: :...:|::|.:|.
Yeast   418 QSLSKDTCLKDYIQEIEKLRNDLKNS-----RNKQGIFITQDQLDLYESNSILIDEQNLKIHNLR 477

  Fly   410 RNCKASFKTN-------NSILTKPNFPLI-----------QSKEEVQLQARSRIDLIKRSLIGGE 456
            ...| .||.|       |::|......||           ....|:|....:.::|:...:
Yeast   478 EQIK-KFKENYLNQLDINNLLQSEKEKLIAIIQNFNVDFSNFYSEIQKIHHTNLELMNEVI---- 537

  Fly   457 RIHDFELKEKHMARKYAAQRHLSAIAIALSRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEKI 521
            :..||.|:...  ::|...:::.   :.:|:...:..:.|||..          |:|..||.|.|
Yeast   538 QQRDFSLENSQ--KQYNTNQNMQ---LKISQQVLQTLNTLQGSL----------NNYNSKCSEVI 587

  Fly   522 KMLEMEV------------SDLNSEFQLDREDYLDEIRNLGRQVKFHQQLFLKFSSNPGKFDRN- 573
            |.:..|:            |.|.|...:.....::::..|.|.:....::|...|::..:.|.|
Yeast   588 KGVTEELTRNVNTHKAKHDSTLKSLLNITTNLLMNQMNELVRSISTSLEIFQSDSTSHYRKDLNE 652

  Fly   574 --WTPDTILQNSLWNDDLK--MWRIPESDLIKLPPATQK--SGLHCIHPLVIHSENQHNNQNEIV 632
              .:....|:|  ..:|:|  :..|..|.|..:...:|.  :.|:.::.|:   |||.:..::::
Yeast   653 IYQSHQQFLKN--LQNDIKSCLDSIGSSILTSINEISQNCTTNLNSMNVLI---ENQQSGSSKLI 712

  Fly   633 VGEKVSISNI 642
            ..:.:.|..:
Yeast   713 KEQDLEIKKL 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	143/381 (38%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	139/375 (37%)
KIP1	NP_009490.1	KISc_BimC_Eg5	50..419	CDD:276815	147/390 (38%)
KIP1	NP_009490.1	235kDa-fam	<423..>948	CDD:130673	64/330 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910