Protein Alignment Kif3C and KIP1

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_009490.1
• Gene: KIP1 / 852216
• SGDID: S000000159
• Length: 1111
• Species: Saccharomyces cerevisiae
• Alignment Length: 725
• Identity: 212/725 - (29%)
• Similarity: 343/725 - (47%)
• Gaps: 140/725 - (19%)

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEI-----NEFAVSVTNPSARISQQKKFIFDSVYNMKTDTEV 63
            ||.|.||||..|:.|.|.....::..     .|..:|..:..:..|.:|.:.||.|:..::|.|.
Yeast    52 NIHVYVRCRSRNKREIEEKSSVVISTLGPQGKEIILSNGSHQSYSSSKKTYQFDQVFGAESDQET 116

  Fly    64 IYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDEN------------FSNSTGIIPKCFD 116
            :::....:.::..:.|||.|||||||||.|||:||.||.|            .....||||:...
Yeast   117 VFNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSGDINILGDVQSTDNLLLGEHAGIIPRVLV 181

  Fly   117 HIFERISMTTNVRYLALVTYLEIYNERIRDLL---------------------NKNENTNVINHF 160
            .:|:.:| :.|..|...:::||:|||.::|||                     |.|.|::::...
Yeast   182 DLFKELS-SLNKEYSVKISFLELYNENLKDLLSDSEDDDPAVNDPKRQIRIFDNNNNNSSIMVKG 245

  Fly   161 LKELPGIGVSVPTLTTQPVVN-ANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFL 224
            ::|:              .:| |::..:.|..|:..|..|||..|..||||||:||||      .
Yeast   246 MQEI--------------FINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFTIT------T 290

  Fly   225 NSIGSDA--------FGGICRGKLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSL 281
            |.:..|:        |..|  |||:||||||||...::||:..|.:||..||.||..||.||::|
Yeast   291 NIVEQDSKDHGQNKNFVKI--GKLNLVDLAGSENINRSGAENKRAQEAGLINKSLLTLGRVINAL 353

  Fly   282 VDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKIN 346
            || .:.|:|:|:|||||||||||||.|||.:|:.|||..|..:||.|||.||:|||:|.|.|::|
Yeast   354 VD-HSNHIPYRESKLTRLLQDSLGGMTKTCIIATISPAKISMEETASTLEYATRAKSIKNTPQVN 417

  Fly   347 ED-PKDARLRQYQNEILYLKRMLQESQQIINKNNDPNKIIKSPLKIIQHTN-MNSTKNVQIIDLG 409
            :. .||..|:.|..||..|:..|:.|     :|.....|.:..|.:.:..: :...:|::|.:|.
Yeast   418 QSLSKDTCLKDYIQEIEKLRNDLKNS-----RNKQGIFITQDQLDLYESNSILIDEQNLKIHNLR 477

  Fly   410 RNCKASFKTN-------NSILTKPNFPLI-----------QSKEEVQLQARSRIDLIKRSLIGGE 456
            ...| .||.|       |::|......||           ....|:|....:.::|:...:
Yeast   478 EQIK-KFKENYLNQLDINNLLQSEKEKLIAIIQNFNVDFSNFYSEIQKIHHTNLELMNEVI---- 537

  Fly   457 RIHDFELKEKHMARKYAAQRHLSAIAIALSRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEKI 521
            :..||.|:...  ::|...:::.   :.:|:...:..:.|||..          |:|..||.|.|
Yeast   538 QQRDFSLENSQ--KQYNTNQNMQ---LKISQQVLQTLNTLQGSL----------NNYNSKCSEVI 587

  Fly   522 KMLEMEV------------SDLNSEFQLDREDYLDEIRNLGRQVKFHQQLFLKFSSNPGKFDRN- 573
            |.:..|:            |.|.|...:.....::::..|.|.:....::|...|::..:.|.|
Yeast   588 KGVTEELTRNVNTHKAKHDSTLKSLLNITTNLLMNQMNELVRSISTSLEIFQSDSTSHYRKDLNE 652

  Fly   574 --WTPDTILQNSLWNDDLK--MWRIPESDLIKLPPATQK--SGLHCIHPLVIHSENQHNNQNEIV 632
              .:....|:|  ..:|:|  :..|..|.|..:...:|.  :.|:.::.|:   |||.:..::::
Yeast   653 IYQSHQQFLKN--LQNDIKSCLDSIGSSILTSINEISQNCTTNLNSMNVLI---ENQQSGSSKLI 712

  Fly   633 VGEKVSISNI 642
            ..:.:.|..:
Yeast   713 KEQDLEIKKL 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	143/381 (38%)
KIP1	NP_009490.1	KISc_BimC_Eg5	50..419	CDD:276815	147/390 (38%)
		235kDa-fam	<423..>948	CDD:130673	64/330 (19%)
		AAA_13	<562..>741	CDD:463796	35/176 (20%)