Protein Alignment Kif3C and Kif4a

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001387859.1
• Gene: Kif4a / 84393
• RGDID: 620526
• Length: 1231
• Species: Rattus norvegicus
• Alignment Length: 680
• Identity: 228/680 - (33%)
• Similarity: 342/680 - (50%)
• Gaps: 122/680 - (17%)

  Fly     1 MSENIK-----VVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTD 60
            |.|.:|     |.:||||:...|....||..:   .|...  .|...:...|.|.:|.|::..|:
  Rat     1 MKEEVKGIPVRVALRCRPLVSKEINEGCQTCL---SFVPG--EPQVVVGTDKSFTYDFVFDPSTE 60

  Fly    61 TEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQG----DENFSNSTGIIPKCFDHIFER 121
            .|.:::.....|::...:|||.|:.||||||.|||::|.|    ::...::.|:||:....:|:.
  Rat    61 QEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKE 125

  Fly   122 ISMTTNVRYLALVTYLEIYNERIRDLL-NKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQC 185
            |:..|:..:...|:|||||||.|.||| :..|..:.||  ::|.|..|:.:..||.:.|:.|:..
  Rat   126 INKKTDFEFTLKVSYLEIYNEEILDLLCSSREKASQIN--IREDPKEGIKIVGLTEKTVLVASDT 188

  Fly   186 YDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSER 250
            ...|..||..|..|:|.||..|||||.||||::||..  .:..:.:|    |.||.|||||||||
  Rat   189 VSCLEQGNNCRTVASTAMNSQSSRSHAIFTISIEQRK--KNDKNSSF----RSKLHLVDLAGSER 247

  Fly   251 QRKTGAQGDRLKEASQINLSLSALGNVISSLVDG-KAKHVPFRDSKLTRLLQDSLGGNTKTLMIS 314
            |:||.|:||||||...||..|..||||||:|.|. |...||:||||||||||||||||:.||||:
  Rat   248 QKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIA 312

  Fly   315 CISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQESQQII---- 375
            |:||.|.:.:||::|||||.||:.|.|||.||.||:.|       |:.:||:.:|:.|.::
  Rat   313 CVSPADSNLEETLNTLRYADRARKIKNKPIINIDPQAA-------ELNHLKQQVQQLQVLLLQAH 370

  Fly   376 ------NKNNDPNKIIKSPLKIIQHTNMNSTKNVQIID----LGRN-CKASFKT----NNSILTK 425
                  |.|..|::.::|.::          ||..:::    |.|. .:|:.:|    ...|||:
  Rat   371 GGTLPGNINVKPSENLQSLME----------KNQSLVEENEKLSRGLSEAAGQTAQMLERIILTE 425

  Fly   426 PNFPLIQSK-EEVQLQARSRIDLIKRSLIGGERIHDFELKE--KHMARKYAAQRHLSAIAIALSR 487
            .....:.:| ||::..|..::||.|.:    |.:.|.|:||  :.:.....|...||..|:|...
  Rat   426 QANEKMNAKLEELRQHAACKVDLQKLA----ETLEDQEVKENIEIICNLQQAIARLSDEAVACMT 486

  Fly   488 VKCEDRDLLQGHYATI--TQEIDI---------KNDYIRKCKEKIKMLEM--EVSDLNSEFQL-- 537
                         |||  ..|:|.         ::..:...:..::..:|  |:.:||.|..|
  Rat   487 -------------ATIDTAGEVDTQEQSSPDTSRSSDVFSTQHALRQAQMSKELIELNKELALKE 538

  Fly   538 ---------DRE------DYLDEIRNLGRQV----KFHQQLFLKFSS-----NPGKF-DRNWTPD 577
                     |.:      .|.|.|:||..:|    |..::|.|:..:     |..|. :|.....
  Rat   539 ALAKKMTQNDNQLQPIQFQYQDNIKNLELEVLSLQKEKEELVLELQTAKKDVNQAKLSERRRKRL 603

  Fly   578 TILQNSLWNDDLKMWRIPESDLIKLPPATQ 607
            ..|:..:  .:||.....:|.|:||...|:
  Rat   604 QELEGQI--AELKKKLHEQSKLLKLKETTE 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	151/346 (44%)
Kif4a	NP_001387859.1	KISc_KIF4	8..338	CDD:276823	149/342 (44%)
		PTZ00121	<397..1039	CDD:173412	56/254 (22%)
		SMC_prok_B	550..>865	CDD:274008	20/84 (24%)
		SET	1084..>1121	CDD:394802