DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and Kif3a

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_006246409.1	Gene:	Kif3a / 84392	RGDID:	621536	Length:	726	Species:	Rattus norvegicus

Alignment Length:	668	Identity:	252/668 - (37%)
Similarity:	361/668 - (54%)	Gaps:	110/668 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ENIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQ--KKFIFDSVYNMKTDTEVIY 65
            :|:||||||||:|:.||....:..|.::|...::|......|.:  |.|.||:|:..::....:|
  Rat    13 DNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQLDVY 77

  Fly    66 DEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTT-NVR 129
            :.....:::|.:||||||||||||||.|||.||:|........|:||..|.|||..|:... :.|
  Rat    78 NLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHIAKAEGDTR 142

  Fly   130 YLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGNK 194
            :|..|:|||||||.:||||.|::...:   .:||.|.:||.:..|:...|.||:.....:..|:|
  Rat   143 FLVRVSYLEIYNEEVRDLLGKDQTQRL---EVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHK 204

  Fly   195 NRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGD 259
            ||...||.||::|||||.|||||:|.|    ..|.|....:..|||.||||||||||.||||.|.
  Rat   205 NRSVGATNMNEHSSRSHAIFTITIECS----EKGVDGNMHVRMGKLHLVDLAGSERQAKTGATGQ 265

  Fly   260 RLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYD 324
            |||||::||||||.||||||:|||||:.|||:|:||||||||||||||:||:|.:.|.|.|.:||
  Rat   266 RLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYD 330

  Fly   325 ETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQESQQ---------------- 373
            |||||||||:|||||.||.:||||||||.|||:|.||..||:.|:|.::
  Rat   331 ETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDNEE 395

  Fly   374 ---------------------------IINKNND-------------PNKIIKSPLKIIQHTNMN 398
                                       :|.|..|             |:|:::...||.:.....
  Rat   396 GELGEDGEKRKKRRGSSSSSSSDSTCSVIEKPLDEFLPHQAGKKKVSPDKMMEMQAKIDEERKAL 460

  Fly   399 STKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSKEEVQLQARSRIDLIKRSLIGG-------- 455
            .|| :.:.:..|| ||     .:.|.:....|:::::|.|........|.|:.::||
  Rat   461 ETK-LDMEEEERN-KA-----RAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAE 518

  Fly   456 --ERI---HDFELKEKHMARKYAAQRHLSAIAIALSRVKCEDRDLLQGHYATITQEIDIKNDYIR 515
              |::   .:.||:|:   ||.|.|...........|:..|::      |.::.:|...|...::
  Rat   519 EQEKLLEESNMELEER---RKRAEQLRKELEEKEQERLDIEEK------YTSLQEEAQGKTKKLK 574

  Fly   516 KCKEKIKMLEMEVSDLNSEFQLDREDYLDEIRNLGRQVKFHQQLFLKFSSNPGKFDRNWTP---D 577
            |....:...:.|::||..|.|.:.|..|:.||.|.|:::. |.|.:.          |:.|   .
  Rat   575 KVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRL-QMLIID----------NFIPQDYQ 628

  Fly   578 TILQNSL-WNDDLKMWRI 594
            .:::|.: ||:|:..|::
  Rat   629 EMIENYVHWNEDIGEWQL 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	175/338 (52%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	170/331 (51%)
Kif3a	XP_006246409.1	KISc_KIF3	13..345	CDD:276822	175/338 (52%)
		Kinesin	20..345	CDD:278646	170/331 (51%)
		CENP-F_leu_zip	434..574	CDD:287450	31/155 (20%)
		GBP_C	<446..611	CDD:303769	40/180 (22%)
		coiled coil	597..608	CDD:293879	4/10 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820