DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif3C and ZCF125

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_564744.1	Gene:	ZCF125 / 842245	AraportID:	AT1G59540	Length:	823	Species:	Arabidopsis thaliana

Alignment Length:	745	Identity:	231/745 - (31%)
Similarity:	328/745 - (44%)	Gaps:	172/745 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ENIKVVVRCRPMNQTEKERNCQNI--VEINEFAV--SVTNPSARISQQKKFIFDSVYNMKTDTEV 63
            |.|.|.||.||    ....|..::  ||.|..::  |:..|....|.    .||.|::..:....
plant     2 EKICVAVRVRP----PAPENGASLWKVEDNRISLHKSLDTPITTASH----AFDHVFDESSTNAS 58

  Fly    64 IYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTTNV 128
            :|:.:...::.:.:||:|||.||||||..|||.||.|.|   ...|||.:....:||||.|.::.
plant    59 VYELLTKDIIHAAVEGFNGTAFAYGQTSSGKTFTMTGSE---TDPGIIRRSVRDVFERIHMISDR 120

  Fly   129 RYLALVTYLEIYNERIRDLLN-KNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFG 192
            .:|..|:|:|||||.|.|||. :|:...:..|..:     ||.|..|..:.|.:|.|....:..|
plant   121 EFLIRVSYMEIYNEEINDLLAVENQRLQIHEHLER-----GVFVAGLKEEIVSDAEQILKLIDSG 180

  Fly   193 NKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQ 257
            ..||....|.||.:||||||||.:.:|.....|| .|||   |....|:|||||||||..||||.
plant   181 EVNRHFGETNMNVHSSRSHTIFRMVIESRGKDNS-SSDA---IRVSVLNLVDLAGSERIAKTGAG 241

  Fly   258 GDRLKEASQINLSLSALGNVISSLVDGK--AKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTD 320
            |.||:|...||.||..|||||:.|.|..  ..|:|:|||||||:||.:||||.||.:|..|:|.:
plant   242 GVRLQEGKYINKSLMILGNVINKLSDSTKLRAHIPYRDSKLTRILQPALGGNAKTCIICTIAPEE 306

  Fly   321 IHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQN-EILYLKRMLQES------QQIINKN 378
            .|.:|:..||::|||||.|:|..::||...||.|.:.|. ||..|:..||.|      |:|:|.:
plant   307 HHIEESKGTLQFASRAKRITNCAQVNEILTDAALLKRQKLEIEELRMKLQGSHAEVLEQEILNLS 371

  Fly   379 NDPNKIIKSPLKIIQ-HTNMNSTKNVQIIDLGRNC----KASFKTNNSILTKPNFPLIQSKEEV- 437
               |:::|..|:..: .|.:...|..|  ....||    :...:..|:.:|..:|...||::.:
plant   372 ---NQMLKYELECERLKTQLEEEKRKQ--KEQENCIKEQQMKIENLNNFVTNSDFKRNQSEDFII 431

  Fly   438 ---------------------QLQARSRIDLIKRSLIGGERIHDFELKEKHMARKYAAQRHLSAI 481
                                 ..::.||..::.||                  ..|:.....|.:
plant   432 SRKTPDGLCNVNDTSDVPGTPCFKSASRSFVVARS------------------NNYSGLSDFSPM 478

  Fly   482 AIALSRVKCED--RDLLQGHYATITQEIDIKNDYIRKCK---------EKIKMLEMEVSDLNSEF 535
            ..:|..|..||  ..|.:|..|.:.|   |:.....||:         |..:....||.||.|..
plant   479 VHSLGDVADEDTWMKLNKGFVADLDQ---IQFTPAVKCQPTPLSIATTECPRENHSEVEDLKSRI 540

  Fly   536 QL--DREDYLDEIRNLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSLWNDDLKMWRIPES- 597
            ||  :..|.|        ||||::|:.|  |:|..:.......:|:....:.|      |:.||
plant   541 QLLTNENDSL--------QVKFNEQVLL--SNNLMQEMSELKQETLTVKEIPN------RLSESV 589

  Fly   598 --------DLI----------KLPPAT--------------------------QKSGLHCIHPLV 618
                    |:|          :.|.|.                          ||:|....|||.
plant   590 ANCKDVYKDVIVTMKSLITDKESPTANLLLGTTEITTSLLATLETQFSMIMDGQKTGSSIDHPLS 654

  Fly   619 IHSENQHNNQNEIVVGEKVSISNIAFLFLS 648
            .|.|..           :|::.|...|.||
plant   655 DHWETL-----------RVNLKNTTTLLLS 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	144/342 (42%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	140/335 (42%)
ZCF125	NP_564744.1	KISc_CENP_E	3..325	CDD:276825	143/341 (42%)
		Kinesin	9..325	CDD:278646	140/335 (42%)
		Cortex-I_coil	711..787	CDD:286397
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910