DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif3C and AT4G39050

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_195616.2	Gene:	AT4G39050 / 830060	AraportID:	AT4G39050	Length:	1055	Species:	Arabidopsis thaliana

Alignment Length:	574	Identity:	184/574 - (32%)
Similarity:	282/574 - (49%)	Gaps:	51/574 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ENIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTEVIYDE 67
            ::|.|.||.||::..|.:|.    .|:..:....|......:....:.||.|:..:..|..:||.
plant    97 DSISVTVRFRPLSDREYQRG----DEVAWYPDGDTLVRHEYNPLTAYAFDKVFGPQATTIDVYDV 157

  Fly    68 MCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTTNVRYLA 132
            ....:|::.:||.|||:||||.|..||||||.||:   .|.||||.....:|..|..|....:|.
plant   158 AARPVVKAAMEGVNGTVFAYGVTSSGKTHTMHGDQ---ESPGIIPLAIKDVFSIIQDTPGREFLL 219

  Fly   133 LVTYLEIYNERIRDLLN-KNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGNKNR 196
            .|:|||||||.|.|||: ..:|..|     :| ...|..|..:..:.|::......::..|.::|
plant   220 RVSYLEIYNEVINDLLDPTGQNLRV-----RE-DSQGTYVEGIKEEVVLSPGHALSFIAAGEEHR 278

  Fly   197 VTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGDRL 261
            ...:...|..|||||||||:.:|     :|...|.:.|:...:|:|:|||||| ..||...|.|.
plant   279 HVGSNNFNLLSSRSHTIFTLMVE-----SSATGDEYDGVIFSQLNLIDLAGSE-SSKTETTGLRR 337

  Fly   262 KEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYDET 326
            ||.|.||.||..||.||..|.:|||.|:|:||||||||||.||.|:....:|..|:|.....:||
plant   338 KEGSYINKSLLTLGTVIGKLSEGKATHIPYRDSKLTRLLQSSLSGHGHVSLICTITPASSSSEET 402

  Fly   327 ISTLRYASRAKNISNKPKINE--DPKDARLRQYQNEILYLKRMLQESQQ--IINKNNDPNKIIKS 387
            .:||::|||||:|......|:  |.| :.:::||.||..||..|.:.::  ::..:::....:|.
plant   403 HNTLKFASRAKSIEIYASRNQIIDEK-SLIKKYQREISTLKLELDQLRRGMLVGVSHEELMSLKQ 466

  Fly   388 PLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSKEEVQLQARSRIDLIKRSL 452
            .|:..| ..|.|.     ::.....||:..:....|||  ..|:.:|..:...: ..|...:|||
plant   467 QLEEGQ-VKMQSR-----LEEEEEAKAALMSRIQKLTK--LILVSTKNSIPGYS-GDIPTHQRSL 522

  Fly   453 IGG--ERIHDFELKEKHMARKYAAQRHLSAIAIAL----SRVKCEDRDLLQGHYATITQEIDIKN 511
            ..|  ::.....|:..::....:....||..::..    |..|..|.:   ...|..||.: :..
plant   523 SAGKDDKFDSLLLESDNLGSPSSTLALLSEGSLGFNHRRSSSKLNDEN---SPGAEFTQGV-MTP 583

  Fly   512 DYIRKCKEKIKMLEMEVSDLNSEFQL-------DREDYLDEIRNLGRQVKFHQQ 558
            |.|....|::|||..|::...|..:.       |.|:...:|:||.|::...|:
plant   584 DEIDLLVEQVKMLAGEIAFSTSTLKRLVDQSVNDPENSQTQIQNLEREIHEKQR 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	132/336 (39%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	129/329 (39%)
AT4G39050	NP_195616.2	KISc_CENP_E	98..415	CDD:276825	132/335 (39%)
		SMC_prok_B	624..>914	CDD:274008	5/14 (36%)
		zf-C3HC4_3	1004..1049	CDD:404755
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910