DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and KIF18A

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_112494.3	Gene:	KIF18A / 81930	HGNCID:	29441	Length:	898	Species:	Homo sapiens

Alignment Length:	712	Identity:	210/712 - (29%)
Similarity:	310/712 - (43%)	Gaps:	190/712 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSENIKVVVRCRPMNQTEKERNCQNIVEINEFAVSV----------------TNPSARISQQK-- 47
            :..::|||||.||.|..||......:|.:.:..:.|                ||.:....|.|
Human     8 LCHHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTTNQNVIKKQNKDL 72

  Fly    48 KFIFDSVYNMKTDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGI-- 110
            ||:||:|::..:....:::.....::.|.:.|||.|:.|||.||.||||||.|.   ::..|:
Human    73 KFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGS---ADEPGVMY 134

  Fly   111 -----IPKCFDHIFERISMTTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVS 170
                 :.||.|.|.|....:|      .|:|||:|||:|||||..:....|     :|....||.
Human   135 LTMLHLYKCMDEIKEEKICST------AVSYLEVYNEQIRDLLVNSGPLAV-----REDTQKGVV 188

  Fly   171 VPTLTTQPVVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGI 235
            |..||.....::.:....|..|||||....|.||..|||||.:|.|.|.|.....||..:    :
Human   189 VHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASINQN----V 249

  Fly   236 CRGKLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAK--HVPFRDSKLTR 298
            ...|:||:|||||||...:||:|.|..|.:.||.||.||||||::|.|.|.|  |:|:|:|||||
Human   250 RIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKRKNQHIPYRNSKLTR 314

  Fly   299 LLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQY------ 357
            ||:||||||.:|:||:.:||:.:.||:|.:||:||:|||:|.:..|.|....:..:.||
Human   315 LLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQYVKICNE 379

  Fly   358 -QNEILYLKRML---QESQQIINKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKT 418
             :.|||.||..|   :|.:...|:|:....:|.:|          ..|.::......||
Human   380 QKAEILLLKEKLKAYEEQKAFTNENDQAKLMISNP----------QEKEIERFQEILNC------ 428

  Fly   419 NNSILTKPNFPLIQSKEEVQLQARSRIDLIKRSLIGGERIHDFELKEKHMARKYAAQRHLSAIAI 483
                       |.|::||:      |.:.:|..::         |||..:...|..|.| ..|.:
Human   429 -----------LFQNREEI------RQEYLKLEML---------LKENELKSFYQQQCH-KQIEM 466

  Fly   484 ALSRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDREDYLDEIRN 548
            ..|..|.|.....:.|                    ::.||:            .|..||::.|.
Human   467 MCSEDKVEKATGKRDH--------------------RLAMLK------------TRRSYLEKRRE 499

  Fly   549 LGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSLWNDDLKMWRIPESDLIKLPPATQKSGLHC 613
              .::|              :||.|       .|.|...:.:|..:.::..|   |...|..|||
Human   500 --EELK--------------QFDEN-------TNWLHRVEKEMGLLSQNGHI---PKELKKDLHC 538

  Fly   614 IHPLVIHSEN------------------QHNNQNEIVVG-------------EKVSISNIAF 644
            .|   :|.:|                  |.:.|.|.|:.             ::..:||.||
Human   539 HH---LHLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYCTLKEAGLSNAAF 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	144/362 (40%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	140/355 (39%)
KIF18A	NP_112494.3	KISc_KIP3_like	11..355	CDD:276821	144/361 (40%)
		Kinesin	17..355	CDD:278646	140/355 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..690
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..871
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910