DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and kif5ab

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_009301044.1	Gene:	kif5ab / 799274	ZFINID:	ZDB-GENE-110510-3	Length:	1050	Species:	Danio rerio

Alignment Length:	571	Identity:	184/571 - (32%)
Similarity:	290/571 - (50%)	Gaps:	65/571 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTEVIYDEM 68
            ||:|:.|.||:||:|       |:..::|..:.......|...:.::||.|:......|.:|:..
Zfish     9 NIRVLCRFRPLNQSE-------ILRGDKFMPTFQGDDTVIIAGRSYVFDKVFPTNCTQEQVYNTC 66

  Fly    69 CYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERI-SMTTNVRYLA 132
            ...:|:..::||||||||||||..|||:||:|..:.:|..||||:..:.||..| :|..|:.:..
Zfish    67 AQQIVKDVLDGYNGTIFAYGQTSSGKTYTMEGKLHDANGRGIIPRIAEDIFNHIYTMDENLEFHI 131

  Fly   133 LVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGNKNRV 197
            .|:|.|||.::|||||:..:....::.....:|    .|...|.:.|.:..:..|.:..|..||.
Zfish   132 KVSYFEIYMDKIRDLLDVTKTNLSVHEDKNRVP----YVKGCTERFVSSPEEVMDLIDEGKANRH 192

  Fly   198 TAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGDRLK 262
            .|.|.||::|||||:||.|.::|...      :....:| |||.||||||||:..||||:|..|.
Zfish   193 VAVTNMNEHSSRSHSIFLINIKQEHV------ETEQKLC-GKLYLVDLAGSEKVSKTGAEGAVLD 250

  Fly   263 EASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYDETI 327
            ||..||.||||||||||:|.:|...|||:||||:||:||||||||.:|.|..|.||:..:..||.
Zfish   251 EAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTMFICCSPSAYNDAETK 315

  Fly   328 STLRYASRAKNISNKPKIN-EDPKDARLRQYQNE---ILYLKRMLQESQQIINK-NNDPNKIIKS 387
            |||.:..|||.|.|...:| |...:...|:|:.|   ...||..:|..:..:|. .|..:.::.:
Zfish   316 STLMFGQRAKTIMNSASVNLELTAEQWKRKYEKEKEKNKDLKESMQRLEAELNHWRNGESVVLIT 380

  Fly   388 PLK-----IIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSKEEVQLQARSRIDL 447
            |:.     :.:.|.:::..:.|...:.....:.::.....|.:   .|....:|:.||.: .::.
Zfish   381 PVSPAECDVTEDTAVDNQSHGQTELIPEQHNSRYEEEIQQLYR---QLDDKDDEINLQCQ-LVEK 441

  Fly   448 IKRSLIGGERI-----HDFE--------LKEKHMARKYAAQRHLSA---IAIALSRVKCEDRDLL 496
            :|..::..|.:     .|.|        |:....:.|...|..|.|   :|::......|.:|..
Zfish   442 LKEQMLDQEELLACARADLERVQCDVRRLQADSESSKLEVQEVLQALEELALSYDHKSLEAQDNS 506

  Fly   497 QGHYATITQE--------IDIKNDYIR-------KCKEKIKMLEMEVSDLN 532
            : |...:|:|        :.:::|:.|       :.|...::|...|.|||
Zfish   507 R-HNRRLTEELAHTTSALLSLESDFSRLQEVNGQQRKRITEVLNTLVKDLN 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	141/335 (42%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	138/329 (42%)
kif5ab	XP_009301044.1	KISc_KHC_KIF5	7..327	CDD:276820	141/335 (42%)
		KISc	9..334	CDD:214526	143/342 (42%)
		DUF2570	847..964	CDD:305162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910