Protein Alignment Kif3C and cenpe

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001314688.1
• Gene: cenpe / 767754
• ZFINID: ZDB-GENE-060929-860
• Length: 2690
• Species: Danio rerio
• Alignment Length: 723
• Identity: 217/723 - (30%)
• Similarity: 324/723 - (44%)
• Gaps: 156/723 - (21%)

  Fly     1 MSEN--IKVVVRCRPMNQTEKERNC-----------QNIVEINEFAVSVTNPSARISQQKKFIFD 52
            |:|.  :||.||.||:.:.|...:.           |.|.:::|..          :|.|.:.||
Zfish     1 MTEESAVKVCVRVRPLIKREASESSEPVQLYWRSDKQAIHQLDEDG----------AQTKSYSFD 55

  Fly    53 SVYNMKTDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDH 117
            .|::....|..:|.::...||.|.:|||||||||||||..|||.||.|.|   ::.|:||.....
Zfish    56 RVFSAAESTAQLYQDIAKPLVVSAVEGYNGTIFAYGQTSSGKTFTMMGSE---HNPGVIPLAMAD 117

  Fly   118 IFERISMTTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNA 182
            :|:.|.......:|..|:|:|||||.:.|||..:.....:.  ::|.....|.|..||.:.|.:.
Zfish   118 VFKTIKSFPKKEFLLRVSYMEIYNETVTDLLCDSWKRKPLE--IREGNYKNVYVADLTEELVTSP 180

  Fly   183 NQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLE----QSPFLNSIGSDAFGGICRGKLSLV 243
            .|...|:..|.|||....|.||:.||||||||.:.||    ..|   :.|..|.|.|....|:||
Zfish   181 EQALSWITKGEKNRHYGKTKMNQRSSRSHTIFRMILESRERSDP---TAGESADGAIIVSHLNLV 242

  Fly   244 DLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAK-HVPFRDSKLTRLLQDSLGGN 307
            ||||:||..:|||:|.|.||...||.||..||.||..|.|...| .:.:|||||||:||:|||||
Zfish   243 DLAGAERASQTGAEGARFKEGCNINRSLFTLGQVIKKLSDESQKGFLNYRDSKLTRILQNSLGGN 307

  Fly   308 TKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINE-DPKDARLRQYQNEILYLKRMLQES 371
            .||::|..|:|..:  |||:|||::||.||.:.|.|.:.| ..:.|.||:|:|||:.|||.|||.
Zfish   308 AKTVIICTITPATV--DETVSTLQFASAAKRMKNDPHVTEVSDEGALLRRYRNEIVDLKRRLQEV 370

  Fly   372 QQIINKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSKEE 436
            ..:                    |...:|:...:      |:                |:|.|::
Zfish   371 SSV--------------------TQTTATERESL------CQ----------------LLQEKDQ 393

  Fly   437 VQLQARSRIDLIKRSLI------------------GGERIHDFELKEKHM-------ARKYAAQR 476
            :|.:...||..:.:.|:                  ||:.:....|..:.:       |..|..:|
Zfish   394 LQREQEDRIKNLTKLLVTSSNIALIPKVPKRRVTWGGKLLRSAHLLNEDLCSTDMSFAEPYLKKR 458

  Fly   477 HLSAIAIALSRVKC------EDRDLLQGHYATITQE-----IDIKNDYIRKCKE--------KIK 522
                      |..|      ||.|.....:.....|     :::.:..:|...|        :..
Zfish   459 ----------RADCSLADVGEDMDEFDSRFDFTAMEEPNMDMEMSSITVRSSSEGSHFLDSPRAS 513

  Fly   523 MLEMEVSDLNSEFQLDRED-YLDEIRNLGRQVKF-HQQLFLKFSSNPGKFDRNWTPDTILQNSLW 585
            .|..:||.|.|:.:.:.:. .:.|..|...|:|. |.|..|:..|.|...::|    ||.:....
Zfish   514 ELMQKVSSLESQLEAETQSKQIAEEMNAELQMKLSHLQNMLEAQSAPSHEEKN----TISELEKQ 574

  Fly   586 NDDLKMWRIPESDLIKLPPATQKS--------GLHCIHPLVIHSEN-----QHNNQNEIVVGEKV 637
            .:||:  |..|:::.:...|.:||        .|......::||:|     :.:.:..|.:.|.|
Zfish   575 MEDLQ--RRLETEVQERQTAEEKSISLELKVAELEKPSEELLHSQNTCERVKKDLEEAIQLCETV 637

  Fly   638 SISNIAFL 645
            |....|.:
Zfish   638 SFEKDAVI 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	143/353 (41%)
cenpe	NP_001314688.1	KISc_CENP_E	6..337	CDD:276825	142/350 (41%)
		SMC_prok_B	512..1266	CDD:274008	33/140 (24%)
		SMC_prok_B	<917..1759	CDD:274008
		Smc	<1486..>2047	CDD:440809
		sbcc	1716..2415	CDD:129705