Protein Alignment Kif3C and Kif18b

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_932063.2
• Gene: Kif18b / 70218
• MGIID: 2446979
• Length: 834
• Species: Mus musculus
• Alignment Length: 779
• Identity: 214/779 - (27%)
• Similarity: 341/779 - (43%)
• Gaps: 192/779 - (24%)

  Fly     5 IKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNP-------------SARISQQKK-----FIF 51
            ::||||.||....|.|...:.::::.:..:.|.:|             .:....:||     |:|
Mouse    10 VRVVVRVRPPTPKELESQRRPVIQVVDERMLVFDPEECDGGFPGLKWSGSHNGPKKKGKDLTFVF 74

  Fly    52 DSVYNMKTDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFD 116
            |.|:......|.::....:::::|.::|||.::||||.||.||||||.|.|   ...||:.....
Mouse    75 DRVFGEMATQEDVFQHTTHNILDSFLQGYNCSVFAYGATGAGKTHTMLGRE---GEPGIMYLTTM 136

  Fly   117 HIFERI-SMTTNVRYLALVTYLEIYNERIRDLLN-KNENTNVINHFLKELPGIGVSVPTLTTQPV 179
            .::.|: :.....::..|::|||:|||:|.|||. |...|      ::|.|..||.||.|:....
Mouse   137 ELYRRLEARQEEKQFEVLISYLEVYNEQIHDLLEPKGPLT------IREDPDKGVVVPGLSFHQP 195

  Fly   180 VNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICR----GKL 240
            .:|.|..:.|..||.:|....|..|..|||||.||.|.::|        .|...|:.:    .|:
Mouse   196 ASAEQLLEMLTRGNCSRTQHPTDANATSSRSHAIFQIFVKQ--------QDRVPGLTQALRVAKM 252

  Fly   241 SLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD--GKAKHVPFRDSKLTRLLQDS 303
            ||:|||||||...|.|:|:||:|.:.||.||.||.||:::|.|  |:..|||:|||||||||:||
Mouse   253 SLIDLAGSERASSTHAKGERLREGANINRSLLALINVLNALADAKGRKSHVPYRDSKLTRLLKDS 317

  Fly   304 LGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQY-------QNEI 361
            :|||.:|:||:.|||:.:.|::|.:||:||.|||.|....|.|....|..:.||       |.|:
Mouse   318 IGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEIRLTLKSNVISVDHHISQYATICQQLQAEV 382

  Fly   362 LYLKRMLQ---ESQQIINKNNDPNKIIKSPLKIIQHTNMNS---------------TKN--VQII 406
            .:|:..||   ...|.:.:...|.   ...|.|.|..:.:|               .||  :|..
Mouse   383 AFLREKLQMYEAGAQALQQQCSPQ---PPTLSIPQSLSSSSLQPGPSSQSSTLECHAKNETLQEE 444

  Fly   407 DLGRNCKASFKTNNSI---------------LTKPNF-----PLIQSK----------------E 435
            .||.:.:.......|.               ..:||.     |.:|:|                :
Mouse   445 SLGSDAQGQEIVEESASEQEQCPQDKQCPTQKPEPNLPGSPSPSVQAKPGTGQHSPQKQDADHSK 509

  Fly   436 EVQLQ----ARSRIDLIK-RSLIGGERIHDFELKEKHMARKYAAQRHLSAIAIALSR------VK 489
            ::.||    |:.:..|:: .:|:..:.|.:||..::.:..:....|..|..:.||:|      ..
Mouse   510 QLALQVLRLAQRQYSLLQAANLLTPDMISEFETLQQLVLEESVDHRAESPRSPALARGDPLAQAL 574

  Fly   490 CEDRDLLQGHYATITQEI-----------------DIKND--YIRKCKEKIKMLEME----VSDL 531
            |.: ....|:...:|:.:                 |..:|  :.:..|||.:.|..|    :...
Mouse   575 CSE-SKSSGYCGPVTRTMAKQLNGLTHTLGAPLAPDCTSDKTFQKPTKEKKRKLTPEEPGSLPAP 638

  Fly   532 NSEFQLDREDYLDEIR----------NLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSLWN 586
            |.|.:..|:.:|..:|          :..|..|..:      :|:|....| ..|.|::::
Mouse   639 NLEMKRQRQSFLPCLRRGSLPKAQPCSEPRTPKRER------ASSPSPSSR-VCPATVIKS---- 692

  Fly   587 DDLKMWRIPESDLIKLPPATQKSGLHCIHPLVIHSENQHNNQN------------EIVVGEKVS 638
                  |:|..     |.|.|    :|..||.:.:.:.:...|            |.|..||||
Mouse   693 ------RVPLG-----PSALQ----NCSTPLALPTRDLNTTFNVSEESPSKPSFQEFVDWEKVS 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	136/359 (38%)
Kif18b	NP_932063.2	KISc_KIP3_like	18..353	CDD:276821	131/351 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..508		16/110 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	602..642		8/39 (21%)
		Nuclear localization signal. /evidence=ECO:0000250	619..627		3/7 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..686		5/37 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..834