Protein Alignment Kif3C and KIF9

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001400905.1
• Gene: KIF9 / 64147
• HGNCID: 16666
• Length: 823
• Species: Homo sapiens
• Alignment Length: 763
• Identity: 191/763 - (25%)
• Similarity: 305/763 - (39%)
• Gaps: 243/763 - (31%)

  Fly    54 VYNMKTD-------------TEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQG-DENF 104
            |.|.:||             .:::|:.:...:|...::||||||..|||||.|||:||.| .||:
Human    79 VNNQQTDWSFKLDGVLHDASQDLVYETVAKDVVSQALDGYNGTIMCYGQTGAGKTYTMMGATENY 143

  Fly   105 SNSTGIIPKCFDHIFERISMTTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGV 169
            .: .||:|:....:|..|...........|:|||||||.:.|||:             .||.:|
Human   144 KH-RGILPRALQQVFRMIEERPTHAITVRVSYLEIYNESLFDLLS-------------TLPYVG- 193

  Fly   170 SVPTLTTQPVVNANQ-----------------CYDWLHFGNKNRVTAATLMNKNSSRSHTIFTI- 216
              |::|...:|...|                 .:..|..|..||:.|:..|||||||||.||||
Human   194 --PSVTPMTIVENPQGVFIKGLSVHLTSQEEDAFSLLFEGETNRIIASHTMNKNSSRSHCIFTIY 256

  Fly   217 ------TLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALG 275
                  ||.:..::.|            |::|||||||||..|:|::|..||||:.||.|||.|.
Human   257 LEAHSRTLSEEKYITS------------KINLVDLAGSERLGKSGSEGQVLKEATYINKSLSFLE 309

  Fly   276 NVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNIS 340
            ..|.:|.|.|..|:|||..|||..|:||||||...::::.|.......:||:|:||:|||.|.::
Human   310 QAIIALGDQKRDHIPFRQCKLTHALKDSLGGNCNMVLVTNIYGEAAQLEETLSSLRFASRMKLVT 374

  Fly   341 NKPKINEDPKDARL-RQYQNEILYLKRMLQESQQIINKNNDPNKIIKSPLKIIQHTNMNS----- 399
            .:|.|||.....|: :..:.|:..||:.|.....:.|:    ..:...|:..||...:||
Human   375 TEPAINEKYDAERMVKNLEKELALLKQELAIHDSLTNR----TFVTYDPMDEIQIAEINSQVRRY 435

  Fly   400 ----TKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSKEEVQLQARSRIDLIKRS--------- 451
                ...:.||.| |..|..|.....:|:       |.::||:...|.:..||.|:
Human   436 LEGTLDEIDIISL-RQIKEVFNQFRVVLS-------QQEQEVESTLRRKYTLIDRNDFAAISAIQ 492

  Fly   452 ----------LIGGERIHDFEL-------------------KE--KHMARKYAA----------- 474
                      |:|.....:|.|                   ||  ..:|||..|
Human   493 KAGLVDVDGHLVGEPEGQNFGLGVAPFSTKPGKKAKSKKTFKEPLSSLARKEGASSPVNGKDLDY 557

  Fly   475 -----------------------QRHLSAI----------------------------------A 482
                                   .|..|:|                                  .
Human   558 VSTSKTQLVPSSKDGDVKDMLSRDRETSSIEPLPSDSPKEELRPIRPDTPPSKPVAFEEFKNEQG 622

  Fly   483 IALSRVKCEDRDLLQ----------GHYATITQEIDIKNDYIRKCK------------------E 519
            ..::|:..|::.:|.          .|...|.:|||:..:.:...|                  |
Human   623 SEINRIFKENKSILNERRKRASETTQHINAIKREIDVTKEALNFQKSLREKQGKYENKGLMIIDE 687

  Fly   520 KIKMLEMEVSDLNSEFQLDREDYLDEIRNLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSL 584
            :..:|.:::.||..::   |.:|.| :|:|..::::.|.|..:....           .:::..:
Human   688 EEFLLILKLKDLKKQY---RSEYQD-LRDLRAEIQYCQHLVDQCRHR-----------LLMEFDI 737

  Fly   585 WNDDLKMWRIPESDLIKLPP-ATQKSGLHCIHPLVIHSENQHNNQNEI 631
            |.::  .:.|||...:.|.| .:.:.|:..::.:|...|:..:..:::
Human   738 WYNE--SFVIPEDMQMALKPGGSIRPGMVPVNRIVSLGEDDQDKFSQL 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	120/322 (37%)
KIF9	NP_001400905.1	KISc_KIF9_like	39..371	CDD:276826	119/320 (37%)