Protein Alignment Kif3C and KIF13A

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_071396.4
• Gene: KIF13A / 63971
• HGNCID: 14566
• Length: 1805
• Species: Homo sapiens
• Alignment Length: 697
• Identity: 210/697 - (30%)
• Similarity: 327/697 - (46%)
• Gaps: 158/697 - (22%)

  Fly     1 MSE-NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQ------KKFIFDSVYNMK 58
            ||: .:||.||.||||:.|.|.|.:.:||: |...:|.:|....::|      |.|.||..:...
Human     1 MSDTKVKVAVRVRPMNRRELELNTKCVVEM-EGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSM 64

  Fly    59 TDT--------EVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCF 115
            .::        ||::..:...::|...:|||..||||||||.||:.:|.|   .:...|:||:..
Human    65 DESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMG---HAEQLGLIPRLC 126

  Fly   116 DHIFERISMTTN--VRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQP 178
            ..:|:|||:..|  ..:...|:|:|||||::||||:...:...:.  ::|...:|..|..|:...
Human   127 CALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLK--VREHKVLGPYVDGLSQLA 189

  Fly   179 VVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLV 243
            |.:.......:..|||:|..|||.||:.|||||.:|.|.:.|:.:....|:   .|....|:|||
Human   190 VTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGN---SGEKVSKVSLV 251

  Fly   244 DLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD-----GKAKHVPFRDSKLTRLLQDS 303
            |||||||..||||.|:||||.|.||.||:.||.|||||.|     ||:|.||:|||.||.||:|:
Human   252 DLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKSKFVPYRDSVLTWLLKDN 316

  Fly   304 LGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEI------- 361
            ||||::|.||:.|||...:|:||:||||||.|||.|.|...:||||....:|:.:.|:
Human   317 LGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQL 381

  Fly   362 --------LYLKRMLQESQQII------------------------------------------- 375
                    ..||..|:||:::|
Human   382 SQAEAMKAPELKEKLEESEKLIKELTVTWEEKLRKTEEIAQERQRQLESMGISLEMSGIKVGDDK 446

  Fly   376 ----NKNNDP--NKIIKSPLKIIQHTNM--NSTKNVQIIDLG---RNCKASFKTNNSILTKPNFP 429
                |.|.||  |:::...||  .||.:  ::::::|:..:|   ::|:....::..:...|
Human   447 CYLVNLNADPALNELLVYYLK--DHTRVGADTSQDIQLFGIGIQPQHCEIDIASDGDVTLTP--- 506

  Fly   430 LIQSKEEVQLQARSRIDLIKRSLIGGERI-----HDFELKEKHMARKYAAQRHLSAIAIALSRVK 489
                ||..:......:......|..|:||     |.|.                      ::..|
Human   507 ----KENARSCVNGTLVCSTTQLWHGDRILWGNNHFFR----------------------INLPK 545

  Fly   490 CEDRDLLQG---------HYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNSE------FQLDR 539
            .:.||.|:.         |......|...:.||    ..:...:|:.:..|||.      .|:..
Human   546 RKRRDWLKDFEKETGPPEHDLDAASEASSEPDY----NYEFAQMEVIMKTLNSNDPVQNVVQVLE 606

  Fly   540 EDYLDEIRNL--GRQVKFHQQL-FLKFSSNPGKFDRNWTPDTILQNS 583
            :.||:|.|:.  .:::.:.::| .|:...:|.:..::..||.:..:|
Human   607 KQYLEEKRSALEEQRLMYERELEQLRQQLSPDRQPQSSGPDRLAYSS 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	150/357 (42%)
KIF13A	NP_071396.4	KISc_KIF1A_KIF1B	5..359	CDD:276816	152/362 (42%)
		Kinesin_assoc	356..468	CDD:465047	19/113 (17%)
		FHA_KIF13A	446..554	CDD:438781	25/138 (18%)
		SMC_prok_B	<552..>770	CDD:274008	20/106 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	556..575		2/18 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	633..656		4/21 (19%)
		KIF1B	748..792	CDD:463574
		DUF3694	<1215..1279	CDD:463599
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1385..1404
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1507..1531
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1612..1645
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1749..1779