DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and kif26ab

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_005159017.1	Gene:	kif26ab / 58004	ZFINID:	ZDB-GENE-100716-6	Length:	2049	Species:	Danio rerio

Alignment Length:	746	Identity:	150/746 - (20%)
Similarity:	267/746 - (35%)	Gaps:	275/746 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IKVVVR-CRPMNQTEKERNCQNI-VEINEFAVSVTNPS-----------ARISQQKKFIFDSVYN 56
            :||::| |..:...:...:...: |::.:..:::.:||           |.:...|.|.||:|::
Zfish   403 VKVMMRICPSLGVVDSSESMSFLKVDMRKKQLTLYDPSLHTQPTSVHRRAVLPAPKMFAFDAVFS 467

  Fly    57 MKTDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFER 121
            .......:.......:::|.:.|.:|.||.:|....|||:||.|.::...|.||.|.....:|:.
Zfish   468 QDASQAEVCSGTVAEVIQSVVNGADGCIFCFGHVKVGKTYTMIGTDSSMQSLGIAPCAISWLFKL 532

  Fly   122 IS---MTTNVRYLALVTYLEIY--NERIRDLLN--------KNENTNVINHFLKELPGIGVSVPT 173
            |:   ..|..|:...|:.:|||  :|.::|||:        ..::..|   :|:|.|..|..:
Zfish   533 INERKEKTGTRFSVRVSAVEIYGKDESLQDLLSDVPTGSLQDGQSPGV---YLREDPICGTQL-- 592

  Fly   174 LTTQPVVNANQCYDWLHFGNK-----NRVTAATLMN------KNSSRSHTIFTITLEQSPFLNSI 227
                    .|||........|     :...||...|      ::...||.:||:.:.|.....|.
Zfish   593 --------QNQCELRAPTAEKAALFLDAAIAARSTNHPDADEEDRRNSHMLFTLHIYQYRMEKSG 649

  Fly   228 GSDAFGGICRGKLSLVDLAGSE----RQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAKH 288
            .....||  |.:|.|:||...|    :.|..|         ..:.|||:||||||.:|.:| |||
Zfish   650 KGGMSGG--RSRLHLIDLGSCEKVLCKSRDAG---------GGLCLSLTALGNVILALANG-AKH 702

  Fly   289 VPFRDSKLTRLLQDSLGG-NTKTLMISCISPTDIHYDETISTLRYASRAKNISNK---------- 342
            ||:||||||.||:||||. |.:|.||:.||.:..:|.|:::|::.|||...:..|
Zfish   703 VPYRDSKLTMLLRDSLGNINCRTTMIAHISDSPANYAESLTTIQLASRIHRMRKKKSKYASSSSG 767

  Fly   343 ------------------------------PKINEDPK-DARLRQYQNEILY------------- 363
                                          |....||. .:...|..:.::|
Zfish   768 GESSCDEGRIRRPPHLRPFHPRTVALDPDLPSFLSDPDYSSSSEQSCDTVIYVGPGGAAISDREL 832

  Fly   364 ---------------LKRM--------------------LQESQQIINKNNDPNKII-------- 385
                           |.|.                    |||..:.|:.:.:|...:
Zfish   833 SDNEGPPAFVPIIPSLNRKQRGKDGPVDRDHFKCNTFAELQERLECIDGSEEPTAFVVESGENSG 897

  Fly   386 ----------------------KSPLKI----------------------------IQHTNMNST 400
                                  |:|.|:                            ::|:.:.|.
Zfish   898 SSKMDHSANKLKEGSSCISVSPKTPTKVLSSTQDSISKKSISVTSKLPSSPKHKSKLEHSKLQSA 962

  Fly   401 --------------------KNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSK----------- 434
                                :.||:.:.|..|... |.:.:|:::.:.|:::.|
Zfish   963 ASDKDLRDMCENVCRTSADGEKVQMSESGSLCTTG-KQSKTIISQNSEPVVREKVFFNKKLPKPA 1026

  Fly   435 -------------EEVQLQARSRIDLI-----KRSLIGGERIHDFELKEKHMARKYAAQRHLSAI 481
                         .|.:.::.:|:..|     ||    |:.|.:..:|..|:..:...:...:.
Zfish  1027 PPPPQQRDYVTVGSETEEKSATRVPPIGMSHQKR----GDSIGNSAVKVHHLNPRTPGEMRSNL- 1086

  Fly   482 AIALSRVKCEDRDLLQGHYATITQEIDIKND 512
                 |.:|.::|:|: ...|:.|.:::..:
Zfish  1087 -----RERCMEKDILR-TTVTLKQPVELNGE 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	109/375 (29%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	107/370 (29%)
kif26ab	XP_005159017.1	KISc	402..752	CDD:276812	109/373 (29%)
kif26ab	XP_005159017.1	Kinesin	438..750	CDD:278646	102/336 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900