DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and KIF17

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_065867.2	Gene:	KIF17 / 57576	HGNCID:	19167	Length:	1029	Species:	Homo sapiens

Alignment Length:	925	Identity:	295/925 - (31%)
Similarity:	399/925 - (43%)	Gaps:	340/925 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SENIKVVVRCRPMNQTEKERNCQNIVEIN--EFAVSVTNPSARISQQKKFIFDSVYNMKTDTEVI 64
            ||.:|||||||||||.|:|..||.:|.::  .....:.||.|.....|:|.||..|::...||.|
Human     3 SEAVKVVVRCRPMNQRERELRCQPVVTVDCARAQCCIQNPGAADEPPKQFTFDGAYHVDHVTEQI 67

  Fly    65 YDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTTNVR 129
            |:|:.|.|||...||||||||||||||.||:.||||..:..:..||||:.|:|:||.:....|.:
Human    68 YNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPSQRGIIPRAFEHVFESVQCAENTK 132

  Fly   130 YLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGNK 194
            :|...:|||||||.:||||..:....:   .|||.|..||.|..|:...|.:..||...:..|.|
Human   133 FLVRASYLEIYNEDVRDLLGADTKQKL---ELKEHPEKGVYVKGLSMHTVHSVAQCEHIMETGWK 194

  Fly   195 NRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGD 259
            ||....|||||:|||||:||||::|.|. ::..|.|   .:..|||:||||||||||.||||.|:
Human   195 NRSVGYTLMNKDSSRSHSIFTISIEMSA-VDERGKD---HLRAGKLNLVDLAGSERQSKTGATGE 255

  Fly   260 RLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYD 324
            |||||::|||||||||||||:||||:.||||:|||||||||||||||||||||::|:||.|.:||
Human   256 RLKEATKINLSLSALGNVISALVDGRCKHVPYRDSKLTRLLQDSLGGNTKTLMVACLSPADNNYD 320

  Fly   325 ETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQESQQ------IINKNNDPN- 382
            ||:||||||:|||||.|||:||||||||.||:||.||..||.:|.:...      ::::...|:
Human   321 ETLSTLRYANRAKNIRNKPRINEDPKDALLREYQEEIKKLKAILTQQMSPSSLSALLSRQVPPDP 385

  Fly   383 -----KIIKSPLKIIQH--------------------------------------TNMNSTKNVQ 404
                 |::..|  :|||                                      |.|.::.:|:
Human   386 VQVEEKLLPQP--VIQHDVEAEKQLIREEYEERLARLKADYKAEQESRARLEEDITAMRNSYDVR 448

  Fly   405 I---------------------------------------------------------------- 405
            :
Human   449 LSTLEENLRKETEAVLQVGVLYKAEVMSRAEFASSAEYPPAFQYETVVKPKVFSTTDTLPSDDVS 513

  Fly   406 --------------------IDLG----------------------RNCKASFKTNNS------- 421
                                |.||                      .|.:.|..|..|
Human   514 KTQVSSRFAELPKVEPSKSEISLGSSESSSLEETSVSEAFPGPEEPSNVEVSMPTEESRSRYFLD 578

  Fly   422 ----------ILTKPNFPLIQSKEEVQLQ------------------------------------ 440
                      :|.:.|:...:..:||.||
Human   579 ECLGQEAAGHLLGEQNYLPQEEPQEVPLQGLLGLQDPFAEVEAKLARLSSTVARTDAPQADVPKV 643

  Fly   441 ---------------AR------------------------------------------------ 442
                           ||
Human   644 PVQVPAPTDLLEPSDARPEAEAADDFPPRPEVDLASEVALEVVRTAEPGVWLEAQAPVALVAQPE 708

  Fly   443 ----------------------------------SRIDLIKRSLIGGERIHDFELKEKHMARK-Y 472
                                              :|:.|:::.::|||:..:.:|||||..|| |
Human   709 PLPATAGVKRESVGMEVAVLTDDPLPVVDQQQVLARLQLLEQQVVGGEQAKNKDLKEKHKRRKRY 773

  Fly   473 AAQRHLSAIAIALSRVKCEDRD----LLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNS 533
            |.:|....:| ||..   .|.|    :|...|.:|.:|:..|:..:.|.:.|::..|:|:.||.|
Human   774 ADERRKQLVA-ALQN---SDEDSGDWVLLNVYDSIQEEVRAKSKLLEKMQRKLRAAEVEIKDLQS 834

  Fly   534 EFQLDREDYLDEIRNLGRQVKFHQQL------FLKFSSNPGKFDRNWTPDTILQNSLWNDDLKMW 592
            ||||::.|||..||...|.....|||      .::...|....::      ||:.|.|::|...|
Human   835 EFQLEKIDYLATIRRQERDSMLLQQLLEQVQPLIRRDCNYSNLEK------ILRESCWDEDNGFW 893

  Fly   593 RIPESDLIK--LPPA 605
            :||...:.|  ||.|
Human   894 KIPHPVITKTSLPVA 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	190/337 (56%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	185/330 (56%)
KIF17	NP_065867.2	Motor_domain	4..335	CDD:277568	190/337 (56%)
		Kinesin	11..335	CDD:278646	185/330 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..569		5/45 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	647..673		2/25 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	908..931		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	968..1029
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145371
Domainoid	1	1.000	133	1.000	Domainoid score	I5085
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5883
Inparanoid	1	1.050	486	1.000	Inparanoid score	I1446
Isobase	1	0.950	-	0	Normalized mean entropy	S2602
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	1	1.000	-	-		FOG0006941
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107365
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2703
SonicParanoid	1	1.000	-	-		X5033
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.840