DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif3C and kif13ba

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_005169924.1	Gene:	kif13ba / 571520	ZFINID:	ZDB-GENE-070521-1	Length:	1822	Species:	Danio rerio

Alignment Length:	747	Identity:	222/747 - (29%)
Similarity:	340/747 - (45%)	Gaps:	176/747 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEI--NE---FAVSVTNPSARISQQKKFIFD-SVYNM-KTDT 61
            |:||.||.||||:.||:.|.:.:||:  |:   ::.::...|:| .|.|.|.:| ..::| :::|
Zfish    10 NVKVAVRVRPMNRREKDLNTKCVVEMEGNQTFLYSTNLGKDSSR-GQPKTFAYDYCFWSMDESET 73

  Fly    62 E------VIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFE 120
            |      |::..:..||:.:..:|||..||||||||.||::||.|.   .:..|:||:....:||
Zfish    74 EKFAGQDVVFQCLGESLLHNAFQGYNACIFAYGQTGSGKSYTMMGS---VDQPGLIPRLCSSLFE 135

  Fly   121 R--ISMTTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNAN 183
            |  :.......:...|:|:|||||::||||:...:...:.  ::|...:|..|..|:...|.:..
Zfish   136 RTVLHQREEESFTVEVSYMEIYNEKVRDLLDPKGSRQALR--VREHKVLGPYVDGLSRLAVESYK 198

  Fly   184 QCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGS 248
            .....:..|||:|..|||.||:.|||||.:|.|.|..:  |..:.|...|... .||||||||||
Zfish   199 DIESLMSEGNKSRTVAATNMNEESSRSHAVFNIILTHT--LKDLQSGTSGEKV-SKLSLVDLAGS 260

  Fly   249 ERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD-----GKAKHVPFRDSKLTRLLQDSLGGNT 308
            ||..||||.|:||||.|.||.||:.||.|||:|.|     .|.|.||:|||.||.||:||||||:
Zfish   261 ERAAKTGAAGERLKEGSNINKSLTTLGLVISALADQGAGKNKNKFVPYRDSVLTWLLKDSLGGNS 325

  Fly   309 KTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEI------------ 361
            :|.|::.:||...:||||:||||||.|||:|.|...:||||....:|:.:.|:
Zfish   326 RTAMVATVSPAADNYDETLSTLRYADRAKSIVNHAVVNEDPNARIIRELREEVEKLRDQLTQAES 390

  Fly   362 ---LYLKRMLQESQQII-----------------------------------------------N 376
               ..||..|:||:::|                                               |
Zfish   391 MKAPELKERLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQSSGIKVGEDKCFLVN 455

  Fly   377 KNNDP--NKIIKSPLKIIQHTNMNS--TKNVQIIDLG---RNCKASFKTNNSILTKP-------- 426
            .|.||  |:::...||  :||.:.|  ::::|:..:|   .:|..:.....::...|
Zfish   456 LNADPALNELLVYYLK--EHTKVGSADSQDIQLCGMGIQAEHCVINITPEGAVFINPYRNSRTCV 518

  Fly   427 NFPLIQSKEEVQLQAR--------SRIDLIKRSLIGGERIHDFELKEKHMARKYAAQRHLSAIAI 483
            |...:.|::::....|        .||:|.||.|.|.|     |..|....:...:...|.....
Zfish   519 NGSPVTSRQQLHHGDRILWGNNHFFRINLPKRRLRGEE-----EEGEGGNMKSSNSNEQLDGEGD 578

  Fly   484 ALSRVKCEDRDLLQGHYATITQEIDIK----NDYIRKCKEKIKMLEMEVSDLNSEFQLDREDYLD 544
            ..|.|..|    :...|.....|:.:|    ||.::...:.::....|  :..:..:..|..|..
Zfish   579 TASEVSSE----VSFSYEFAQTEVMMKALGSNDPMQAVLQSLERQHEE--EKRTALERQRLMYEQ 637

  Fly   545 EIRNLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSLWNDDLKMWRIPES--------DLIK 601
            |::.|.||:                     |||.           :..:||:|        .:.:
Zfish   638 ELQQLRRQL---------------------TPDR-----------QSMQIPQSQPLQPHYRSMER 670

  Fly   602 LPPATQKSGLHCIHPLVIHSENQHNNQNEIVV 633
            |......|.....|.|     .|.:.:.|:|:
Zfish   671 LSQGGMSSSSSAQHRL-----RQWSEEREVVL 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	152/354 (43%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	148/348 (43%)
kif13ba	XP_005169924.1	KISc_KIF1A_KIF1B	9..363	CDD:276816	154/361 (43%)
		KISc	10..363	CDD:214526	154/361 (43%)
		Kinesin_assoc	360..472	CDD:292801	19/113 (17%)
		FHA	450..547	CDD:238017	19/98 (19%)
		KIF1B	774..820	CDD:289208
		DUF3585	<1100..1161	CDD:304905
		DUF3694	<1239..1297	CDD:289256
		CAP_GLY	1718..1781	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910