DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif3C and kif17

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001373250.1	Gene:	kif17 / 557863	ZFINID:	ZDB-GENE-080724-12	Length:	823	Species:	Danio rerio

Alignment Length:	712	Identity:	271/712 - (38%)
Similarity:	395/712 - (55%)	Gaps:	117/712 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SENIKVVVRCRPMNQTEKERNCQNIVEINEFAVS--VTNPSARISQQKKFIFDSVYNMKTDTEVI 64
            ||::||||||||:|..||..||:.:|.::.....  :..|.......|:|.||..|.:...||.:
Zfish     3 SESVKVVVRCRPLNNREKAMNCKIVVSVDSTHCQCFIKKPGDTEEPPKQFTFDGTYYINHSTEEV 67

  Fly    65 YDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTTNVR 129
            |:|:.|.|||...||||||||||||||.||:.||||..:..:..||||:.|:||||.|....|.:
Zfish    68 YNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGVPDPPSQRGIIPRAFEHIFETIQCAENTK 132

  Fly   130 YLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFGNK 194
            :|...:|||||.|.|||||.|:....:   .|||.|..||.|..||.|.|.:..:|...:..|.:
Zfish   133 FLVRASYLEIYKEEIRDLLGKDIKQKM---ELKEHPERGVYVRDLTMQTVHSVGECERVMDLGWR 194

  Fly   195 NRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGD 259
            ||....|||||:|||||:||||.||    :.||.:.....:..|||:||||||||||.||||.||
Zfish   195 NRSVGYTLMNKDSSRSHSIFTIHLE----ICSIDTAGDEHLRAGKLNLVDLAGSERQSKTGATGD 255

  Fly   260 RLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYD 324
            ||:||::|||||||||||||:||||::|::|:|||||||||||||||||:|||::|:||.|.:|:
Zfish   256 RLQEATKINLSLSALGNVISALVDGRSKYIPYRDSKLTRLLQDSLGGNTRTLMVACLSPADNNYE 320

  Fly   325 ETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQ------------------ES 371
            |:|||||||:|||:|.|:|:||||||||.||:||.||..|:.::.                  |:
Zfish   321 ESISTLRYANRAKSIQNRPRINEDPKDALLREYQEEIKKLRALISGQLGSGNLSSFLAGQKSGEA 385

  Fly   372 QQIINK---NNDPNKIIKSPLK---------------IIQHTNMNSTKNVQIIDLGRNCKASFKT 418
            ..::::   |...::..|..:|               ..|.:.:...:::..:      :.|::|
Zfish   386 SAVVSRPQSNTSESEAEKDKIKEEYEKKLARLQAEYDAEQESKVKLQEDIAAL------RTSYET 444

  Fly   419 NNSIL---------TKPNFPLIQSKEE-------VQLQAR------------------------- 442
            ..|.|         |.....|.|.|||       .|.||:
Zfish   445 RLSSLERSRGSRTHTTGGVHLQQHKEEPITASAASQEQAKIDHSESEERPSSVDATVKGAASGES 509

  Fly   443 --------------------SRIDLIKRSLIGGERIHDFELKEKHMARKYAAQRHLSAIAIALSR 487
                                .|:..:::..:|||::.:.|||::|..||..|.:....:..||::
Zfish   510 QILDSVVVDIPGQLDQKLALERLQQLEQEFVGGEQVRNEELKQRHKQRKTLADQRKKQLIEALNQ 574

  Fly   488 VKCEDRD-LLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDREDYLDEIRNLGR 551
             ..||.| :|...|.:|.:|:..|:.::...::|:|..::|:.||.:||:::|.|||..||.|.|
Zfish   575 -SSEDGDSVLLNVYDSIQEEVHAKSRHLENTQKKLKAAKLEIRDLQAEFEMERNDYLATIRRLER 638

  Fly   552 QVKFHQQLFLKFSSNPGKFDRNWTP-DTILQNSLWNDDLKMWRIPESDLIKLP-PATQKSGL 611
            :.:..|.:..:..|...: |.|::. |.:.:.::|:::...||:|:..:.|.. ||...||:
Zfish   639 EGQLLQGILERMVSLVRR-DCNYSNLDRLRKEAVWDEEGGTWRLPDVLVQKTTLPAVPPSGV 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	184/337 (55%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	179/330 (54%)
kif17	NP_001373250.1	Motor_domain	4..335	CDD:419868	184/337 (55%)
kif17	NP_001373250.1	Smc	395..>650	CDD:224117	54/261 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578634
Domainoid	1	1.000	126	1.000	Domainoid score	I5366
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5883
Inparanoid	1	1.050	466	1.000	Inparanoid score	I1509
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	1	1.000	-	-		FOG0006941
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107365
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2703
SonicParanoid	1	1.000	-	-		X5033
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790