Protein Alignment Kif3C and KIF16B

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_005260807.1
• Gene: KIF16B / 55614
• HGNCID: 15869
• Length: 1883
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 215/632 - (34%)
• Similarity: 311/632 - (49%)
• Gaps: 102/632 - (16%)

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTN---------PSARISQQKKFIFD-SVYNMK 58
            ::||.||.||||:.||:...:.|:::.:...::||         .|.| .:.|.|.:| |.|:..
Human     3 SVKVAVRVRPMNRREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGR-ERTKTFTYDFSFYSAD 66

  Fly    59 TDT------EVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDH 117
            |.:      |:::..:...:|:|..||||..:|||||||.||::||.|:   |..:|:||:..:.
Human    67 TKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGN---SGDSGLIPRICEG 128

  Fly   118 IFERISMTT---NVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPV 179
            :|.||:.||   ...:...|:||||||||:|||| :.:::...|..::|.|..|..|..|:...|
Human   129 LFSRINETTRWDEASFRTEVSYLEIYNERVRDLL-RRKSSKTFNLRVREHPKEGPYVEDLSKHLV 192

  Fly   180 VNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVD 244
            .|.....:.:..||.||.||||.||..|||||.||||...|:.|.:.:..:..     .|:.|||
Human   193 QNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKFDSEMPCETV-----SKIHLVD 252

  Fly   245 LAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD---------GKAKH--VPFRDSKLTR 298
            ||||||...|||.|.||||...||.||..||||||:|.|         .|.|.  ||:|||.||.
Human   253 LAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTLAKKKQVFVPYRDSVLTW 317

  Fly   299 LLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILY 363
            ||:||||||:||:||:.|||.|::|.||:||||||:|||||.|||.||||.....:|:.:.||..
Human   318 LLKDSLGGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIAR 382

  Fly   364 LKRMLQESQQIINKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNF 428
            ||.:|.:..||        .::.||..:.....:...: .::.:|.:.....:....:||.:...
Human   383 LKTLLAQGNQI--------ALLDSPTALSMEEKLQQNE-ARVQELTKEWTNKWNETQNILKEQTL 438

  Fly   429 PLIQSKEEVQLQARSRI--------DLIKRSLI-----GGER--------------IHDFELKEK 466
            .|  .||.:.:...|.:        ||:...:|     .|:.              :|..:|:.:
Human   439 AL--RKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGRDDASTEQDIVLHGLDLESE 501

  Fly   467 HMARKYAAQRHLSAIAIALSRVKC--------EDRDLLQGHYATITQEIDIKNDYIRKCKEKIKM 523
            |...:....   :...|.||..:|        |...|.||....:.:....:.::   .||..|:
Human   502 HCIFENIGG---TVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFRFNH---PKEAAKL 560

  Fly   524 LEMEVSDLNSEFQLDREDYLDEIRNLGRQVKFHQQLFLKFSSNPGKF 570
            .|...|.|.|.|.|...|......||...:.:          |||.|
Human   561 REKRKSGLLSSFSLSMTDLSKSRENLSAVMLY----------NPGLF 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	158/364 (43%)
KIF16B	XP_005260807.1	KISc_KIF1A_KIF1B	2..365	CDD:276816	163/371 (44%)
		Kinesin_assoc	364..476	CDD:465047	24/122 (20%)
		FHA_KIF16B	446..562	CDD:438784	19/121 (16%)
		Smc	<606..>1089	CDD:440809