DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and KIF21A

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001365368.1	Gene:	KIF21A / 55605	HGNCID:	19349	Length:	1675	Species:	Homo sapiens

Alignment Length:	797	Identity:	226/797 - (28%)
Similarity:	347/797 - (43%)	Gaps:	222/797 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVT--NPSARISQQKKFIFDSVYNMKTDTEVIYD 66
            :::|.||.||....||...|       ....|||  .|...:.:.|.|.||.|:::.:..|.||.
Human     9 SVRVAVRIRPQLAKEKIEGC-------HICTSVTPGEPQVFLGKDKAFTFDYVFDIDSQQEQIYI 66

  Fly    67 EMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQG--DENF-SNSTGIIPKCFDHIFERISMTTNV 128
            :....|:|...||||.|:|||||||.|||:||..  |.|. ....|||.:...|:|:.|.   ..
Human    67 QCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIVEEELGIISRAVKHLFKSIE---EK 128

  Fly   129 RYLAL------------VTYLEIYNERIRDLLN-------KNENTNVINHFLKELPGIGVSVPTL 174
            :::|:            ..:||:|||.:.||.:       |::.:|:..|  ::..| |:....:
Human   129 KHIAIKNGLPAPDFKVNAQFLELYNEEVLDLFDTTRDIDAKSKKSNIRIH--EDSTG-GIYTVGV 190

  Fly   175 TTQPVVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSD--------- 230
            ||:.|...::....|..|..:|.||:|.||..|||||.||||.:.|:.....|.:|
Human   191 TTRTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQIDADNATDNKIIS 255

  Fly   231 ------AFGGICRGKLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD--GKAK 287
                  .|..: ..|...||||||||.::|||.|:|.||...||..|.|||||||:|.|  .:|.
Human   256 ESAQMNEFETL-TAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSKRAT 319

  Fly   288 HVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDA 352
            |||:||||||||||||||||::|:||:|:||:|..:.||::||:||:||:||.||..:|:|....
Human   320 HVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQDRASQ 384

  Fly   353 RLRQYQNEILYLKRMLQE---SQQIINKN-----ND----------PNKIIKSPLKIIQHT---- 395
            ::...::||..|:..|.|   .::||::.     ||          .|..::..:|.:|.|
Human   385 QINALRSEITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQTENNNLRVRIKAMQETVDAL 449

  Fly   396 ---------------------------NMNSTKNVQIIDLGRNCKASFKTNNSI---LTK----- 425
                                       ||..:...:|.||......|...|.::   ||:
Human   450 RSRITQLVSDQANHVLARAGEGNEEISNMIHSYIKEIEDLRAKLLESEAVNENLRKNLTRATARA 514

  Fly   426 PNF-------PLIQS--KEEVQLQARSRIDLIK----------------------RSLIGGERIH 459
            |.|       |.|.|  ||.:::...::.||.|                      ||:.|.|...
Human   515 PYFSGSSTFSPTILSSDKETIEIIDLAKKDLEKLKRKEKRKKKRLQKLEESNREERSVAGKEDNT 579

  Fly   460 DFELKEKHMARKYAAQRHLSAIAIALSR-----------------------------VKCEDRDL 495
            |.:.::|.  .|..::|..:.:.:..|:                             .:.:::..
Human   580 DTDQEKKE--EKGVSERENNELEVEESQEVSDHEDEEEEEEEEEDDIDGGESSDESDSESDEKAN 642

  Fly   496 LQGHYATITQEIDIKNDYI--------------RKCKEKIKMLEMEVSDLNSEFQLDREDYLDEI 546
            .|...|.||.||.||...|              ::.:||:.||:.::.|.    ||:|:..|
Human   643 YQADLANITCEIAIKQKLIDELENSQKRLQTLKKQYEEKLMMLQHKIRDT----QLERDQVL--- 700

  Fly   547 RNLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSLWNDDLKMWRIPESDLIKLPPATQKSGL 611
            :|||....:.::...|..|...|           :....|.:|:..:           |.||.
Human   701 QNLGSVESYSEEKAKKVRSEYEK-----------KLQAMNKELQRLQ-----------AAQKE-- 741

  Fly   612 HCIHPLVIHSENQHNNQ 628
               |..::.:::|:..|
Human   742 ---HARLLKNQSQYEKQ 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	147/375 (39%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	145/369 (39%)
KIF21A	NP_001365368.1	KISc_KIF4	8..372	CDD:276823	148/376 (39%)
		Cast	<364..836	CDD:401982	83/428 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..641		9/86 (10%)
		Smc	<644..1004	CDD:224117	32/146 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..804
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	841..881
		Rcc_KIF21A	936..1017	CDD:410204
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1116..1138
		Interaction with KANK1 and KANK2. /evidence=ECO:0000269\|PubMed:29183992	1146..1167
		WD40	1340..1653	CDD:238121
		WD 1	1346..1383
		WD 2	1386..1424
		WD40 repeat	1391..1450	CDD:293791
		WD 3	1450..1488
		WD40 repeat	1456..1491	CDD:293791
		WD 4	1491..1533
		WD40 repeat	1496..1540	CDD:293791
		WD 5	1542..1579
		WD40 repeat	1548..1581	CDD:293791
		WD 6	1583..1622
		WD40 repeat	1588..1624	CDD:293791
		WD 7	1625..1662
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910