Protein Alignment Kif3C and kif3a

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_001017604.2
• Gene: kif3a / 550267
• ZFINID: ZDB-GENE-050417-71
• Length: 701
• Species: Danio rerio
• Alignment Length: 697
• Identity: 263/697 - (37%)
• Similarity: 370/697 - (53%)
• Gaps: 120/697 - (17%)

  Fly     1 MSENIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQ--KKFIFDSVYNMKTDTEV 63
            :|:|:||||||||:|:.||....:..|.::|...::|.....||.:  |.|.||:|:...:....
Zfish    14 VSDNVKVVVRCRPLNEKEKIMGHKQSVTVDEIRGTITVNKLDISSEPPKTFTFDTVFGPDSKQLD 78

  Fly    64 IYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTT-N 127
            :|:.....:::|.:||||||||||||||.|||.||:|........||||..|.|:|..|:... :
Zfish    79 VYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPELRGIIPNSFAHVFGHIAKAEGD 143

  Fly   128 VRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFG 192
            .|:|..|:|||||||.:||||.|::...:   .:||.|.:||.:..|:...|.||:.....:..|
Zfish   144 TRFLVRVSYLEIYNEEVRDLLGKDQMQRL---EVKERPDVGVYIKDLSGYVVNNADDMDRIMTLG 205

  Fly   193 NKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQ 257
            :|||...||.||::|||||.|||||:|.|    ..|.|....:..|||.||||||||||.||||.
Zfish   206 HKNRSVGATNMNEHSSRSHAIFTITIECS----EKGVDGNQHVRMGKLHLVDLAGSERQGKTGAT 266

  Fly   258 GDRLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIH 322
            |.|||||::||||||.||||||:|||||:.|||:|:||||||||||||||:||:|.:.|.|.|.:
Zfish   267 GQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYN 331

  Fly   323 YDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQESQQII------------ 375
            |||||||||||:|||||.||.:||||||||.|||:|.||..||:.|:|.::|.
Zfish   332 YDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDGSGSDDMDE 396

  Fly   376 ---------------NKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTK 425
                           .|...|:|:::...||.:.......| :.:.:..|| ||     .:.|.|
Zfish   397 DDVGDGGERRRKRRGRKKVSPDKMVEMQAKIEEERKALEAK-LDMEEEERN-KA-----RAELEK 454

  Fly   426 PNFPLIQSKEEVQLQARSRIDLIKRSLIGG----------ERIHDFELKEKHMARKYAAQ--RHL 478
            ....|:::::|..|.......|.||.::||          |::.:....|....||.|.|  |.|
Zfish   455 REKDLLKAQQEHHLLLEKLSALEKRVIVGGVDLLAKAEEQEKLLEESNNELEERRKRAEQLRREL 519

  Fly   479 SAIAIALSRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDREDYL 543
            ..        |.::|..::..|.::.:|...|...::|....:...:.|::||..|...:.|..|
Zfish   520 EE--------KEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHHREIEGLL 576

  Fly   544 DEIRNLGRQVKFHQQLFLKFSSNPGKFDRNWTP---DTILQNSL-WNDDLKMWRI---------- 594
            :.||.|.|:::. |.|.:.          |:.|   ..:::|.: ||:|:..|::
Zfish   577 ENIRQLSRELRL-QMLIID----------NFIPQEYQEMIENYVHWNEDIGEWQLKCVAYTGNNM 630

  Fly   595 ----PESD--------------------------LIKLP-PATQKSG 610
                |.||                          |:||. |.|.|:|
Zfish   631 RKQTPVSDKKEKDPFEVDLSHVYLAYTEESMRQSLMKLERPRTSKNG 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	176/338 (52%)
kif3a	NP_001017604.2	KISc_KIF3	16..348	CDD:276822	176/338 (52%)
		Smc	<424..>589	CDD:440809	41/180 (23%)