DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and kif3a

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001017604.2	Gene:	kif3a / 550267	ZFINID:	ZDB-GENE-050417-71	Length:	701	Species:	Danio rerio

Alignment Length:	697	Identity:	263/697 - (37%)
Similarity:	370/697 - (53%)	Gaps:	120/697 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSENIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQ--KKFIFDSVYNMKTDTEV 63
            :|:|:||||||||:|:.||....:..|.::|...::|.....||.:  |.|.||:|:...:....
Zfish    14 VSDNVKVVVRCRPLNEKEKIMGHKQSVTVDEIRGTITVNKLDISSEPPKTFTFDTVFGPDSKQLD 78

  Fly    64 IYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMTT-N 127
            :|:.....:::|.:||||||||||||||.|||.||:|........||||..|.|:|..|:... :
Zfish    79 VYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPELRGIIPNSFAHVFGHIAKAEGD 143

  Fly   128 VRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFG 192
            .|:|..|:|||||||.:||||.|::...:   .:||.|.:||.:..|:...|.||:.....:..|
Zfish   144 TRFLVRVSYLEIYNEEVRDLLGKDQMQRL---EVKERPDVGVYIKDLSGYVVNNADDMDRIMTLG 205

  Fly   193 NKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQ 257
            :|||...||.||::|||||.|||||:|.|    ..|.|....:..|||.||||||||||.||||.
Zfish   206 HKNRSVGATNMNEHSSRSHAIFTITIECS----EKGVDGNQHVRMGKLHLVDLAGSERQGKTGAT 266

  Fly   258 GDRLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTDIH 322
            |.|||||::||||||.||||||:|||||:.|||:|:||||||||||||||:||:|.:.|.|.|.:
Zfish   267 GQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYN 331

  Fly   323 YDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRMLQESQQII------------ 375
            |||||||||||:|||||.||.:||||||||.|||:|.||..||:.|:|.::|.
Zfish   332 YDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEISGSDGSGSDDMDE 396

  Fly   376 ---------------NKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTK 425
                           .|...|:|:::...||.:.......| :.:.:..|| ||     .:.|.|
Zfish   397 DDVGDGGERRRKRRGRKKVSPDKMVEMQAKIEEERKALEAK-LDMEEEERN-KA-----RAELEK 454

  Fly   426 PNFPLIQSKEEVQLQARSRIDLIKRSLIGG----------ERIHDFELKEKHMARKYAAQ--RHL 478
            ....|:::::|..|.......|.||.::||          |::.:....|....||.|.|  |.|
Zfish   455 REKDLLKAQQEHHLLLEKLSALEKRVIVGGVDLLAKAEEQEKLLEESNNELEERRKRAEQLRREL 519

  Fly   479 SAIAIALSRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDREDYL 543
            ..        |.::|..::..|.::.:|...|...::|....:...:.|::||..|...:.|..|
Zfish   520 EE--------KEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHHREIEGLL 576

  Fly   544 DEIRNLGRQVKFHQQLFLKFSSNPGKFDRNWTP---DTILQNSL-WNDDLKMWRI---------- 594
            :.||.|.|:::. |.|.:.          |:.|   ..:::|.: ||:|:..|::
Zfish   577 ENIRQLSRELRL-QMLIID----------NFIPQEYQEMIENYVHWNEDIGEWQLKCVAYTGNNM 630

  Fly   595 ----PESD--------------------------LIKLP-PATQKSG 610
                |.||                          |:||. |.|.|:|
Zfish   631 RKQTPVSDKKEKDPFEVDLSHVYLAYTEESMRQSLMKLERPRTSKNG 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	176/338 (52%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	171/331 (52%)
kif3a	NP_001017604.2	KISc_KIF3	16..348	CDD:276822	176/338 (52%)
kif3a	NP_001017604.2	Kinesin	23..348	CDD:278646	171/331 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145782at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820