Protein Alignment Kif3C and KIF1A

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: XP_047300774.1
• Gene: KIF1A / 547
• HGNCID: 888
• Length: 1825
• Species: Homo sapiens
• Alignment Length: 781
• Identity: 219/781 - (28%)
• Similarity: 330/781 - (42%)
• Gaps: 219/781 - (28%)

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTE------ 62
            ::||.||.||.|..|..|:.:.|::::....::.||.......|.|.||..|...|..|
Human     5 SVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYAS 69

  Fly    63 --VIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMT 125
              .:|.::...:::...||||..||||||||.||::||.|.:. .:..||||:..:.:|.||:.|
Human    70 QKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQE-KDQQGIIPQLCEDLFSRINDT 133

  Fly   126 T--NVRYLALVTYLEIYNERIRDLLN-KNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYD 187
            |  |:.|...|:|:|||.||:||||| ||:.    |..::|.|.:|..|..|:...|.:.|...|
Human   134 TNDNMSYSVEVSYMEIYCERVRDLLNPKNKG----NLRVREHPLLGPYVEDLSKLAVTSYNDIQD 194

  Fly   188 WLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICR---GKLSLVDLAGSE 249
            .:..|||.|..|||.||:.|||||.:|.|...|.      ..||...|..   .|:|||||||||
Human   195 LMDSGNKARTVAATNMNETSSRSHAVFNIIFTQK------RHDAETNITTEKVSKISLVDLAGSE 253

  Fly   250 RQRKTGAQGDRLKEASQINLSLSALGNVISSLVD-----------GKAKHVPFRDSKLTRLLQDS 303
            |...|||:|.||||.:.||.||:.||.|||:|.:           .|...:|:|||.||.||:::
Human   254 RADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLREN 318

  Fly   304 LGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRML 368
            ||||::|.|::.:||.||:||||:||||||.|||.|.....|||||.:..:|:.::|:..|:.:|
Human   319 LGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNKLIRELKDEVTRLRDLL 383

  Fly   369 QESQQIINKNNDPNKIIKSPLKI--IQHTNMN------------STKNVQIIDLGRNCKAS---- 415
            .  .|.:....|.|.:...|..:  :::.|:|            ||....::.:..:...|
Human   384 Y--AQGLGDITDTNTVPGGPKYVSDLENNNLNRGGTVNEAPDPLSTVTNALVGMSPSSSLSALSS 446

  Fly   416 ------------------------FKTNNSILTKPN----------------------------- 427
                                    .|....|:.:.|
Human   447 RAASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMR 511

  Fly   428 -------------FPLIQSKEEVQLQARSRIDLIKRSL--IG---GERIHDFEL-----KEKHM- 468
                         .|.:.:..|..|.:...:..||..:  :|   |||..|..|     ||:|.
Human   512 EDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEHCV 576

  Fly   469 --------------------ARKYAAQRHLSAIAIALS-------------------------RV 488
                                |..|...:.::..:|..|                         |.
Human   577 FRSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERT 641

  Fly   489 KCED------------RDLLQGHYATITQEI-----DIKNDYIRKCKEKIKMLEMEVSDLNSEF- 535
            .|.:            |:||:.....:.||:     ::::.|.|:.:|...:||.:..|..|:.
Human   642 PCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLE 706

  Fly   536 ----QLD----------REDYLDEIRNLGRQVKFHQQLFLKFSSNPGKFDRNWTPDTILQNSLWN 586
                |:|          .|:..||::...|:.:.....|.|:         .|...|.|::.||.
Human   707 ALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKW---------KWYQFTSLRDLLWG 762

  Fly   587 D 587
            :
Human   763 N 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	152/359 (42%)
KIF1A	XP_047300774.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	153/366 (42%)
		Kinesin_assoc	358..549	CDD:465047	26/192 (14%)
		FHA_KIF1A	525..639	CDD:438778	18/113 (16%)
		ERM_helical	658..>711	CDD:466641	12/52 (23%)
		KIF1B	839..886	CDD:463574
		DUF3694	1275..1431	CDD:463599
		PH_KIFIA_KIFIB	1706..1808	CDD:269939