DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and Kif9

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_006244056.1	Gene:	Kif9 / 501059	RGDID:	1565187	Length:	860	Species:	Rattus norvegicus

Alignment Length:	744	Identity:	193/744 - (25%)
Similarity:	296/744 - (39%)	Gaps:	245/744 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ENIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTD------- 60
            :.::..||.:|.:....|     :::..|     .|.|..|..:|.....:|.|.:||
  Rat    75 KKVQAFVRVKPTDDFAHE-----MIKYGE-----DNKSIDIHLKKDTRRGAVNNQQTDWSFKLDG 129

  Fly    61 ------TEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQG-DENFSNSTGIIPKCFDHI 118
                  .:::|:.:....|...::||||||..|||||.|||:||.| .||:.: .||:|:....:
  Rat   130 VLHDASQDLVYETVAKDAVSQALDGYNGTIMCYGQTGAGKTYTMTGATENYKH-RGILPRALQQV 193

  Fly   119 FERISMTTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNAN 183
            |..|...........|:|||||||.:.|||:             .||.:|   |::|...:|...
  Rat   194 FRMIEERPTHAITVRVSYLEIYNENLFDLLS-------------TLPYVG---PSVTPMTIVENP 242

  Fly   184 Q-----------------CYDWLHFGNKNRVTAATLMNKNSSRSHTIFTI-------TLEQSPFL 224
            |                 .:..|..|..||:.|:..|||||||||.||||       ||....::
  Rat   243 QGVFIKGLSVHLTSQEEDAFSLLFEGETNRIIASHTMNKNSSRSHCIFTIYMEAHSRTLSDEKYI 307

  Fly   225 NSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAKHV 289
            .|            |::|||||||||..|||::|..||||:.||.|||.|...|.:|.|....|:
  Rat   308 TS------------KINLVDLAGSERLSKTGSEGRVLKEATYINKSLSFLEQAIIALGDQNRDHI 360

  Fly   290 PFRDSKLTRLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARL 354
            |||.||||..|:||||||...::::.|.......|||:|:||:|||.|.::.:|.|||.....|:
  Rat   361 PFRQSKLTHALKDSLGGNCNMVLVTNIYGEAAQLDETLSSLRFASRMKLVTTEPAINEKYDAERM 425

  Fly   355 -RQYQNEILYLKRMLQESQQIINK---NNDPNKIIKSPLKIIQHTNMNS---------TKNVQII 406
             :..:.|:..||:.|.....:.|:   |.|       |:..||...:||         ...:.||
  Rat   426 VKNLEKELALLKQELAIHDSLSNRTLVNYD-------PMDEIQIAEINSQVRRYLEGTLDEIDII 483

  Fly   407 DLGRNCKASFKTNNSILTKPNFPLIQSKEEVQLQARSRIDLIKRS-------------------L 452
            :| |..:..|.....:|:       |.::||:...|.:..||.::                   |
  Rat   484 NL-RQIQEVFNQFRVVLS-------QQEQEVESALRRKYTLIDKNDFAAISAVQKAGLMDVEGHL 540

  Fly   453 IG-------GERIHDFELKE--------------KHMARKYAA---------------------- 474
            :|       |..:..|.:|.              ...|||..|
  Rat   541 VGEPDGQSFGLGVAPFSVKPGKKSKTKKTTKDQFSSSARKEGASSPVSGKDFDMTSISKTQLIPS 605

  Fly   475 ------------QRHLSAI----------------------------------AIALSRVKCEDR 493
                        :|..|:|                                  ...::|:..|::
  Rat   606 SKEGDLKDMLVRERETSSIEPLPSDSPKEESRALRPSTPPSKPVAFEEFKNERGSEINRIFKENK 670

  Fly   494 DLLQ----------GHYATITQEIDI--------------KNDYIRK----CKEKIKMLEMEVSD 530
            .:|.          .....|.||||:              :.:|..|    ..|:..:|.:::.|
  Rat   671 SILNERKKRASETTQRINAIKQEIDVTKEALNFQKSLREKQGEYENKGLMIIDEEEFLLILKLKD 735

  Fly   531 LNSEFQLDREDYLDEIRNLGRQVKFHQQL 559
            |..::   |.:| .|:|:|..::::.|:|
  Rat   736 LKKQY---RNEY-QELRDLRAEIQYCQRL 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	131/373 (35%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	130/366 (36%)
Kif9	XP_006244056.1	KISc_KIF9_like	76..408	CDD:276826	130/370 (35%)
Kif9	XP_006244056.1	Kinesin	82..410	CDD:278646	130/366 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810