DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and Klp54D

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	182/567 - (32%)
Similarity:	263/567 - (46%)	Gaps:	120/567 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ENIKVVVRCRPMNQTEKE----------RNCQNIVEINEFAV--SVTNPSARISQQKKFIFDSVY 55
            :||.||||.||:|..||.          .|.|.|:|.|:...  |....|.|:     |.::.|:
  Fly   165 DNINVVVRVRPLNDKEKRDRHGSTLQFPGNGQVILEGNDVGQKRSHNRDSVRV-----FTYNVVF 224

  Fly    56 NMKTDTEVIYDEMCYS----LVESTIEGYNGTIFAYGQTGCGKTHTMQGDENF--------SNST 108
            ......|.|.|   ||    ::|..|||::.|.|.|||||.|||||:.|..:.        ....
  Fly   225 EPGATQEDILD---YSGIKRIIEMGIEGFSCTAFCYGQTGSGKTHTLTGPPDLFVGKPNPKDPRH 286

  Fly   109 GIIPKCFDHIFERISMTTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPT 173
            |:|.:.|.::|:.|....:|.|:...:::||||||:.||||.......:.....:..| |..|..
  Fly   287 GLIFRSFLYLFQLIKNRKDVNYVLKASFMEIYNERVIDLLNPGSARKPLAVRWSKKSG-GFFVEN 350

  Fly   174 LTTQPVVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGIC-- 236
            |.|......:.....|..|.:||...:..||.:|||||||.|:.:     |:...:|  ||:.
  Fly   351 LFTVDCEELDDLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHI-----LSDQQTD--GGVFLS 408

  Fly   237 -RGKLSLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAK--HVPFRDSKLTR 298
             .||::.|||||||..:||.::|..|:||:.||.||..||..||||.|.|.:  |:|:|||:||:
  Fly   409 KHGKINFVDLAGSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGHIPYRDSQLTK 473

  Fly   299 LLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILY 363
            ||.|||.||..||||:|:||...::.||::|||||||||.|..||.|..||::|.       ||.
  Fly   474 LLADSLAGNGVTLMIACVSPAHYNHAETLNTLRYASRAKRIRTKPVIKMDPREAL-------ILS 531

  Fly   364 LKRMLQESQQIINKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNF 428
            |||.:...|.    .||                              :.||:...::.  ..||.
  Fly   532 LKRDIHALQM----END------------------------------HLKAALNLHHQ--AAPNG 560

  Fly   429 PLIQSKEEVQLQARS--------RIDLIKRSLIGGERIHDFELKEKHMARKYAAQRHLSAIAIAL 485
            ..:::..|:||...|        ::||.:...:.|..:  .||.:.:|.
  Fly   561 GPVENLLELQLDRVSSGGGVPVPKVDLQRLPELDGSEL--AELVKLYMV---------------- 607

  Fly   486 SRVKCEDRDLLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLN 532
                 |:..|.|.:....|....|..|....|:|..::|: ::.|:|
  Fly   608 -----ENESLRQENNHLFTVRETILRDQEIVCRENERLLK-KLEDVN 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	142/364 (39%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	137/357 (38%)
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	145/369 (39%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	140/361 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437699
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4280
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840