DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif3C and Klp98A

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_524532.2	Gene:	Klp98A / 43310	FlyBaseID:	FBgn0004387	Length:	1265	Species:	Drosophila melanogaster

Alignment Length:	818	Identity:	228/818 - (27%)
Similarity:	351/818 - (42%)	Gaps:	231/818 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNP------SARISQQKKFIFDSVY------- 55
            ::||.||.||.|..|.:.:.|.|:|:......:..|      .|.......|.||..|
  Fly     3 SLKVAVRVRPFNSREIDMDAQLIMEMENKKTRLLKPRLQSIRDAGRDNHHDFTFDYSYWSFDAED 67

  Fly    56 -NMKTDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIF 119
             :..|. |.:|.::...:|:...||||..:|||||||.|||.||.|.   .|:.|:||:..:.:|
  Fly    68 PHFATQ-EQVYSDLGNDVVDCAYEGYNACVFAYGQTGSGKTFTMMGT---PNNPGLIPRICEELF 128

  Fly   120 E--RISMTTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNA 182
            .  |:...:...|....:||||||||::|||......:.:.  ::|...:|..|..|:...|.:.
  Fly   129 ARMRVGQESGTGYRTHASYLEIYNERVKDLLAAQSTGHGLR--VREHRSLGPYVENLSQHAVSDF 191

  Fly   183 NQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAG 247
            ::..:.:..||..|.||:|.||..|||||.|||||..|:.|:|.:.|:..     .|:.||||||
  Fly   192 DEIQECIARGNAQRTTASTNMNDTSSRSHAIFTITFVQAVFMNDMPSETV-----SKIHLVDLAG 251

  Fly   248 SERQRKTGAQGDRLKEASQINLSLSALGNVISSLVD------------------GKAK---HVPF 291
            |||...|||.|.||||.:.||.||..||:|||:|.:                  |.:|   ::|:
  Fly   252 SERANATGATGQRLKEGAHINKSLVTLGSVISALAEQTGGGHNSSSSALATTPNGASKRVLYIPY 316

  Fly   292 RDSKLTRLLQDSLGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQ 356
            |||.||.||:||||||:||:||:.:||.|.:|.||:||||||:|||||.|||.:|||.....:|:
  Fly   317 RDSILTWLLKDSLGGNSKTIMIAALSPADCNYSETLSTLRYANRAKNIINKPTVNEDTNVKLIRE 381

  Fly   357 YQNEILYLKRM-------LQESQQI---INKNNDPNKII------------------------KS 387
            .:.||..||.|       ||.|.::   :.|.....|::                        ||
  Fly   382 LREEINKLKSMLAGDIHSLQPSLKVLADLQKKEAQEKVLTEEWTEKWKVAQSILQEQKSLGLRKS 446

  Fly   388 PLKIIQHTNM--------NSTKNVQIIDL--------------------------GRNCKASFKT 418
            .:.::..:.|        :.|..|.:..|                          .::|....|
  Fly   447 GVGVVLDSEMPHLIGIHNDVTTGVTLYSLKEGETRIGSEDADVAQDIELAGDGIRAQHCSIFLK- 510

  Fly   419 NNSILTKPNFPLIQ--------------------------------SKEEVQLQ---ARSRIDLI 448
             ..::|...:||.|                                ..|..:|:   :||::|:.
  Fly   511 -GGVVTLHPWPLAQCWVNAHLIDEPKQISQGDIILLGRTNIFRFNNPAEAAKLRKDLSRSQLDMS 574

  Fly   449 KRSLIGGERIH----------DFELKEKHMARKYAAQRHLS---------------AIAIALSRV 488
            :.|||...:.:          |.....|...|:|..||.:|               .|..||.::
  Fly   575 RLSLITSSKENLLTCSIYSDEDGASPYKRPERQYYPQRPMSRDDPELQDENRKILDTIENALKQL 639

  Fly   489 KCEDRDLLQGHYAT----ITQEI------DIKNDYIRKCKEK--IKMLEMEVSDLNSE------- 534
            ..| |..:...|.|    :|:|:      ::....:..|:|:  |...:|.:.:.|:|
  Fly   640 NVE-RVQMHDQYKTKVRKLTEELIRLEQEEMDGLQLLNCREQELIARKDMLLWEKNNEKVQIDIV 703

  Fly   535 --------FQLD--REDY-------LDEIRNLGR----------QVKFHQQLFLKFSSNPGKFDR 572
                    .|||  :.|:       |.|:::.|:          ....:.:|.|:.|.:...|..
  Fly   704 CRQISAFQTQLDSKKRDFSEYVAKELQELQDCGKLDEMGMKIEEGTPLNDELLLQVSDSLDLFAA 768

  Fly   573 NWTPDTILQNSLWNDDLKMW--RIPESDLIKLPPATQK 608
            .:..||:.:|   |::::..  :|.|.:.| |..:|.|
  Fly   769 QFIKDTVRRN---NEEIRKLDEQIAEKERI-LNASTTK 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	146/371 (39%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	143/365 (39%)
Klp98A	NP_524532.2	KISc_KIF1A_KIF1B	2..371	CDD:276816	151/378 (40%)
		KISc	3..371	CDD:214526	151/378 (40%)
		Kinesin_assoc	370..478	CDD:292801	20/107 (19%)
		FHA	456..555	CDD:238017	10/100 (10%)
		PX_KIF16B_SNX23	1131..1259	CDD:132784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24620at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950