Protein Alignment Kif3C and kif4

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_957117.1
• Gene: kif4 / 393796
• ZFINID: ZDB-GENE-040426-1545
• Length: 1248
• Species: Danio rerio
• Alignment Length: 696
• Identity: 214/696 - (30%)
• Similarity: 336/696 - (48%)
• Gaps: 135/696 - (19%)

  Fly     5 IKVVVRCRPMNQTEKERNCQ---NIVEINEFAVSVTNPSARISQQKKFIFDSVYNMKTDTEVIYD 66
            ::|.:||||:...|....||   |.|.        :.|...:...|.|.||.|::..|:.|.:::
Zfish    11 VRVALRCRPLVPKEINEGCQCCLNFVP--------SEPQVIVGNDKAFTFDYVFDPTTEQEEVFN 67

  Fly    67 EMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQG----DENFSNSTGIIPKCFDHIFERISMTTN 127
            .....|:....:||:.|:.||||||.|||.:|.|    ::....:.|:||:....||:..:..|:
Zfish    68 TAVSPLLSGLFKGYHATVLAYGQTGSGKTFSMGGTYTSEQENEPTVGVIPRVIRRIFQEKAKRTD 132

  Fly   128 VRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDWLHFG 192
            ..::..|:|||||||.|.|||..:::..||:  ::|.|..|:.:..||.:.|:||::....|..|
Zfish   133 CEFVLAVSYLEIYNEEILDLLCTSKDKPVIS--IREDPKDGIKIVGLTERDVLNAHEMVCCLEMG 195

  Fly   193 NKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKLSLVDLAGSERQRKTGAQ 257
            |..|...:|.||..|||||.||||:|||.  .|...:|    :...||.||||||||||:||.|:
Zfish   196 NSARTVGSTAMNAASSRSHAIFTISLEQR--RNGDKTD----VMVSKLHLVDLAGSERQKKTKAE 254

  Fly   258 GDRLKEASQINLSLSALGNVISSLVD--GKAKHVPFRDSKLTRLLQDSLGGNTKTLMISCISPTD 320
            ||||||...||..|.:||||||:|.|  .|...||:||||||||||||||||:.||||:|:||.|
Zfish   255 GDRLKEGISINRGLLSLGNVISALGDESKKGSFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPAD 319

  Fly   321 IHYDETISTLRYASRAKNISNKPKINEDPKDARLRQYQNEILYLKRML-------------QESQ 372
            .:.:|||:|||||.||:.|.|||.:|.||:.|.:::.:.::..|:.||             .|..
Zfish   320 SNIEETINTLRYADRARKIKNKPVLNVDPRAAEMKRLKQQVQELQVMLLHARGGVAPVLSGSEPA 384

  Fly   373 QIINKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKPNFPLIQSK-EE 436
            :.::|..:.|:.::         :.||..:.::.:......|.|:  ..::.:.....:||| :|
Zfish   385 ENVSKVLEQNRSLQ---------DQNSKLSRELSESVGQTAAMFE--RMLMMEQTNEKLQSKLDE 438

  Fly   437 VQLQARSRIDLIKRSLIGGERIHDFELKEK------------HMARKYA---------------- 473
            ::..|..::||  :.|:  |.:.|.||:|.            .:.|:.|
Zfish   439 LRQHAACKVDL--QRLV--ETLEDQELRENVEVIQNLQQIILELQRESAGIAATIDAITSGNASS 499

  Fly   474 --AQRHLSAIAIALSRVKCEDRD------------------LLQGHYA----TITQEIDIKNDYI 514
              |..|.|..........|..:|                  |.|...:    .:.:.:.:|..::
Zfish   500 LEAAAHCSPSTAGAQAEICPGQDGAVPEAKDSPEAYTAQHALRQAQMSKELIELNKVLALKEAFV 564

  Fly   515 RK-C-------------KEKIKMLEMEVSDLNSEFQLDREDYLDEIRNLGR---QVKFHQQLFLK 562
            :| |             :|.|:.|:..|..|    |.::||.:..:::..:   |.|..:|...:
Zfish   565 KKMCQNDSHLEPMQTQYQESIQSLQAAVGSL----QKEKEDLVQTLQSAKKDTNQAKLSEQRRKR 625

  Fly   563 FSSNPGKFDRNWTPDTILQNSLWNDDLKMWRIPESDLIKLPPATQK 608
            .....|:.       |.|:..| .|..|:.::.||.:..:....|:
Zfish   626 LQELEGQM-------TELKKKL-QDQSKLLKLKESSVRNVAKLNQE 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	151/342 (44%)
kif4	NP_957117.1	KISc_KIF4	9..339	CDD:276823	151/343 (44%)
		SMC_prok_B	<420..794	CDD:274008	45/262 (17%)
		SMC_prok_B	<621..998	CDD:274008	10/51 (20%)
		DUF3435	<938..1082	CDD:371796