DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif3C and kif18a

DIOPT Version :9

Sequence 1:	NP_651939.4	Gene:	Kif3C / 43820	FlyBaseID:	FBgn0039925	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_956533.1	Gene:	kif18a / 393209	ZFINID:	ZDB-GENE-040426-862	Length:	895	Species:	Danio rerio

Alignment Length:	683	Identity:	208/683 - (30%)
Similarity:	325/683 - (47%)	Gaps:	121/683 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NIKVVVRCRPMNQTEKERNCQNIVEINEFAVSVTNPS------------------ARISQQKKFI 50
            ::|||||.||:|..||:.|.:.:|.:.:..:.|.:|.                  .|.::..||:
Zfish     9 HVKVVVRVRPLNDKEKDGNFKKVVHVVDNHMLVFDPKEEEVTFFRGQRVGNRDVRKRANKDLKFV 73

  Fly    51 FDSVYNMKTDTEVIYDEMCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCF 115
            ||||:..::....:::....::|:..:.|||.|:||||.||.||||||.|.   |||.|::....
Zfish    74 FDSVFGEESSQIEVFENTTKAIVDGVLNGYNCTVFAYGATGAGKTHTMLGT---SNSPGVMFLTM 135

  Fly   116 DHIFERISM-----TTNVRYLALVTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLT 175
            ..:|.|:.:     ..||.:    :|||:|||:|||||     ||.....::|....||.|..||
Zfish   136 KELFARMDLIKEDKVFNVAF----SYLEVYNEQIRDLL-----TNSGPLAVREDGSNGVVVQGLT 191

  Fly   176 TQPVVNANQCYDWLHFGNKNRVTAATLMNKNSSRSHTIFTITLEQSPFLNSIGSDAFGGICRGKL 240
            .....:|....:.|.:||:||....|.||..|||||.:|.|.|.|.....|:..:    :...|:
Zfish   192 LHQPKSAEHILEALDYGNRNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASLNPN----VRVAKM 252

  Fly   241 SLVDLAGSERQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAK--HVPFRDSKLTRLLQDS 303
            ||:|||||||...|..:|.||:|.:.||.||.||||||::|.:.|.|  |:|:|||||||||:||
Zfish   253 SLIDLAGSERASATNTKGARLREGANINRSLLALGNVINTLANPKCKKTHIPYRDSKLTRLLKDS 317

  Fly   304 LGGNTKTLMISCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARLRQY-------QNEI 361
            ||||.:|:||:.:||:.:.|::|.:||:||:|||.|.:..:.|....|:.:.||       :.||
Zfish   318 LGGNCRTVMIANVSPSSLSYEDTHNTLKYANRAKEIKSTLRSNVMSLDSHIGQYAIICEKQKAEI 382

  Fly   362 LYLKRMLQESQQIINKNNDPNKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKP 426
            :.||:.|:|.::  .|...|   ..:|:.|        .|..:...:..:.::.| ::...|.|.
Zfish   383 VMLKQKLKEYEE--RKAEAP---ALNPISI--------QKRAEFEKMSESLRSVF-SDRLKLRKE 433

  Fly   427 NFPLIQSKEEVQLQARSRIDLIKRSLI-----GGERIHDFELK-EKHMARKYAAQRHLSAIAIAL 485
            :..:.:...|.:|..|.|....::|||     ..||.   ..| |:.:|...:.|.||.  ...:
Zfish   434 HLDIEKQLNESRLTMRHRESWHQQSLIFFPDNKAERA---TCKYERKLASLKSHQEHLQ--QRLM 493

  Fly   486 SRVKC-----------EDRDLLQGHYATITQEIDIKNDYIRKCKEKIKMLEMEVSDLNSEFQLDR 539
            ...||           |:...|.||.....:|:        |.:.:...|::::|||....
Zfish   494 ESEKCFQENEGWLHRIENEMKLLGHDGHTPEEL--------KKELQCHQLQLQISDLQQHM---- 546

  Fly   540 EDYLDEIRNLGRQVKFH--------------QQLFLKFSSNPGKFDRNWTPDTILQNSLWNDDLK 590
             :::..:.::..|...|              |.|.||..|..|. ...|..   |:..:..:...
Zfish   547 -EHMSHLISVQDQENTHTHKLVNALLSTCRRQHLALKAMSADGD-GSEWEE---LERLVHRERAV 606

  Fly   591 MWRIPESDLIKLPPATQKSGLHCIH--PLVIHS 621
            :|    :|..|.......||:...|  |::..|
Zfish   607 VW----ADQEKAEDKRDDSGIGSTHLRPILSFS 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:277568	144/359 (40%)
Kif3C	NP_651939.4	Kinesin	10..339	CDD:278646	140/353 (40%)
kif18a	NP_956533.1	KISc	9..354	CDD:214526	144/360 (40%)
kif18a	NP_956533.1	KISc_KIP3_like	9..353	CDD:276821	144/359 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910