Protein Alignment Kif3C and KIF22

DIOPT Version :10

• Sequence 1: NP_651939.4
• Gene: Kif3C / 43820
• FlyBaseID: FBgn0039925
• Length: 649
• Species: Drosophila melanogaster
• Sequence 2: NP_015556.1
• Gene: KIF22 / 3835
• HGNCID: 6391
• Length: 665
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 182/619 - (29%)
• Similarity: 294/619 - (47%)
• Gaps: 83/619 - (13%)

  Fly     5 IKVVVRCRP-MNQTEKERNCQNIVEINEFAVSVTNPSARISQQK-KFIFDSVYNMKTDTEVIYDE 67
            ::|.||.|| ::.|....:...:..::..::.:.|  .|..|:. |:.||:.|..::..:.||..
Human    44 VRVAVRLRPFVDGTAGASDPPCVRGMDSCSLEIAN--WRNHQETLKYQFDAFYGERSTQQDIYAG 106

  Fly    68 MCYSLVESTIEGYNGTIFAYGQTGCGKTHTMQGDENFSNSTGIIPKCFDHIFERISMT----TNV 128
            ....::...:||.|.::.|||.||.||||||.|.   ....|:||:.   :.:.:.:|    ...
Human   107 SVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGS---PEQPGVIPRA---LMDLLQLTREEGAEG 165

  Fly   129 RYLAL---VTYLEIYNERIRDLLNKNENTNVINHFLKELPGIGVSVPTLTTQPVVNANQCYDW-L 189
            |..||   ::|||||.|::.|||:......||.   ::..| .:.:|.|:.:|:   :...|: .
Human   166 RPWALSVTMSYLEIYQEKVLDLLDPASGDLVIR---EDCRG-NILIPGLSQKPI---SSFADFER 223

  Fly   190 HF--GNKNRVTAATLMNKNSSRSHTIFTITLEQ----SPFLNSIGSDAFGGICRGKLSLVDLAGS 248
            ||  .::||...||.:|:.|||||.:..:.::|    :||...          .|||.|:|||||
Human   224 HFLPASRNRTVGATRLNQRSSRSHAVLLVKVDQRERLAPFRQR----------EGKLYLIDLAGS 278

  Fly   249 ERQRKTGAQGDRLKEASQINLSLSALGNVISSLVDGKAKHVPFRDSKLTRLLQDSLGGNTKTLMI 313
            |..|:||.:|.||||:..||.||..||.|:.:|..|..: ||:|||||||||||||||:..:::|
Human   279 EDNRRTGNKGLRLKESGAINTSLFVLGKVVDALNQGLPR-VPYRDSKLTRLLQDSLGGSAHSILI 342

  Fly   314 SCISPTDIHYDETISTLRYASRAKNISNKPKINEDPKDARL---RQYQNEIL---YLKRMLQESQ 372
            :.|:|....|.:|:|.|.:|:|:|.:.|:|..||..:...|   :..|.|:|   ..||.....:
Human   343 ANIAPERRFYLDTVSALNFAARSKEVINRPFTNESLQPHALGPVKLSQKELLGPPEAKRARGPEE 407

  Fly   373 QIINKNNDP--------NKIIKSPLKIIQHTNMNSTKNVQIIDLGRNCKASFKTNNSILTKP--- 426
            :.|. :.:|        .|:  |||:.:  ::|:.....:::.|.|...:.......:|:.|
Human   408 EEIG-SPEPMAAPASASQKL--SPLQKL--SSMDPAMLERLLSLDRLLASQGSQGAPLLSTPKRE 467

  Fly   427 NFPLIQSKEEVQLQARSRIDLIKRSLIGGERIHDFELKEKHMARKYAAQRHLSAI-AIALSRVKC 490
            ...|:::.||..|:. .|:...::.|.........|.||.|.........|.:.. |..|.:...
Human   468 RMVLMKTVEEKDLEI-ERLKTKQKELEAKMLAQKAEEKENHCPTMLRPLSHRTVTGAKPLKKAVV 531

  Fly   491 EDRDLLQGHYATITQEIDIKNDYIRKCK-EKIKMLEMEVSDLNS-EFQLDRE----------DYL 543
            ....|:|...|:...||.|..:..||.| |.:..||.|....:. |.|:..|          |.|
Human   532 MPLQLIQEQAASPNAEIHILKNKGRKRKLESLDALEPEEKAEDCWELQISPELLAHGRQKILDLL 596

  Fly   544 DE-----IRNLGRQVKFHQQLFLKFSSNPGKFDR 572
            :|     :|:|.|......||.:.:....|.|.:
Human   597 NEGSARDLRSLQRIGPKKAQLIVGWRELHGPFSQ 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif3C	NP_651939.4	Motor_domain	3..339	CDD:473979	122/349 (35%)
KIF22	NP_015556.1	KISc_KID_like	43..366	CDD:276827	121/347 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..428		9/51 (18%)
		ComEA	596..646	CDD:441164	9/35 (26%)